Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells

Autor: Noha, Ryad M., Abdelhameid, Mohammed.K., Ismail, M. Mohsen, Mohammed, Manal.R, Salwa, Elmeligie

Publikováno v: In European Journal of Medicinal Chemistry 1 January 2021 209

New synthetic approaches to thieno[3,2-d]pyrimidine and thieno[3,4-b]pyridine derivatives

Autor: Nadia A. Khalil, Salwa Elmeligie, Ahmed A. M. Ibraheem, Hala B. El-Nassan

Publikováno v: Chemical Papers. 74:2501-2514

In this work, 3-amino-4-cyano-2-thiophenecarboxamides 1a-k were used as versatile synthons for the preparation of thieno[3,2-d]pyrimidine-7-carbonitriles 2a-k and 4a-d as well as the unexpectedly prepared thieno[3,4-b]pyridine-7-carboxamides 5a-e. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6d2f6656b5b0a5283e8d40e0ce8e357
https://doi.org/10.1007/s11696-020-01089-2

Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists

Autor: Ashraf Bayoumi, Adel Ghiaty, Ahmed El-Morsy, Hamada Abul-Khair, Memy H. Hassan, Salwa Elmeligie

Publikováno v: Bulletin of Faculty of Pharmacy Cairo University, Vol 50, Iss 2, Pp 141-146 (2012)

This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1H-one (8), and many other newly synthesized compounds (9–14). The structure of the synthesized compounds was confirmed by elemental analysis and sp

Externí odkaz: https://doaj.org/article/f4b78364b52e4ea5b08d91fb28ad1152

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Autor: Asmaa M. AboulMagd, Tamer M. Abdelghany, Salwa Elmeligie, Sohair M Khojah, Khaled A.M. Abouzid, Tamer M. Ibrahim, Deena S. Lasheen

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1347-1367 (2019)

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca860537b28c27ab5de8ccb33345d9
https://doi.org/10.1080/14756366.2019.1642883

In vivo‐ and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors

Autor: Hamada S. Abulkhair, Hany E.A. Ahmed, Adel Ghiaty, Memy H. Hassan, Ashraf H. Bayoumi, Mohamed F. Zayed, Mona S. El-Zoghbi, Salwa Elmeligie, Eman N. Akl, Ahmed El-Morsy, Khaled El-Adl

Publikováno v: Archiv der Pharmazie. 354:2000449

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccf4a73e5ae83f94e540c7bc8813f1b
https://doi.org/10.1002/ardp.202000449