Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Salvatore Pacifico"'
Autor:
Valentina Albanese, Chiara Roccatello, Salvatore Pacifico, Remo Guerrini, Delia Preti, Silvia Gentili, Matteo Tegoni, Maurizio Remelli, Denise Bellotti, Jonathan Amico, Giancarlo Gorgoni, Emiliano Cazzola
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-25 (2024)
Abstract Background Positron emission tomography (PET) is a highly sensitive method that provides fine resolution images, useful in the field of clinical diagnostics. In this context, Zirconium-89 (89Zr)-based imaging agents have represented a great
Externí odkaz:
https://doaj.org/article/8b015e677f7b462d9caf7d52aac9d576
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Davide Proietto, Beatrice Dallan, Eleonora Gallerani, Valentina Albanese, Sian Llewellyn-Lacey, David A. Price, Victor Appay, Salvatore Pacifico, Antonella Caputo, Francesco Nicoli, Riccardo Gavioli
Publikováno v:
Vaccines, Vol 11, Iss 1, p 154 (2023)
Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated in vitro approach to determine
Externí odkaz:
https://doaj.org/article/03b75c933d1c4bab8dea15e267234d4d
Autor:
Eleonora Gallerani, Davide Proietto, Beatrice Dallan, Marco Campagnaro, Salvatore Pacifico, Valentina Albanese, Erika Marzola, Peggy Marconi, Antonella Caputo, Victor Appay, Riccardo Gavioli, Francesco Nicoli
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute
Externí odkaz:
https://doaj.org/article/b126d612f49b46eabf751647fe897224
Autor:
Joaquim Azevedo Neto, Chiara Ruzza, Chiara Sturaro, Davide Malfacini, Salvatore Pacifico, Nurulain T. Zaveri, Girolamo Calò
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics. In v
Externí odkaz:
https://doaj.org/article/c09d6558a3ed44a58c51eb5522a1b34e
Autor:
Francesco Nicoli, Salvatore Pacifico, Eleonora Gallerani, Erika Marzola, Valentina Albanese, Valentina Finessi, Sian Llewellyn-Lacey, David A. Price, Victor Appay, Peggy Marconi, Remo Guerrini, Antonella Caputo, Riccardo Gavioli
Publikováno v:
Vaccines, Vol 9, Iss 5, p 526 (2021)
Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed
Externí odkaz:
https://doaj.org/article/0533319262404f9fa05e34762a961687
Autor:
Anna Fantinati, Sara Bianco, Remo Guerrini, Severo Salvadori, Salvatore Pacifico, Maria Camilla Cerlesi, Girolamo Calo, Claudio Trapella
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract A diastereoselective synthesis of the title compound as a single E diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexane-dihydropyrano[3,4-b]-indole]-amine framework through
Externí odkaz:
https://doaj.org/article/f9793336055c4632b76511f6e3164571
Autor:
Giulia Breveglieri, Salvatore Pacifico, Cristina Zuccato, Lucia Carmela Cosenza, Shaiq Sultan, Elisabetta D’Aversa, Roberto Gambari, Delia Preti, Claudio Trapella, Remo Guerrini, Monica Borgatti
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7426 (2020)
The screening of chemical libraries based on cellular biosensors is a useful approach to identify new hits for novel therapeutic targets involved in rare genetic pathologies, such as β-thalassemia and sickle cell disease. In particular, pharmacologi
Externí odkaz:
https://doaj.org/article/f04a26e2f97442bfa8f142ec241b965c
Autor:
Gaetano Marverti, Gaia Gozzi, Eleonora Maretti, Angela Lauriola, Leda Severi, Francesca Sacchetti, Lorena Losi, Salvatore Pacifico, Stefania Ferrari, Glauco Ponterini, Eliana Leo, Maria Paola Costi, Domenico D’Arca
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4452 (2020)
There is currently no effective long-term treatment for ovarian cancer (OC) resistant to poly-chemotherapy regimens based on platinum drugs. Preclinical and clinical studies have demonstrated a strong association between development of Pt-drug resist
Externí odkaz:
https://doaj.org/article/e4ff2cef7f514de3bb34dac9bd7741c7
Autor:
Francesco Nicoli, Eleonora Gallerani, Mariaconcetta Sicurella, Salvatore Pacifico, Aurelio Cafaro, Barbara Ensoli, Peggy Marconi, Antonella Caputo, Riccardo Gavioli
Publikováno v:
Vaccines, Vol 8, Iss 2, p 274 (2020)
The development of therapeutic strategies to control the reactivation of the Herpes Simplex Virus (HSV) is an unaddressed priority. In this study, we evaluated whether Tat, a HIV-1 protein displaying adjuvant functions, could improve previously estab
Externí odkaz:
https://doaj.org/article/d0c1b753ccaa4fb6acb40d33f15d6684