Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Salvatore Mirabile"'
Autor:
Salvatore Mirabile, Valeria D’Angelo, Maria Paola Germanò, Shiva Pouramin Arabi, Valentina Parisi, Francesco Maria Raimondo, Emanuele Rosa
Publikováno v:
Plants, Vol 13, Iss 1, p 34 (2023)
In the present study, we focused our attention on Crataegus laciniata Ucria (Rosaceae), which is wild growing in western Sicily (Italy). The chemical profile of the C. laciniata flower’s (CLF) ethanolic (70%) extract showed the presence of both C-f
Externí odkaz:
https://doaj.org/article/663fc019fea3419d8d2452e15b87e3fc
Autor:
Salvatore Mirabile, Laura Ielo, Lisa Lombardo, Federico Ricci, Rosaria Gitto, Maria Paola Germanò, Vittorio Pace, Laura De Luca
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7944 (2023)
Tyrosinase (EC 1.14.18.1) is implicated in melanin production in various organisms. There is a growing body of evidence suggesting that the overproduction of melanin might be related to several skin pigmentation disorders as well as neurodegenerative
Externí odkaz:
https://doaj.org/article/592de67637fe4865b73522aad3c2ad4c
Autor:
Salvatore Mirabile, Maria Paola Germanò, Antonella Fais, Lisa Lombardo, Federico Ricci, Sonia Floris, Anna Cacciola, Antonio Rapisarda, Rosaria Gitto, Laura De Luca
Publikováno v:
ChemMedChem. 17(21)
Melanin biosynthesis is enzymatically regulated by tyrosinase (TYR, EC 1.14.18.1), which is efficiently inhibited by natural and synthetic phenols, demonstrating potential therapeutic application for the treatment of several human diseases. Herein we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdb668654c244fcaab88ec2ac06873d
https://pubmed.ncbi.nlm.nih.gov/36093940
https://pubmed.ncbi.nlm.nih.gov/36093940
Autor:
Antonio Rapisarda, Laura De Luca, Sonia Floris, Yael Pazy, Antonella Fais, Maria Paola Germanò, Batel Deri, Ayelet Fishman, Serena Vittorio, Rosaria Gitto, Salvatore Mirabile, Laura Ielo, Simone Ronsisvalle
Publikováno v:
European Journal of Medicinal Chemistry. 178:380-389
The development of Tyrosinase inhibitors (TYRIs) could represent an efficacious strategy for pharmacological intervention on skin pathologies related to aberrant production of melanin. Based on in silico studies we designed and tested a library of tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c023aa5155f19fac899affb42d24ae0d
https://doi.org/10.1016/j.ejmech.2019.06.019
https://doi.org/10.1016/j.ejmech.2019.06.019
Autor:
Laura, Ielo, Margherita, Miele, Veronica, Pillari, Raffaele, Senatore, Salvatore, Mirabile, Rosaria, Gitto, Wolfgang, Holzer, Andrés R, Alcántara, Vittorio, Pace
Publikováno v:
Organicbiomolecular chemistry. 19(9)
The intrinsic degradative α-elimination of Li carbenoids somehow complicates their use in synthesis as C1-synthons. Nevertheless, we herein report how boosting such an α-elimination is a straightforward strategy for accomplishing controlled ring-op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9973cedf4c39cbe367111ab515debe4e
https://pubmed.ncbi.nlm.nih.gov/33599644
https://pubmed.ncbi.nlm.nih.gov/33599644
Autor:
Laura Ielo, Francesca Pintus, Serena Vittorio, Rosaria Gitto, Maria Paola Germanò, Ilenia Adornato, Laura De Luca, Antonio Rapisarda, Antonella Fais, Salvatore Mirabile
Publikováno v:
Chemmedchem
There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9822748bb68f28e28c121c16c624a826
http://hdl.handle.net/2318/1835397
http://hdl.handle.net/2318/1835397
Autor:
Veronica Pillari, Laura Ielo, Andrés R. Alcántara, Rosaria Gitto, Wolfgang Holzer, Raffaele Senatore, Margherita Miele, Salvatore Mirabile, Vittorio Pace
The intrinsic degradative α-elimination of Li carbenoids somehow complicates their use in synthesis as C1-synthons. Nevertheless, we herein report how boosting such an α-elimination is a straightforward strategy for accomplishing controlled ring-op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd128b03043791f1e63d80320f016ede
http://hdl.handle.net/2318/1779576
http://hdl.handle.net/2318/1779576
Autor:
Serena Vittorio, Rosaria Gitto, Antonio Rapisarda, Salvatore Mirabile, Laura De Luca, Maria Rosa Buemi, Maria Paola Germanò, Francesca Pintus, Antonella Fais
Tyrosinase (TYR, EC 1.14.18.1) plays a pivotal role in mammalian melanogenesis and enzymatic browning of plant-derived food. Therefore, tyrosinase inhibitors (TYRIs) can be of interest in cosmetics and pharmaceutical industries as depigmentation comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8bce75a97bdbdd274d1e85f161cecb
https://hdl.handle.net/11570/3203799
https://hdl.handle.net/11570/3203799
Autor:
Serena Vittorio, Rosaria Gitto, Antonio Rapisarda, Sonia Floris, Laura Ielo, Salvatore Mirabile, Laura De Luca, Antonella Fais, Maria Paola Germanò
Tyrosinase is a type-3 copper protein involved in the biosynthesis of melanin pigments; therefore, the inhibition of its enzymatic activity represents a promising strategy for the treatment of hyperpigmentation-related disorders. To address this poin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea917b93804da0a581bf587fc96cfef0
http://hdl.handle.net/11570/3203780
http://hdl.handle.net/11570/3203780