Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sam Heywood"'
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182695 (2017)
A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral
Externí odkaz:
https://doaj.org/article/b1a1afe744bf41db8e0244f86d7fdb09
Autor:
Jean M. H. van den Elsen, Bruce Carrington, Neesha Dedi, Xiaofeng Liu, Alastair D. G. Lawson, Sam Heywood, Jeffery Kennedy, Alex Macpherson, Oliver Durrant
Publikováno v:
The Journal of Biological Chemistry
Macpherson, A, Liu, X, Dedi, N, Kennedy, J, Carrington, B, Durrant, O, Heywood, S, van den Elsen, J & Lawson, A D G 2018, ' The rational design of affinity attenuated OmCI for the purification of Complement C5 ', The Journal of biological chemistry, vol. 293, no. 36, pp. 14112-14121 . https://doi.org/10.1074/jbc.RA118.004043
Macpherson, A, Liu, X, Dedi, N, Kennedy, J, Carrington, B, Durrant, O, Heywood, S, van den Elsen, J & Lawson, A D G 2018, ' The rational design of affinity attenuated OmCI for the purification of Complement C5 ', The Journal of biological chemistry, vol. 293, no. 36, pp. 14112-14121 . https://doi.org/10.1074/jbc.RA118.004043
Complement component C5 is the target of the monoclonal antibody Eculizumab, and the focus of a sustained drug discovery effort to prevent complement-induced inflammation in a range of autoimmune diseases. The immune evasion protein OmCI binds to, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619032f2cfe4e56c3f8d0c66217615fc
https://doi.org/10.1074/jbc.ra118.004043
https://doi.org/10.1074/jbc.ra118.004043
Publikováno v:
Dramatherapy. 26:10-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8c6ddc889613be54dc5131ac794583
https://doi.org/10.1080/02630672.2004.9689634
https://doi.org/10.1080/02630672.2004.9689634
Publikováno v:
Clinical Child Psychology and Psychiatry. 8:503-512
In England, the demand for, and access to Child and Adolescent Mental Health Services (CAMHS) have led to endemic and intractable problems: long waiting lists, non-attendance and complaints of inaccessibility from both users and referrers. The dilemm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a7d80e163d8d965cbddba9f473d54b
https://doi.org/10.1177/13591045030084007
https://doi.org/10.1177/13591045030084007
Autor:
Sam Heywood, Dee Athwal, Bruce Carrington, Andrew George Popplewell, Andrew Nesbitt, Alastair David Griffiths Lawson, Amanda J. Suitters, and Alison Eddelston, P. Antoniw, Shauna West, Bryan Smith, Andrew Paul Chapman
Publikováno v:
Bioconjugate Chemistry. 12:750-756
Antibody fragments can be expressed at a high level in microbial systems, but they may have limited therapeutic value because they are rapidly eliminated from the body. We demonstrate here that site-specific conjugation or binding of bacterially deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5434c88aa338f9e6e4a01260e01c00
https://doi.org/10.1021/bc010003g
https://doi.org/10.1021/bc010003g