Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sam A. Bruschi"'
Autor:
Maria T. Villar, John T. Pinto, Zoya V. Niatsetskaya, Boris F. Krasnikov, Patrick S. Callery, Sam A. Bruschi, Arthur J.L. Cooper, Antonio Artigues
Publikováno v:
Amino Acids. 41:7-27
Cysteine S-conjugate β-lyases are pyridoxal 5′-phosphate-containing enzymes that catalyze β-elimination reactions with cysteine S-conjugates that possess a good leaving group in the β-position. The end products are aminoacrylate and a sulfur-con
Autor:
Michael L. Adams, Robert H. Pierce, Ruedi Aebersold, Nelson Fausto, Steven P. Gygi, Sidney D. Nelson, Eric A. James, Sam A. Bruschi
Publikováno v:
Biochemistry. 41:6789-6797
Metabolism of the common industrial gas tetrafluoroethylene in mammals results in the formation of S-(1,1,2,2)-tetrafluoroethyl-L-cysteine (TFEC), which can be bioactivated by a mitochondrial C-S lyase commonly referred to as beta-lyase. The resultan
Publikováno v:
Biochemical Pharmacology. 62:1345-1353
S -(1,1,2,2-Tetrafluoroethyl)- l -cysteine (TFEC, the cysteine S -conjugate of tetrafluoroethylene) is an example of a nephrotoxic, halogenated cysteine S -conjugate. Toxicity results in part from the cysteine S -conjugate β-lyase(s)-catalyzed conve
Publikováno v:
Journal of Biological Chemistry. 268:23157-23161
The potent and site-selective nephrotoxicity of S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC) in vivo has been associated with difluorothioamidyl-L-lysine formation on critical mitochondrial target proteins. Dose-response studies in the Fischer 344
Autor:
Sam A. Bruschi, Richard J. Bull
Publikováno v:
Fundamental and Applied Toxicology. 21:366-375
Dichloroacetate (DCA) and trichloroacetate (TCA) are major by-products of drinking water chlorination. Recent experiments have shown that both of these compounds produce hepatic tumors in B6C3F1 mice. There was evidence that these effects may be asso
Autor:
Yun Yang, Patrick J. Hayden, Michael B. Fisher, James L. Stevens, Sam A. Bruschi, Anthony J. I. Ward, Deanne M. Dulik
Publikováno v:
Chemical Research in Toxicology. 6:223-230
Fluorinated nephrotoxic cysteine conjugates undergo bioactivation via the beta-lyase pathway to thionoacetyl fluorides (TAF), the putative reactive intermediates. The TAF derived from S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine (TFEC) difluorothionoacet
Autor:
SAM A. BRUSCHI, RICHARD J. BULL
Publikováno v:
Toxicological Sciences. 21:366-375
Publikováno v:
Current Protocols in Toxicology
Cysteine S-conjugate β-lyases are pyridoxal 5'-phosphate (PLP)-containing enzymes that catalyze the conversion of cysteine S-conjugates [RSCH(2)CH(NH(3) (+))CO(2) (-)] and selenium Se-conjugates [RSeCH(2)CH(NH(3) (+))CO(2) (-)] that contain a leavin
Autor:
Sam A. Bruschi
Publikováno v:
Drug Metabolism and Transport ISBN: 9781588293244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e502c38c677d3344f097059811fdc500
https://doi.org/10.1385/1-59259-832-3:197
https://doi.org/10.1385/1-59259-832-3:197
Autor:
Kevin J. Coe, Theo K. Bammler, Zhonghua Hu, Catalin E. Doneanu, Han Kiat Ho, Yankai Jia, Nelson Fausto, Qiuxia Gao, Sidney D. Nelson, Richard P. Beyer, Sam A. Bruschi
Previously, S -(1,1,2,2-tetrafluoroethyl)- l -cysteine (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, α-ketoglutarate dehydrogenase (αKGDH) subunits, heat sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d479948cd2fc792128b2e264bd62dae
http://hdl.handle.net/2318/29097
http://hdl.handle.net/2318/29097