Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Sam, Hay"'
Autor:
Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Directed evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can
Externí odkaz:
https://doaj.org/article/44c22094b4a04ee98c938f54110c8603
Autor:
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J. Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O. Johannissen, Colin W. Levy, Laura N. Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schirò, Martin Weik, Nigel S. Scrutton, David Leys
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract CarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a seri
Externí odkaz:
https://doaj.org/article/001606f7b0874be9a4255441eb03bd98
Autor:
Matthew E. Thornton, Jake Hemsworth, Sam Hay, Patrick Parkinson, Stephen Faulkner, Louise S. Natrajan
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Macrocyclic lanthanide complexes have become widely developed due to their distinctive luminescence characteristics and wide range of applications in biological imaging. However, systems with sufficient brightness and metal selectivity can be difficu
Externí odkaz:
https://doaj.org/article/265514cbc5494dbdb5c337444e722a0d
Autor:
Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Isobutene is a high value gaseous alkene that is widely used as fuel additive and a chemical building block. Here, the authors report an alternative pathway for isobutene bioproduction by directed evolution of prenylated FMN-dependent ferulic acid de
Externí odkaz:
https://doaj.org/article/d96751d628eb4409a64c70cfafc944c0
Autor:
Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Gabriel R. Titchiner, Colin Levy, Sam Hay, David Leys
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the c
Externí odkaz:
https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd
Autor:
Mary Ortmayer, Florence J. Hardy, Matthew G. Quesne, Karl Fisher, Colin Levy, Derren J. Heyes, C. Richard A. Catlow, Sam P. de Visser, Stephen E. J. Rigby, Sam Hay, Anthony P. Green
Publikováno v:
JACS Au, Vol 1, Iss 7, Pp 913-918 (2021)
Externí odkaz:
https://doaj.org/article/7b1ea1dfa43042aa99a9e11ae0aa8261
Autor:
Youngchan Kim, Federico Bertagna, Edeline M. D’Souza, Derren J. Heyes, Linus O. Johannissen, Eveliny T. Nery, Antonio Pantelias, Alejandro Sanchez-Pedreño Jimenez, Louie Slocombe, Michael G. Spencer, Jim Al-Khalili, Gregory S. Engel, Sam Hay, Suzanne M. Hingley-Wilson, Kamalan Jeevaratnam, Alex R. Jones, Daniel R. Kattnig, Rebecca Lewis, Marco Sacchi, Nigel S. Scrutton, S. Ravi P. Silva, Johnjoe McFadden
Publikováno v:
Quantum Reports, Vol 3, Iss 1, Pp 80-126 (2021)
Understanding the rules of life is one of the most important scientific endeavours and has revolutionised both biology and biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range of complex and dynamic biolo
Externí odkaz:
https://doaj.org/article/c9a53bf8f9df40dfb0a9e770fea02dbf
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Examples of biosensors uti
Externí odkaz:
https://doaj.org/article/2eb78352ef57490eb897a4d2bb539a56
Autor:
Amy Crossley, Rebecca Crawshaw, Florence Hardy, Linus Johannissen, Thomas Lister, Emilie Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony Green
Directed evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can work in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117ee666f1e982b490975f8b9f5a7732
https://doi.org/10.21203/rs.3.rs-2922796/v1
https://doi.org/10.21203/rs.3.rs-2922796/v1
Publikováno v:
Cao, Y, Valdez-Moreira, J A, Hay, S, Smith, J M & De visser, S P 2023, ' Reactivity Differences of Trigonal Pyramidal Nonheme Iron(IV)-Oxo and Iron(III)-Oxo Complexes: Experiment and Theory. ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202300271
High-valent metal-oxo species play critical roles in enzymatic catalysis yet their properties are still poorly understood. In this work we report a combined experimental and computational study into biomimetic iron(IV)-oxo and iron(III)-oxo complexes