Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sam A. Menzies"'
Autor:
Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
CRISPR/Cas9-mediated forward genetic screens and gene-trap mutagenesis screens in haploid cells are both powerful techniques to examine gene function. Here, the authors show the two approaches have high concordance and identify an uncharacterized gen
Externí odkaz:
https://doaj.org/article/ace455e4f2ee40ba943423c1d8c92321
Autor:
Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Publikováno v:
eLife, Vol 7 (2018)
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions,
Externí odkaz:
https://doaj.org/article/f84da21acd8c46149f6d640a9199b032
Publikováno v:
Innate Immunity
Innate Immunity, SAGE Publications, 2020, 26 (6), pp.459-472. ⟨10.1177/1753425920915507⟩
Innate Immunity, SAGE Publications, 2020, 26, pp.459-472. ⟨10.1177/1753425920915507⟩
Innate Immunity, Vol 26 (2020)
Innate Immunity, SAGE Publications, 2020, 26 (6), pp.459-472. ⟨10.1177/1753425920915507⟩
Innate Immunity, SAGE Publications, 2020, 26, pp.459-472. ⟨10.1177/1753425920915507⟩
Innate Immunity, Vol 26 (2020)
A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b27d5b4242b85df427f473dc3434f6
http://europepmc.org/articles/PMC7491238
http://europepmc.org/articles/PMC7491238
Autor:
Dick J. H. van den Boomen, James A. Nathan, Anna S Dickson, Richard T. Timms, Paul J. Lehner, Norbert Volkmar, Sam A. Menzies
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a987de26e34bf8224ce1d2293950d5
https://elifesciences.org/articles/40009
https://elifesciences.org/articles/40009
Autor:
Stephanie J. Popa, Kevin Moreau, Anna Petrunkina Harrison, Paul J. Lehner, Sam A. Menzies, Natalia Savinykh, Sarah E. Stewart
Galectins are a family of lectin binding proteins expressed both intracellularly and extracellularly. Galectin-3 (Gal-3, also known as LGALS3) is expressed at the cell surface; however, Gal-3 lacks a signal sequence, and the mechanism of Gal-3 transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa382fbe1465c5c0b58d4a4912a5fc62
https://www.repository.cam.ac.uk/handle/1810/270047
https://www.repository.cam.ac.uk/handle/1810/270047
Autor:
Richard T, Timms, Sam A, Menzies, Iva A, Tchasovnikarova, Lea C, Christensen, James C, Williamson, Robin, Antrobus, Gordon, Dougan, Lars, Ellgaard, Paul J, Lehner
Publikováno v:
Nature Communications
The application of forward genetic screens to cultured human cells represents a powerful method to study gene function. The repurposing of the bacterial CRISPR/Cas9 system provides an effective method to disrupt gene function in mammalian cells, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2665d7c0c579e48893e9809abbd0e60d
https://pubmed.ncbi.nlm.nih.gov/27283361
https://pubmed.ncbi.nlm.nih.gov/27283361
Autor:
Vanessa Clark, Isidro Hötzel, Jennifer Johnston, Siddharth Sukumaran, Dionysos Slaga, Teiko Sumiyoshi, Genee Lee, Sam A. Menzies, McCarty Luke, Rin Nakamura, Elizabeth Luis, John R. James, Teemu T. Junttila, Dimitry M. Danilenko, Ji Li, Danielle DiCara, Klara Totpal, Nicola J. Stagg, Diego Ellerman, Zhengmao Ye, Ryan Cook, Michael J. Harris
Publikováno v:
Blood. 128:4475-4475
Bispecific antibodies that retarget cytotoxic T cell activity to kill cancer cells are currently under clinical evaluation. However, the molecular mechanism for how CD3-bispecific antibodies 'trigger' intracellular T cell signaling is not known. We d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086180618e013e3dcd41264310ffb518
https://doi.org/10.1182/blood.v128.22.4475.4475
https://doi.org/10.1182/blood.v128.22.4475.4475
Publikováno v:
Innate Immunity, Vol 26 (2020)
A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune respons
Externí odkaz:
https://doaj.org/article/d8149479e43e41288954e39bd1f60b79