Výsledky vyhledávání

Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes

Autor: Francesco Caiazza, Patricia C. Conroy, Sam L. Ivry, Tyler York, Joseph Lin, Sophia Hernandez, Thomas J. Hoffmann, Stephen S. Francis, Walter G. Park, Michele T. Yip-Schneider, C. Max Schmidt, Randall Brand, Charles S. Craik, Kimberly Kirkwood

Publikováno v: Journal of Surgical Research. 284:322-331

The accurate identification of mucinous pancreatic cystic lesions (PCLs) is paramount for cancer risk stratification. Cyst fluid carcinoembryonic antigen (CEA), the only routinely used test, requires high volumes and has low sensitivity. We aimed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ceb81cbae00ce43b1f659e2248f3f22
https://doi.org/10.1016/j.jss.2022.08.014

Zobrazit plný text záznamu

Data from Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts

Autor: Charles S. Craik, Kimberly S. Kirkwood, Anthony J. O'Donoghue, Grace E. Kim, Matthias Hebrok, Walter G. Park, Randall E. Brand, C. Max Schmidt, Michele T. Yip-Schneider, Stacy E. Hatcher, Nilotpal Roy, Dana A. Dominguez, Jeremy M. Sharib, Sam L. Ivry

Purpose: Pancreatic cysts are estimated to be present in 2%–3% of the adult population. Unfortunately, current diagnostics do not accurately distinguish benign cysts from those that can progress into invasive cancer. Misregulated pericellular prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375271721bb6a523d03b423425b9b284
https://doi.org/10.1158/1078-0432.c.6525474

Zobrazit plný text záznamu

Akademický článek

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.

Autor: Louise S Goupil, Sam L Ivry, Ivy Hsieh, Brian M Suzuki, Charles S Craik, Anthony J O'Donoghue, James H McKerrow

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004893 (2016)

Proteases perform numerous vital functions in flatworms, many of which are likely to be conserved throughout the phylum Platyhelminthes. Within this phylum are several parasitic worms that are often poorly characterized due to their complex life-cycl

Externí odkaz: https://doaj.org/article/40ef71f4033643a6bc3c7941a770802a

Zobrazit plný text záznamu

Abstract 2226: Using functional biomarkers to accurately predict advanced neoplasia in pancreatic cystic lesions

Autor: Francesco Caiazza, Andre Lourenco, Patricia Conroy, Thomas Hoffmann, Sam L. Ivry, Tyler York, Gina Zhu, Audrey Mustoe, Anthony J. O'Donoghue, Charles S. Craik, Kimberly Kirkwood

Publikováno v: Cancer Research. 82:2226-2226

Background: The accurate identification of high-grade dysplasia (HGD) or invasive cancer (advanced neoplasia, AN) in pancreatic cystic lesions (PCLs) is needed to identify PCLs that warrant surgical intervention. Cytologic evaluation of cyst fluid is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56ef57691c363772c1635e2239c4e129
https://doi.org/10.1158/1538-7445.am2022-2226

Zobrazit plný text záznamu

Global substrate specificity profiling of post-translational modifying enzymes

Autor: Markus-Frederik Bohn, Michael B. Winter, Nicole O. Meyer, Sam L. Ivry, Charles S. Craik, Giselle M. Knudsen, Anthony J. O’Donoghue

Publikováno v: Protein Science. 27:584-594

Enzymes that modify the proteome, referred to as post-translational modifying (PTM) enzymes, are central regulators of cellular signaling. Determining the substrate specificity of PTM enzymes is a critical step in unraveling their biological function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c773448f40cb660c5c560e27271d080
https://doi.org/10.1002/pro.3352

Zobrazit plný text záznamu

The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts

Autor: Kimberly S. Kirkwood, Sam L. Ivry, Charles S. Craik, Francesco Caiazza, Matthew Ravalin, Jeremy Sharib, Anthony J. O’Donoghue, Giselle M. Knudsen, Katrin Jaradeh

Publikováno v: Biological chemistryReferences. 400(12)

Incidental detection of pancreatic cysts has increased dramatically over the last decade, but risk stratification and clinical management remain a challenge. Mucinous cysts are precursor lesions to pancreatic cancer, however, the majority are indolen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ba1cc7d6798bbb128e6a4d7d47896e
https://pubmed.ncbi.nlm.nih.gov/31256057

Zobrazit plný text záznamu

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

Autor: Wilian A. Cortopassi, Andrea R. Argouarch, Aimee W. Kao, Matthew P. Jacobson, Victoria J. Butler, Charles S. Craik, Sam L. Ivry

Publikováno v: Journal of molecular biology, vol 431, iss 5

Single-copy loss-of-function mutations in the progranulin gene (PGRN) underlie the neurodegenerative disease frontotemporal lobar degeneration, while homozygous loss-of-function of PGRN results in the lysosomal storage disorder neuronal ceroid lipofu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865fc5afe46dcea2e3db395b8c36d755
https://pubmed.ncbi.nlm.nih.gov/30690031

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání