Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Salvatore Sanna Coccone"'
Autor:
Riccardo De Ricco, Francesca Rech, Valeria Onnis, Salvatore Sanna Coccone, Giusy Scalia, Cristina Marcozzi, Massimiliano Gavini, Sara Beni, Sara Giannini, Luca Nompari, Chiara Parlati, Claudia Magagnoli, Simona Cianetti, Francesco Berti
Publikováno v:
ACS Omega. 7:39875-39883
GlaxoSmithKline (GSK) is currently developing a fully liquid presentation to ease the administration of the licensed quadrivalent conjugate vaccine (Menveo) against meningococcal serogroup A, C, W, and Y (MenACWY) infections. Herein, we report a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4047ba9f1f3d0ababe1542723ecfa25c
https://doi.org/10.1021/acsomega.2c04013
https://doi.org/10.1021/acsomega.2c04013
Autor:
Raminta Venskutonyte?, Stefania Butini, Salvatore Sanna Coccone, Sandra Gemma, Margherita Brindisi, Vinod Kumar, Egeria Guarino, Samuele Maramai, Salvatore Valenti, Ahmad Amir, Elena Anto?n Valade?s, Karla Frydenvang, Jette S. Kastrup, Giuseppe Campiani, Darryl S. Pickering, BRINDISI, MARGHERITA, NOVELLINO, ETTORE
Publikováno v:
Journal of Medicinal Chemistry. 54:4793-4805
The physiological function of kainate receptors (GluK1-GluK5) in the central nervous system is not fully understood yet. With the aim of developing potent and selective GluK1 ligands, we have synthesized a series of new thiophene-based GluK1 agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8907ae9e9d48e590bc8ce843a93e0617
https://doi.org/10.1021/jm2004078
https://doi.org/10.1021/jm2004078
Publikováno v:
Organic Process Research & Development. 18:699-708
A practical and scalable route to the SMO antagonist SEN826 1 is described herein, including the discussion of an alternative approach to the synthesis of the target molecule. The optimized route consists of five chemical steps. A new and efficient a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d348b1c5f978bdd85c3fef7d3001d680
https://doi.org/10.1021/op4002092
https://doi.org/10.1021/op4002092
Publikováno v:
Organic Process Research & Development. 17:1042-1051
A practical and scalable route to the Wnt inhibitor SEN461 1 is described herein. The optimized route consists of nine chemical steps. The intermediates are solids and were isolated by filtrations....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f8997dd4291ab0492843fdf452158d
https://doi.org/10.1021/op400145w
https://doi.org/10.1021/op400145w
Autor:
Matteo Betti, Salvatore Sanna Coccone, Paul H. Wiedenau, Giulio Castagnoli, Alessandro Panico
Publikováno v:
Organic Process Research & Development. 16:1739-1745
A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Krohnke reaction was developed, significantl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8934033e3efa1cfdf71aadb9730dd9
https://doi.org/10.1021/op300170q
https://doi.org/10.1021/op300170q
Autor:
Salvatore Sanna Coccone, Luisa Chiasserini, Ettore Novellino, Maria Altarelli, Sandra Gemma, Caterina Camodeca, Stefania Butini, Giuseppe Campiani, Vinod Kumar, Giovanni Delogu, Luisa Savini, Pierangela Tripaldi, Sandra Clarizio
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:6063-6072
A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25microg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb01c3620d271a31a8fda5941618c7d
https://doi.org/10.1016/j.bmc.2009.06.051
https://doi.org/10.1016/j.bmc.2009.06.051
Autor:
Margherita Brindisi, Simone Brogi, Bhupendra Prasad Joshi, Salvatore Sanna Coccone, Stefania Butini, Ettore Novellino, Nicoletta Basilico, Silvia Parapini, Sandra Gemma, Giuseppe Campiani
We report herein the generation and validation of a 3D-QSAR model based on a set of antimalarials previously described by us and characterized by a clotrimazole-based pharmacophore. A novel series of derivatives was synthesized and showed activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce1ee7cf94a5d253125ddd1d96f250
http://hdl.handle.net/11365/981876
http://hdl.handle.net/11365/981876
Autor:
Beatrice Gorelli, Salvatore Sanna Coccone, Giovanna Guiso, Stefania Lamponi, Maria Cruz Bonache de Marcos, Simone Brogi, Nicoletta Basilico, Bhupendra Prasad Joshi, Matteo Bernetti, Simona Saponara, Ettore Novellino, Caterina Camodeca, Silvio Caccia, Matthias Rottmann, Vittoria Moretti, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Reto Brun, Donatella Taramelli, Rowena E. Martin, Luisa Savini, Robert L. Summers, Silvia Parapini
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development of a novel antimalarial drug that combines the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f7e9da7c58c7c24defdab5e0bb423a
http://hdl.handle.net/11588/573693
http://hdl.handle.net/11588/573693
Autor:
Salvatore Sanna Coccone, Silvia Parapini, Simone Brogi, Nicoletta Basilico, Donatella Taramelli, Margherita Brindisi, Ettore Novellino, Vittoria Moretti, Giuseppe Campiani, Stefania Butini, Sandra Gemma, Sanil Kunjir
Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5580e3fc83429fa698488f8ed9e843fa
http://hdl.handle.net/11365/19027
http://hdl.handle.net/11365/19027
Autor:
Orazio Taglialatela-Scafati, Salvatore Sanna Coccone, Ettore Novellino, Giuseppe Campiani, Francesc Marti, Emanuele Gabellieri, Stefania Butini, Sandra Gemma
The first synthesis of the marine endoperoxide 9,10-dihydroplakortin, of its C10-desethyl analogue, and of their corresponding C6 epimers is described. Stereogenic centers at C4 and at the lateral chain have been stereoselectively synthesized through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3104dafad2f7e9145ea1e2468c50da34
http://hdl.handle.net/11588/364339
http://hdl.handle.net/11588/364339