Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sam Aparicio"'
Autor:
Andrew W. McPherson, Andrew Roth, Gavin Ha, Cedric Chauve, Adi Steif, Camila P. E. de Souza, Peter Eirew, Alexandre Bouchard-Côté, Sam Aparicio, S. Cenk Sahinalp, Sohrab P. Shah
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sample
Externí odkaz:
https://doaj.org/article/99c30900a9c74f33a721484d36c747f6
Autor:
Andrew W. McPherson, Andrew Roth, Gavin Ha, Cedric Chauve, Adi Steif, Camila P. E. de Souza, Peter Eirew, Alexandre Bouchard-Côté, Sam Aparicio, S. Cenk Sahinalp, Sohrab P. Shah
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/42c5c823f94244ef8313eed03f91e1fa
Autor:
Anamaria Crisan, Rodrigo Goya, Gavin Ha, Jiarui Ding, Leah M Prentice, Arusha Oloumi, Janine Senz, Thomas Zeng, Kane Tse, Allen Delaney, Marco A Marra, David G Huntsman, Martin Hirst, Sam Aparicio, Sohrab Shah
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41551 (2012)
Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generati
Externí odkaz:
https://doaj.org/article/c839d4c639fe4c849330294810dba997
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Karen Van Baelen, Maxim De Schepper, Sophia Leduc, Edoardo Isnaldi, Sam Aparicio, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Andrew Green, Hazem Khout, Eyfjörð Jórunn, Stian Knappskog, Savitri Krishnamurthy, Sunil Lakhani, Anita Langerod, John WM Martens, Leigh Murphy, Serena Nik-Zainal, Colin Purdie, Emad Rakha, Andrea Richardson, Anne Salomon, Peter Simpson, Christos Sotiriou, Paul Span, Benita Kiat-Tee Tan, Alastair Thompson, Stefania Tommasi, Marc Van de Vijver, Steven Van Laere, Alain Viari, Giuseppe Floris, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Cancer Research. 82:P3-09
Background: High body mass index (BMI) is an established risk factor for developing breast cancer (BC), especially estrogen receptor (ER)-positive, and also has been associated with adverse survival. Still, patients with BC are currently treated inde
Autor:
Farhia Kabeer, Goldman Lam, Naila Adam, Maxwell Douglas, Amal El-Naggar, Forouh Kalantari, Mengke Han, Vinci Au, Michael Van Vliet, Cindy Shen, Sean Beaty, Daniel Lai, Andy Mungall, Richard Moore, Sam Aparicio, Andrew Roth, David Huntsman, Yvette Drew
Publikováno v:
Cancer Research. 83:2182-2182
Introduction: High-grade serous ovarian cancer (HGSOC) is driven by loss of TP53 and genome instability . Despite the recent success of PARP inhibitors, advanced BRCA mutant and homologous recombination repair deficient (HRD) HGSOC, chemotherapy rema
Autor:
Sam Aparicio
Publikováno v:
The Breast. 24:S30
Next generation sequencing analysis of ctDNA in plasma could also complement current invasive biopsy approaches to identify mutations associated with acquired drug resistance in advanced disease. [1] Bidard FC., et al Clinical validity of circulating
Autor:
Andrew E, Teschendorff, Ali, Naderi, Nuno L, Barbosa-Morais, Sarah E, Pinder, Ian O, Ellis, Sam, Aparicio, James D, Brenton, Carlos, Caldas
Publikováno v:
Genome Biology
A consensus prognostic classifier for estrogen receptor positive breast tumors has been developed and shown to be valid in nearly 900 samples across different microarray platforms.
Background A consensus prognostic gene expression classifier is
Background A consensus prognostic gene expression classifier is