Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Salvatore Milite"'
Autor:
Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J. Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William C. H. Cross, Giulio Caravagna
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-40 (2024)
Abstract Copy number alterations (CNAs) are among the most important genetic events in cancer, but their detection from sequencing data is challenging because of unknown sample purity, tumor ploidy, and general intra-tumor heterogeneity. Here, we pre
Externí odkaz:
https://doaj.org/article/58afabce18a849ecb410852f49a33e9f
Autor:
Jonathan Mitchell, Salvatore Milite, Jack Bartram, Susan Walker, Nadezda Volkova, Olena Yavorska, Magdalena Zarowiecki, Jane Chalker, Rebecca Thomas, Luca Vago, Alona Sosinsky, Giulio Caravagna
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The unexpected contamination of normal samples with tumour cells reduces variant detection sensitivity, compromising downstream analyses in canonical tumour-normal analyses. Leveraging whole-genome sequencing data available at Genomics Engla
Externí odkaz:
https://doaj.org/article/6982e7ee6f034f499acae6eb4a4c3fee
Autor:
Lucrezia Patruno, Salvatore Milite, Riccardo Bergamin, Nicola Calonaci, Alberto D'Onofrio, Fabio Anselmi, Marco Antoniotti, Alex Graudenzi, Giulio Caravagna
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011557 (2023)
Single-cell RNA and ATAC sequencing technologies enable the examination of gene expression and chromatin accessibility in individual cells, providing insights into cellular phenotypes. In cancer research, it is important to consistently analyze these
Externí odkaz:
https://doaj.org/article/711143dbbcf84508bb43f4555ba5999a
Autor:
Erika Tissino, Nicola Calonaci, Federico Pozzo, Filippo Vit, Annalisa Gaglio, Lodovico Terzi DI Bergamo, Tamara Bittolo, Francesca Maria Rossi, Robel Papotti, Ilaria Catarossi, Eva Zaina, Paola Nanni, Riccardo Bergamin, Leonardo Egidi, Giovanni Santacatterina, Salvatore Milite, Maria Ilaria Del Principe, Roberta Laureana, Jacopo Olivieri, Francesco Zaja, Annalisa Chiarenza, Davide Rossi, Riccardo Bomben, Valter Gattei, Antonella Zucchetto, Giulio Caravagna
Publikováno v:
HemaSphere, Vol 7, p e7042158 (2023)
Externí odkaz:
https://doaj.org/article/73e887b6f43d4d0188730e751f7b5a07
Autor:
Luis Zapata, Giulio Caravagna, Marc J. Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A. Chan, Trevor A. Graham, Andrea Sottoriva
Publikováno v:
Nature Genetics. 55:451-460
In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356 immune-checkpoint-treated metastases using immune dN/dS, the ratio of nonsynonymous to synonymous mutations in the immunope
Autor:
Erika Tissino, Nicola Calonaci, Federico Pozzo, Gabriela Forestieri, Lodovico Terzi Di Bergamo, Filippo Vit, Annalisa Gaglio, Riccardo Bergamin, Salvatore Milite, Stefano Cozzini, Maria Ilaria Del Principe, Roberta Laureana, Annalisa Chiarenza, Jacopo Olivieri, Francesco Zaja, Cristoforo Fabbris, Valentina Lupato, Riccardo Bomben, Davide Rossi, Valter Gattei, Antonella Zucchetto, Giulio Caravagna
Publikováno v:
Blood. 140:9844-9846
Autor:
Alvaro H. Ingles Russo Garces, Salvatore Milite, Javier Fernandez-Mateos, Bingjie Chen, Lisa Pickard, Adam Stewart, Sara Diaz Sanchez, Rachel Lau, Erica Oliveira, Susana Banerjee, Andrea Sottoriva, Udai Banerji
Publikováno v:
Cancer Research. 82:3790-3790
Background High-grade serous ovarian cancer (HGSOC) is characterized by extensive intratumoral heterogeneity, which is associated with drug resistance. Our aim was to study the effects of drugs used in the treatment of HGSOC - carboplatin (C), paclit
Computational validation of clonal and subclonal copy number alterations from bulk tumour sequencing
Autor:
Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William CH Cross, Giulio Caravagna
Cancer is a global health issue that places enormous demands on healthcare systems. Basic research, the development of targeted treatments, and the utility of DNA sequencing in clinical settings, have been significantly improved with the introduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90bf93d9fcbccdf1f2ea0af71003300a
https://doi.org/10.1101/2021.02.13.429885
https://doi.org/10.1101/2021.02.13.429885
MotivationCancers are composed by several heterogeneous subpopulations, each one harbouring different genetic and epigenetic somatic alterations that contribute to disease onset and therapy response. In recent years, copy number alterations leading t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7236e1d5fc1d331a4101d7919ede05e
https://doi.org/10.1101/2021.02.02.429335
https://doi.org/10.1101/2021.02.02.429335
Autor:
Germana Tognon, Andrea Sambugaro, Giuseppe Benvenuto, Flaminia Zane, Matteo Ciciani, Robert Fruscio, Martina Delle Marchette, Sergio Marchini, Chiara Romualdi, Antonella Ravaggi, Eliana Bignotti, Fulvio Borella, Salvatore Milite, Luca Beltrame, Paolo Martini, Franco Odicino, Lara Paracchini, Maurizio D'Incalci, Dionyssios Katsaros, Enrica Calura
Publikováno v:
Cells
Volume 8
Issue 12
Volume 8
Issue 12
Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6290083c39b1b03c70fb836bc8f409c1
http://hdl.handle.net/11379/533944
http://hdl.handle.net/11379/533944