Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sam Afkhami"'
Autor:
Nadia Milad, Matthew F. Fantauzzi, Joshua J.C. McGrath, Steven P. Cass, Danya Thayaparan, Peiyao Wang, Sam Afkhami, Jennifer A. Aguiar, Kjetil Ask, Andrew C. Doxey, Martin R. Stampfli, Jeremy A. Hirota
Publikováno v:
ERJ Open Research, Vol 9, Iss 6 (2023)
Rationale Despite its increasingly widespread use, little is known about the impact of cannabis smoking on the response to viral infections like influenza A virus (IAV). Many assume that cannabis smoking will disrupt antiviral responses in a manner s
Externí odkaz:
https://doaj.org/article/701d31614b5d4540a65bf088276e3fa6
Autor:
Sam Afkhami, Michael R. D’Agostino, Maryam Vaseghi-Shanjani, Madeleine Lepard, Jack X. Yang, Rocky Lai, Margaret Wa Yan Choi, Alexis Chacon, Anna Zganiacz, Kees L. M. C. Franken, Hildegund C. Ertl, Tom H. M. Ottenhoff, Mangalakumari Jeyanathan, Amy Gillgrass, Zhou Xing
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately, current monovalent viral-vectored tuberculosis (TB) vaccine candi
Externí odkaz:
https://doaj.org/article/d2dc7116602d419c9248036c6fe44964
Autor:
Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi‐Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 7, Pp n/a-n/a (2023)
Abstract Bacillus Calmette‐Guérin (BCG) still remains the only licensed vaccine for TB and has been shown to provide nonspecific protection against unrelated pathogens. This has been attributed to the ability of BCG to modulate the innate immune s
Externí odkaz:
https://doaj.org/article/5c2bf5230b074316873aab5bc4197134
Autor:
Vidthiya Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Anna Zganiacz, Xueya Feng, Matthew S. Miller, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c856bac2872e46baa16f773ee3d65cfd
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101652- (2022)
Summary: Vaccination route dictates the quality and localization of immune responses within tissues. Intranasal vaccination seeds tissue-resident adaptive immunity, alongside trained innate responses within the lung/airways, critical for superior pro
Externí odkaz:
https://doaj.org/article/728354982a50498b8131ad224f237196
Autor:
Vidthiya Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Anna Zganiacz, Xueya Feng, Matthew S. Miller, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Infectious diseases of the respiratory tract are one of the top causes of global morbidity and mortality with lower respiratory tract infections being the fourth leading cause of death. The respiratory mucosal (RM) route of vaccine delivery represent
Externí odkaz:
https://doaj.org/article/a7fa0557e72b4dc1b5883d697c80c810
Autor:
Mangalakumari Jeyanathan, Dominik K. Fritz, Sam Afkhami, Emilio Aguirre, Karen J. Howie, Anna Zganiacz, Anna Dvorkin-Gheva, Michael R. Thompson, Richard F. Silver, Ruth P. Cusack, Brian D. Lichty, Paul M. O’Byrne, Martin Kolb, Maria Fe C. Medina, Myrna B. Dolovich, Imran Satia, Gail M. Gauvreau, Zhou Xing, Fiona Smaill
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via i.m. injection to humans and are incapable of inducing respiratory mucosal immunity. However, aerosol delivery of Ad-vectored vaccines remains poorly characterized,
Externí odkaz:
https://doaj.org/article/0f5b7f6ff7fa419a8108b00742172faf
Autor:
Madeleine Lepard, Jack X. Yang, Sam Afkhami, Aisha Nazli, Anna Zganiacz, Shangguo Tang, Margaret Wa Yan Choi, Fatemah Vahedi, Alexandre Deshiere, Michel J. Tremblay, Zhou Xing, Charu Kaushic, Amy Gillgrass
Publikováno v:
Viruses, Vol 14, Iss 9, p 1927 (2022)
In people living with HIV, Mycobacterium tuberculosis (Mtb) is the major cause of death. Due to the increased morbidity/mortality in co-infection, further research is urgently required. A limiting factor to research in HIV and HIV/Mtb co-infection is
Externí odkaz:
https://doaj.org/article/5b98d467a3d942cca7b2d2b38ba2bc94
Autor:
Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Wael L. Demian, Kaushal Baid, Michael R. D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477- (2021)
Summary: Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production i
Externí odkaz:
https://doaj.org/article/7903286efe6640018b5c5ad804e712c6
Autor:
Sam Afkhami, Anne Drumond Villela, Michael R. D’Agostino, Mangalakumari Jeyanathan, Amy Gillgrass, Zhou Xing
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chemotherapeutic intervention remains the primary strategy in treating and controlling tuberculosis (TB). However, a complex interplay between therapeutic and patient-related factors leads to poor treatment adherence. This in turn continues to give r
Externí odkaz:
https://doaj.org/article/698aadb2c0e74fd79be7168ea44c90fd