Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sam Gusscott"'
Autor:
Patrizio Panelli, Elisabetta De Santis, Mattia Colucci, Francesco Tamiro, Francesca Sansico, Mattia Miroballo, Emanuele Murgo, Costanzo Padovano, Sam Gusscott, Michele Ciavarella, Elizabeth A. Chavez, Fabrizio Bianchi, Giovanni Rossi, Angelo M. Carella, Christian Steidl, Andrew P. Weng, Vincenzo Giambra
Publikováno v:
Blood. 141:1597-1609
T-cell acute lymphoblastic leukemia (T-ALL) is a T-cell malignancy characterized by cell subsets and enriched with leukemia-initiating cells (LICs). β-Catenin modulates LIC activity in T-ALL. However, its role in maintaining established leukemia ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4deabc15e6170e386b5ab6d381aa5358
https://doi.org/10.1182/blood.2022017079
https://doi.org/10.1182/blood.2022017079
Publikováno v:
Experimental Hematology. 111:S137-S138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c7bac11085719a8779595772ec23b1
https://doi.org/10.1016/j.exphem.2022.07.242
https://doi.org/10.1016/j.exphem.2022.07.242
Autor:
Sam Gusscott, Emmanouil Kyroglou, Kelly Wei, Martin Hirst, Keith Humphries, Ann Chong Sun, Manabu Kusakabe, Kateryna Tyshchenko, Tracy Huynh, Andrew P. Weng, Connie J. Eaves, Aastha Nanda, Gilmar Gutierrez
Publikováno v:
Experimental Hematology. 76:e3
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with diverse oncogenic drivers, the relative contributions of which remain obscure. Enforced expression of select oncogenes is sufficient to generate T-ALL in mice, however, mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99eecb315dfd58a9ccb1a2e4545809ad
https://doi.org/10.1016/j.exphem.2019.09.011
https://doi.org/10.1016/j.exphem.2019.09.011
Autor:
Connie J. Eaves, Hongfang Wang, Jon C. Aster, Oksana Nemirovsky, R. Keith Humphries, Andrew P. Weng, Christopher R Jenkins, Carol Wai, Sonya H Lam, Sam Gusscott, Mark Y. Chiang, Olena O Shevchuk, Vincenzo Giambra
Publikováno v:
Nature Medicine. 18:1693-1698
Reactive oxygen species (ROS), a byproduct of cellular metabolism, damage intracellular macromolecules and, when present in excess, can promote normal hematopoietic stem cell differentiation and exhaustion. However, mechanisms that regulate the amoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fda44a27f4c7f84388732e2bf0ce37e0
https://doi.org/10.1038/nm.2960
https://doi.org/10.1038/nm.2960
Autor:
Miriam Belmonte, Vincenzo Giambra, Catherine Hoofd, Xuehai Wang, Catherine E. Jenkins, Sam Gusscott, Sonya H Lam, Deanne Gracias, Andrew P. Weng
Publikováno v:
Blood. 125(25)
The Wnt signaling pathway has been shown to play important roles in normal hematopoietic stem cell biology and in the development of both acute and chronic myelogenous leukemia. Its role in maintaining established leukemia stem cells, which are more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8731b69fce262f4acc39f72a686197f9
https://pubmed.ncbi.nlm.nih.gov/25934477
https://pubmed.ncbi.nlm.nih.gov/25934477
Publikováno v:
Blood. 128:5083-5083
T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy characterized by an uncontrolled proliferation of immature T-cells. While current therapies cure ~80% of pediatric patients, adults fare more poorly with ~40% overall survival. Refractory ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989465e97959c3504ab5e09393f5d625
https://doi.org/10.1182/blood.v128.22.5083.5083
https://doi.org/10.1182/blood.v128.22.5083.5083
Autor:
Vincenzo Giambra, Sam Gusscott, Alireza Lorzadeh, Catherine Hoofd, Fong Chun Chan, Christian Steidl, Miriam Belmonte, Martin Hirst, Sohrab Salehi, Andrew P. Weng, Robert Kridel, Connie J. Eaves, Sonya H Lam
Publikováno v:
Blood. 126:3637-3637
T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of immature T-cell progenitors, characterized by activating NOTCH1 mutations in over 50% of children and adult cases. Although intensive multiagent chemotherapy achieves cure in most pediatr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d23a273a4e19853159224f97bccb7c
https://doi.org/10.1182/blood.v126.23.3637.3637
https://doi.org/10.1182/blood.v126.23.3637.3637