Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Salvatore Tozzi"'
Publikováno v:
Arzneimittelforschung. 50:345-352
Desloratadine (descarboethoxyloratadine, CAS 100643-71-8) is an active metabolite of loratadine (CAS 79794-75-5) that exhibits qualitatively similar pharmacodynamic activity with a relative oral potency in animals 2.5-4 times greater than loratadine.
Autor:
Xiomara Fernandez, Michel R. Corboz, Salvatore Tozzi, John A. Hey, Mary Ellen Monahan, Charles A. Rizzo
Publikováno v:
Autonomic and Autacoid Pharmacology. 23:79-93
1. The present study compared the effect of the administration of tachykinin NK1- and NK2-receptor antagonists alone and in combination on exogenous and endogenous tachykinin-induced contractions using three different guinea-pig airway preparations:
Publikováno v:
European Journal of Pharmacology. 294:329-335
We characterized the histamine H 3 receptors involved in the modulation of electrical field stimulated neurogenic contraction of guinea pig pulmonary artery sympathetic, and guinea pig ileum parasympathetic preparations. Simultaneous measures of elec
Autor:
Robert G. Aslanian, Steve Orlando, Lupo Andrew, Piwinski John J, William Kreutner, John A. Hey, Ashit K. Ganguly, Salvatore Tozzi, Neng-Yang Shih, Robert E. West, Michael J. Green
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(3)
Extensive structural modification of immepyr (+)-2 led to the discovery of trans-4-methyl-3-imidazoyl pyrrolidine (±)-3a as a potent and highly selective H3 agonist. The pyrroline (±)-3a was resolved, and its (+) enantiomer, Sch 50971 [(+)-3a], sho
Autor:
Mahesh J. Patel, Ronald Mierzwa, Michael A. Conover, Arthur King, Shirley A. Pomponi, Stephen J. Coval, Salvatore Tozzi, Mohindar S. Puar
Publikováno v:
Journal of natural products. 57(1)
The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-
Publikováno v:
Journal of Allergy and Clinical Immunology. 105:S382-S383
Publikováno v:
Journal of Allergy and Clinical Immunology. 105:S383
Publikováno v:
Agents and Actions. 14:590-597
SCH 29851 [8-chloro[6,11-dihydro-11-(1-carboethoxy-4-piperidylidene)- 5-H-benzo [5,6]cyclohepta[1,2-b]-pyridine] was discovered as part of a search for a new antihistamine without effects on the central nervous system (CHS). Antihistaminic potency an
Publikováno v:
Pharmacology. 37:187-194
HA 1004 is a calcium antagonist vasodilator that inhibits contraction in vascular smooth muscle and lowers arterial blood pressure. The effects of HA 1004 on guinea pig airway smooth muscle contraction were compared to the effects of the calcium anta
Publikováno v:
Agents and Actions. 4:264-270
Azatadine (6–11-dihydro-11-[1-methyl-4-piperclylidene]-5H{5,6}cyclohepta{1,2-b}pyridine maleate {1∶2}), a nitrogen analog of cyproheptadine has been studied for its antiallergy properties. It was compared in vivo and in vitro to cyproheptadine an