What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

Autor: Babette Verkouteren, Dan Piña-Fuentes, Martijn Beudel, Thomas Ludden, Rik H G Olde Engberink, Tom Dormans, Martijn D de Kruif, Suat Simsek, Joop P van den Bergh, Hazra Moeniralam, Renee Douma, Kees Brinkman, Wouter Hinsenveld, Lucas Ramos, Anne Pirson, Deborah Hubers, Shi Hu, Rajat Thomas, Michiel Schinkel, Caroline E Wyers, Daisy Rusch, Lianne de Haan, Niels C Gritters van den Oever, Nienke Paternotte, Robert-Jan Goldhoorn, Brent Appelman, Esther Lems, Marije ten Wolde, Esther K Haspels-Hogervorst, Neyma Bokhizzou, Niels Gritters van den Oever, Joop van den Bergh, Martijn de Kruif, Helen Leavis, Derk Arts, Nick Nurmohamed, Rens Reeskamp, Willem Herter, Bas Vonk, Ricardo Lopes, Deborah Huberts, Marije Wolfers, Sander de Kuij, Sophie Noordzij, Sibbeliene van den Bosch, Benthe Verhoef, Michele Methorst, Shahan Darwesh, Tijn van Egmond, Gulsum Nasim, Hamza Ali, Lars de Boer, Myrthe Nagel, Maud Koenis, Agnetha Bijlsma, Britt Balvers, Isabella Ghauharali, Jelle de Jongh, Maira Emanuel, Nisrine Aynaou, Rosemarie de Ridder, Insaff Darraz, Oumaima Darraz, Alanar Cinar, Jesse Roosen, Larissa Heideman, Asabi Leliveld, Dana Ruijter, Neeltje Rosenberg, Djoeke Woutman, Tom Vermeulen, Sam de Joode, Willem Berger, Ozgu Varan, Soesja Pinto, Sientje Sluis, Bibi Kuiper, Tim van der Putten, Dominique Bosje, Mahunda Sinyangwe, Roos van Rhijn, Koen Kruif, Miriam den Heijer, Koen de Kruijf, Sam Hofhuis, Gwendolyn Telting, Susan van der Lei, Pien van Paassen, Emil ter Veer, Krijna Opschoor, Camille Breukhoven, Florine Jiwa, Peter de Gooyer, Jan Vrijdag, Stans van Gelder, Anne Pannekoek, Laura Dommershuijzen, Estelle Adang, Maud van Maren, Isabel Koop, Bart Sanders, Joukje Wanten, Dax Trommelen, Fleur Smeets, Kyra Heuvelings, Maud Cox, Milou Rademaekers, Vivian Hendrikx, Ilona van Rooij, Wendy Heuts, Laura Oudeman, Evelien Brans, Karin Slot, Kirsten Boerma-Argelo, Wilma Kok, Lieke Harmsen, Ingrid Boerema, Anne Raafs, Anne Smaal, Bibiane Pop, Carmen Waterink, Casper Vrij, Daphne van der Willik, Frederic Reitsma, Imogene Pieters, Jade Logger, Laura Sijben, Maikel Peeters, Mariël Teunissen, Marije Blok-Hoos, Marjolein Ketels, Michiel Henkens, Mireille Spanjers, Monique Jacob-Dols, Patrick de Hoogt, Rik Houben, Roos van Gorp, Josien Jansen

Publikováno v: BMJ Open, Vol 13, Iss 11 (2023)

Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatrae

Externí odkaz: https://doaj.org/article/fad6410fff844b2180af17e45d668c56

Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies

Autor: Aafke Aartse, Daniella Mortier, Petra Mooij, Sam Hofman, Marlies M. van Haaren, Martin Corcoran, Gunilla B. Karlsson Hedestam, Dirk Eggink, Mathieu Claireaux, Willy M. J. M. Bogers, Marit J. van Gils, Gerrit Koopman

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Several studies have shown that the first encounter with influenza virus shapes the immune response to future infections or vaccinations. However, a detailed analysis of the primary antibody response is lacking as this is difficult to study in humans

Externí odkaz: https://doaj.org/article/ed98b50c9d954d01b3e2bfe78460e7bc