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pro vyhledávání: '"Salvatore J. De Salva"'
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 10:95-104
The Draize rabbit eye test has been used for over 40 years to determine the eye irritation potential of materials. To minimize the use of animals in safety testing, investigators have been searching for alternatives to the Draize test. One alternativ
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 10:105-113
Previous research has shown that the chorioallantoic membrane (CAM) of a fertile hen's egg can be a useful model for predicting eye irritation potential. However, the specific test procedure utilized will affect the degree of correlation between the
Publikováno v:
Contact Dermatitis. 8:200-203
D & C Yellow No. 11 was found to be a skin sensitizer in guinea pigs at an elicitation concentration of 10.0% in ethanol but not at 1.0 and 3.0%. Sensitization was induced with a 50% suspension in ethanol. D & C Yellow No. 10, the disodium salt of th
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 7:295-307
Phototoxicity is a skin-cell damage response that follows exposure, in many instances, to a juxtapositional combination of certain chemicals and ultraviolet A (UVA) light. Many known phototoxins are fragrances or components of fragrances. Because of
Autor:
Salvatore J. De Salva
Publikováno v:
Experimental Biology and Medicine. 100:581-583
SummaryThe effects of total hypophysectomy, adenohypophysectomy and neurohypo-physectomy on EST were compared in rats. 1. Hypophysectomy and adenohypophysectomy severely lowered EST and reduced body and adrenal weight. 2. Neurohypophysectomy, althoug
Publikováno v:
Scopus-Elsevier
Primary irritancy in human and animal skin is characterized by an inflammatory reaction mediated, in part, by membrane-derived arachidonate metabolites. One of the mechanisms of this reaction was investigated in cultured mammalian cells using three s