Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Salvatore, Spina"'
Autor:
Niyatee Samudra, Hannah Lerner, Leslie Yack, Christine M. Walsh, Heidi E. Kirsch, Kiwamu Kudo, Claire Yballa, Renaud La Joie, Maria L. Gorno‐Tempini, Salvatore Spina, William W. Seeley, Thomas C. Neylan, Bruce L. Miller, Gil D. Rabinovici, Adam Boxer, Lea T. Grinberg, Katherine P. Rankin, Srikantan S. Nagarajan, Kamalini G. Ranasinghe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 525-535 (2024)
Abstract Introduction Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), are the most common four‐repeat tauopathies (4RT), and both frequently occur with varying degree of Alzheimer's disease (AD) copathology. Intriguingly,
Externí odkaz:
https://doaj.org/article/c6a7c6da131a41e9a2a910656dc41c1d
Autor:
Stefanie D. Pina‐Escudero, Renaud La Joie, Salvatore Spina, Ji‐Hye Hwang, Zachary A. Miller, Eric J. Huang, Harli Grant, Nidhi S. Mundada, Adam L. Boxer, Maria Luisa Gorno‐Tempini, Howard J. Rosen, Joel H. Kramer, Bruce L. Miller, William W. Seeley, Gil D. Rabinovici, Lea Tenenholz Grinberg
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.
Externí odkaz:
https://doaj.org/article/3a35a738074541e6ac5d67e4c35f4e1e
Autor:
Salvatore Spina
Publikováno v:
Umanistica Digitale, Iss 16, Pp 125-140 (2023)
This article examines the impact of Artificial Intelligence on the archival heritage digitization processes, specifically regarding the manuscripts’ automatic transcription, their correction, and normalization. It highlights how digitality has comp
Externí odkaz:
https://doaj.org/article/dfa42036af714afd9b925ee2f964d4c8
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
Salvatore Spina
Publikováno v:
Umanistica Digitale, Iss 14, Pp 163-181 (2023)
The Paternò Castello (Princes of Biscari) Archive, preserved at the State Archive of Catania – amongst one of the most crucial family archives – is of the complex historical heritage that can lead historians to write the history of Catania, of h
Externí odkaz:
https://doaj.org/article/e4acd2aa04074346b0f1a6344a4dc356
Autor:
Salvatore Spina
Publikováno v:
Umanistica Digitale, Iss 13, Pp 183-197 (2022)
Reconsidering “territories government” in the Modern Age is about analyzing a weak and widespread reality of power, especially when historians have to reconstruct the history of massive emergencies (such as eruptions, earthquakes, epidemics) even
Externí odkaz:
https://doaj.org/article/b564582dde00491f9aa3e6c3c7eab5a4
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Externí odkaz:
https://doaj.org/article/1474593e97d94a4ab73bc2bde059f30e
Autor:
Salvatore Spina
Publikováno v:
Journal of Open Humanities Data, Vol 10, Pp 11-11 (2024)
The dataset contains metadata describing the Princes of Biscari (Paternò Castello) correspondence, one of the most important noble families in Sicily during the modern era. The dataset was created with the digitization of letters preserved in the Bi
Externí odkaz:
https://doaj.org/article/b1f935d2ca7e4cd38e05d35090d03fea
Autor:
Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, Martina de Majo, Cristina Mora, Jessica Blumenfeld, Alissa N. Li, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Erik M. Ullian, Matthew F. Krummel, Arnold R. Kriegstein, Eric J. Huang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical cir
Externí odkaz:
https://doaj.org/article/7f87fa9f28bd4ee9be391db5a7643359
Autor:
Miguel A. Minaya, Sidhartha Mahali, Abhirami K. Iyer, Abdallah M. Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L. Nana, William W. Seeley, Salvatore Spina, Lea T. Grinberg, Oscar Harari, Celeste M. Karch
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across
Externí odkaz:
https://doaj.org/article/5c8300a5cf374c2ba727c09cab44b1dd