Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Sam A. Booker"'
Autor:
Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has
Externí odkaz:
https://doaj.org/article/ae255dae432e41748c4459655b5be30f
Autor:
Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price, Thomas Pratt
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex is hypothesised
Externí odkaz:
https://doaj.org/article/94e25852ab114ae8b3fe8bb4a3c913b2
Autor:
Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t
Externí odkaz:
https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae
Autor:
Sam A. Booker, Aleksander P. F. Domanski, Owen R. Dando, Adam D. Jackson, John T. R. Isaac, Giles E. Hardingham, David J. A. Wyllie, Peter C. Kind
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysyn
Externí odkaz:
https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc102
Autor:
Aleksander P. F. Domanski, Sam A. Booker, David J. A. Wyllie, John T. R. Isaac, Peter C. Kind
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Somatosensory hypersensitivity in Fmr-1 knockout mice is thought to arise from an increase in cortical circuit excitability. Here, the authors report that the loss of precision of sensory encoding in the Layer 4 of barrel cortex is the primary develo
Externí odkaz:
https://doaj.org/article/ba220841587e4c75bd2141b3e2677e5b
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100336- (2021)
Summary: This protocol allows repeated whole-cell patch-clamp recordings from individual rodent CA1 hippocampal neurons, followed by immunohistological labeling of the axon initial segment. This overcomes the need to maintain whole-cell recordings ov
Externí odkaz:
https://doaj.org/article/0ab4d295f9524e6fa06ea36e67fa033b
Autor:
Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 107988- (2020)
Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segmen
Externí odkaz:
https://doaj.org/article/43e9885c0bb64e499d98b5c2d2ae7c83
Autor:
Sam A. Booker, Desiree Loreth, Annabelle L. Gee, Masahiko Watanabe, Peter C. Kind, David J.A. Wyllie, Ákos Kulik, Imre Vida
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 36-43 (2018)
Summary: Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subt
Externí odkaz:
https://doaj.org/article/49895c395e5e4b0d8d602a4c4d4fcaa0
Autor:
Sam A Booker, Harumi Harada, Claudio Elgueta, Julia Bank, Marlene Bartos, Akos Kulik, Imre Vida
Publikováno v:
eLife, Vol 9 (2020)
Information processing in cortical neuronal networks relies on properly balanced excitatory and inhibitory neurotransmission. A ubiquitous motif for maintaining this balance is the somatostatin interneuron (SOM-IN) feedback microcircuit. Here, we inv
Externí odkaz:
https://doaj.org/article/e6c553f7dc3b44f9b8dfa39ff941bd48
Publikováno v:
Alusi, G, Berry-Kravis, E, Nelson, D, Orefice, L L & Booker, S A 2022, ' Emerging therapeutic strategies for Fragile X Syndrome : Q &A ', ACS Chemical Neuroscience, vol. 13, no. 24, pp. 3544-3546 . https://doi.org/10.1021/acschemneuro.2c00674
Understanding how best to treat aspects of Fragile X syndrome has the potential to improve the quality of life of affected individuals. Such an effective therapy has, as yet, remained elusive. In this article, we ask those researching or affected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa364e72bb693df2c18fb04f746cbe57
https://hdl.handle.net/20.500.11820/e2c236d6-b517-4f1d-8ae4-9773466eb52f
https://hdl.handle.net/20.500.11820/e2c236d6-b517-4f1d-8ae4-9773466eb52f
