Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sam, de Blank"'
1
Akademický článek
A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery
Autor: Bernadette Jeremiasse, Ravian L van Ineveld, Veerle Bok, Michiel Kleinnijenhuis, Sam de Blank, Maria Alieva, Hannah R Johnson, Esmée J van Vliet, Amber L Zeeman, Lianne M Wellens, Gerard Llibre-Palomar, Mario Barrera Román, Alessia Di Maggio, Johanna F Dekkers, Sabrina Oliveira, Alexander L Vahrmeijer, Jan J Molenaar, Marc HWA Wijnen, Alida FW van der Steeg, Ellen J Wehrens, Anne C Rios
Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1495-1514 (2024)
Abstract Achieving complete tumor resection is challenging and can be improved by real-time fluorescence-guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is t
Externí odkaz: https://doaj.org/article/59beb6ac34b24791970db0bb11a508eb
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2
Akademický článek
Optimizing Nanopore sequencing-based detection of structural variants enables individualized circulating tumor DNA-based disease monitoring in cancer patients
Autor: Jose Espejo Valle-Inclan, Christina Stangl, Anouk C. de Jong, Lisanne F. van Dessel, Markus J. van Roosmalen, Jean C. A. Helmijr, Ivo Renkens, Roel Janssen, Sam de Blank, Chris J. de Witte, John W. M. Martens, Maurice P. H. M. Jansen, Martijn P. Lolkema, Wigard P. Kloosterman
Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Here, we describe a novel approach for rapid discovery of a set of tumor-specific genomic structural variants (SVs), based on a combination of low coverage cancer genome sequencing using Oxford Nanopore with an SV calling and filtering pipel
Externí odkaz: https://doaj.org/article/dc2d84df5339442da6944319858a489d
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3
Akademický článek
Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing
Autor: Christina Stangl, Sam de Blank, Ivo Renkens, Liset Westera, Tamara Verbeek, Jose Espejo Valle-Inclan, Rocio Chamorro González, Anton G. Henssen, Markus J. van Roosmalen, Ronald W. Stam, Emile E. Voest, Wigard P. Kloosterman, Gijs van Haaften, Glen R. Monroe
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Fusion genes are a hallmarks of cancer, though breakpoint-position promiscuity restricts diagnostic detection. Here, the authors present FUDGE, a CRISPR-Cas9-based enrichment strategy for nanopore sequencing to identify target fusions irrespective of
Externí odkaz: https://doaj.org/article/e33d69e505f647c4a248cf888947cfbb
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4
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D
Autor: Maria Alieva, Frank L. Bos, Anne C. Rios, Ellen J. Wehrens, Johanna F. Dekkers, Michiel Kleinnijenhuis, Hannah Johnson, Jarno Drost, Clara Martínez Mir, Raimond Heukers, Mario Barrera Roman, Sam de Blank, Esmée J. van Vliet, Ravian L. van Ineveld, Susana M. Chuva de Sousa Lopes
Publikováno v: Nature Biotechnology
Nature Biotechnology, 39(10), 1239-1245. NATURE RESEARCH
Despite advances in three-dimensional (3D) imaging, it remains challenging to profile all the cells within a large 3D tissue, including the morphology and organization of the many cell types present. Here, we introduce eight-color, multispectral, lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bda6aec3ffafefa2656c82b7b58eca
https://doi.org/10.1038/s41587-021-00926-3
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6
Optimizing Nanopore sequencing-based detection of structural variants enables individualized circulating tumor DNA-based disease monitoring in cancer patients
Autor: Chris J. de Witte, Roel Janssen, Wigard P. Kloosterman, Martijn P. Lolkema, Christina Stangl, Markus J. van Roosmalen, Jose Espejo Valle-Inclan, Anouk C. de Jong, Jean C. A. Helmijr, Sam de Blank, Maurice P.H.M. Jansen, Ivo Renkens, John W.M. Martens, Lisanne F. van Dessel
Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Genome Medicine
Genome Medicine, 13(1):86. BioMed Central Ltd.
Here, we describe a novel approach for rapid discovery of a set of tumor-specific genomic structural variants (SVs), based on a combination of low coverage cancer genome sequencing using Oxford Nanopore with an SV calling and filtering pipeline. We a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff550e7faf0cabd18541ddbcfca0781
https://doi.org/10.1186/s13073-021-00899-7
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7
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D
Autor: Ravian L, van Ineveld, Michiel, Kleinnijenhuis, Maria, Alieva, Sam, de Blank, Mario, Barrera Roman, Esmée J, van Vliet, Clara, Martínez Mir, Hannah R, Johnson, Frank L, Bos, Raimond, Heukers, Susana M, Chuva de Sousa Lopes, Jarno, Drost, Johanna F, Dekkers, Ellen J, Wehrens, Anne C, Rios
Publikováno v: Nature biotechnology. 39(10)
Despite advances in three-dimensional (3D) imaging, it remains challenging to profile all the cells within a large 3D tissue, including the morphology and organization of the many cell types present. Here, we introduce eight-color, multispectral, lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e361d7d33bf4d921439a4a12533196f5
https://pubmed.ncbi.nlm.nih.gov/36045261
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