Impaired humoral and cellular response to primary COVID ‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant

Autor: Sam M. Murray, Maria Barbanti, Cori Campbell, Anthony Brown, Lucia Chen, Jay Dhanapal, Bing Tseu, Omer Pervaiz, Louis Peters, Sally Springett, Robert Danby, Sandra Adele, Eloise Phillips, Tom Malone, Ali Amini, Lizzie Stafford, Alexandra S. Deeks, Susanna Dunachie, Paul Klenerman, Andrew Peniket, Eleanor Barnes, Murali Kesavan

Publikováno v: British Journal of Haematology. 198:668-679

Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID-19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f12ee93f1e94500856d2da8e0de2596
https://doi.org/10.1111/bjh.18312

Immune boosting by B.1.1.529

Autor: Catherine J, Reynolds, Corinna, Pade, Joseph M, Gibbons, Ashley D, Otter, Kai-Min, Lin, Diana, Muñoz Sandoval, Franziska P, Pieper, David K, Butler, Siyi, Liu, George, Joy, Nasim, Forooghi, Thomas A, Treibel, Charlotte, Manisty, James C, Moon, Amanda, Semper, Tim, Brooks, Áine, McKnight, Daniel M, Altmann, Rosemary J, Boyton, Hakam, Abbass, Aderonke, Abiodun, Mashael, Alfarih, Zoe, Alldis, Oliver E, Amin, Mervyn, Andiapen, Jessica, Artico, João B, Augusto, Georgina L, Baca, Sasha N L, Bailey, Anish N, Bhuva, Alex, Boulter, Ruth, Bowles, Olivia V, Bracken, Ben, O'Brien, Natalie, Bullock, Gabriella, Captur, Olivia, Carr, Nicola, Champion, Carmen, Chan, Aneesh, Chandran, Tom, Coleman, Jorge, Couto de Sousa, Xose, Couto-Parada, Eleanor, Cross, Teresa, Cutino-Moguel, Silvia, D'Arcangelo, Rhodri H, Davies, Brooke, Douglas, Cecilia, Di Genova, Keenan, Dieobi-Anene, Mariana O, Diniz, Anaya, Ellis, Karen, Feehan, Malcolm, Finlay, Marianna, Fontana, Sasha, Francis, David, Gillespie, Derek, Gilroy, Matt, Hamblin, Gabrielle, Harker, Georgia, Hemingway, Jacqueline, Hewson, Wendy, Heywood, Lauren M, Hickling, Bethany, Hicks, Aroon D, Hingorani, Lee, Howes, Ivie, Itua, Victor, Jardim, Wing-Yiu Jason, Lee, Melaniepetra, Jensen, Jessica, Jones, Meleri, Jones, Vikas, Kapil, Caoimhe, Kelly, Hibba, Kurdi, Jonathan, Lambourne, Aaron, Lloyd, Sarah, Louth, Mala K, Maini, Vineela, Mandadapu, Katia, Menacho, Celina, Mfuko, Kevin, Mills, Sebastian, Millward, Oliver, Mitchelmore, Christopher, Moon, James, Moon, Sam M, Murray, Mahdad, Noursadeghi, Ashley, Otter, Susana, Palma, Ruth, Parker, Kush, Patel, Mihaela, Pawarova, Steffen E, Petersen, Brian, Piniera, Lisa, Rannigan, Alicja, Rapala, Amy, Richards, Matthew, Robathan, Joshua, Rosenheim, Cathy, Rowe, Matthew, Royds, Jane, Sackville West, Genine, Sambile, Nathalie M, Schmidt, Hannah, Selman, Andreas, Seraphim, Mihaela, Simion, Angelique, Smit, Michelle, Sugimoto, Leo, Swadling, Stephen, Taylor, Nigel, Temperton, Stephen, Thomas, George D, Thornton, Art, Tucker, Ann, Varghese, Jessry, Veerapen, Mohit, Vijayakumar, Tim, Warner, Sophie, Welch, Hannah, White, Theresa, Wodehouse, Lucinda, Wynne, Dan, Zahedi, Benjamin, Chain

Publikováno v: Science (New York, N.Y.). 377(6603)

The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e47a2d7e1518955cbeb0d526fe6ff6db
https://pubmed.ncbi.nlm.nih.gov/35699621

Chlamydia trachomatis: Cell biology, immunology and vaccination

Autor: Paul F. McKay, Sam M. Murray

Publikováno v: Vaccine. 39:2965-2975

Chlamydia trachomatis is the causative agent of a highly prevalent sexually transmitted bacterial disease and is associated with a number of severe disease complications. Current therapy options are successful at treating disease, but patients are le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72a91ee6fbc05a96a0ea5423d9f1c8c
https://doi.org/10.1016/j.vaccine.2021.03.043

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

Autor: Rishi K Gupta, Joshua Rosenheim, Lucy C Bell, Aneesh Chandran, Jose A Guerra-Assuncao, Gabriele Pollara, Matthew Whelan, Jessica Artico, George Joy, Hibba Kurdi, Daniel M Altmann, Rosemary J Boyton, Mala K Maini, Aine McKnight, Jonathan Lambourne, Teresa Cutino-Moguel, Charlotte Manisty, Thomas A Treibel, James C Moon, Benjamin M Chain, Mahdad Noursadeghi, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Oliver E Amin, Mervyn Andiapen, João B Augusto, Georgiana L Baca, Sasha NL Bailey, Anish N Bhuva, Alex Boulter, Ruth Bowles, Olivia V Bracken, Ben O'Brien, Tim Brooks, Natalie Bullock, David K Butler, Gabriella Captur, Nicola Champion, Carmen Chan, David Collier, Jorge Couto de Sousa, Xose Couto-Parada, Rhodri H Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Marianna Fontana, Nasim Forooghi, Celia Gaier, Joseph M Gibbons, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Jacqueline Hewson, Lauren M Hickling, Aroon D Hingorani, Lee Howes, Alun Hughes, Gemma Hughes, Rebecca Hughes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, Vikas Kapil, Kai-Min Lin, Sarah Louth, Vineela Mandadapu, Áine McKnight, Katia Menacho, Celina Mfuko, Oliver Mitchelmore, Christopher Moon, Diana Munoz Sandoval, Sam M Murray, Ashley Otter, Corinna Pade, Susana Palma, Ruth Parker, Kush Patel, Babita Pawarova, Steffen E Petersen, Brian Piniera, Franziska P Pieper, Daniel Pope, Maria Prossora, Lisa Rannigan, Alicja Rapala, Catherine J Reynolds, Amy Richards, Matthew Robathan, Genine Sambile, Nathalie M Schmidt, Amanda Semper, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D Thornton, Art Tucker, Jessry Veerapen, Mohit Vijayakumar, Sophie Welch, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi

Publikováno v: The Lancet. Microbe
e517
e508

Summary Background We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde402339b8e0a6b0a82a86880bd34b3
http://europepmc.org/articles/PMC8260104

Examining the Immunological Effects of COVID-19 Vaccination in Patients with Conditions Potentially Leading to Diminished Immune Response Capacity – The OCTAVE Trial

Autor: Thomas Marjot, Pamela Kearns, Ana Hughes, Thushan I de Silva, Michelle Willicombe, Sarah Pirrie, Amanda Kirkham, Georgina Meacham, Daniel Rea, Stefan Siebert, Sophie L. Irwin, Susanna Dunachie, Lance Turtle, Sophia Magwaro, Zixiang Lim, Carl S. Goodyear, David B. Thomas, Stavros I. Dimitriadis, Alex G. Richter, Jack Satsangi, Charlotte Gaskell, Iain B. McInnes, Peter Kelleher, Paul B. Miller, Eleanor Barnes, Sarah Bowden, Zay Win, Neil Basu, Paul Klenerman, Gordon Cook, Sam M. Murray

Publikováno v: SSRN Electronic Journal.

SARS-COV-2 vaccines have been shown to be efficacious primarily in healthy volunteer populations and population level studies. Immune responses following SARS-CoV-2 vaccination are less well characterised in potentially immune vulnerable patient grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96cf0c656b906ea56f071e816959d6c3
https://doi.org/10.2139/ssrn.3910058