Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Salvatore, Spicuglia"'
Autor:
Marin Truchi, Caroline Lacoux, Cyprien Gille, Julien Fassy, Virginie Magnone, Rafael Lopes Goncalves, Cédric Girard-Riboulleau, Iris Manosalva-Pena, Marine Gautier-Isola, Kevin Lebrigand, Pascal Barbry, Salvatore Spicuglia, Georges Vassaux, Roger Rezzonico, Michel Barlaud, Bernard Mari
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Single-cell CRISPR-based transcriptome screens are potent genetic tools for concomitantly assessing the expression profiles of cells targeted by a set of guides RNA (gRNA), and inferring target gene functions from the observed perturbations. However,
Externí odkaz:
https://doaj.org/article/961d2c23e9cc4a02a8c14cc9b774b873
Autor:
Lucien Courtois, Aurélie Cabannes-Hamy, Rathana Kim, Marine Delecourt, Antoine Pinton, Guillaume Charbonnier, Melanie Feroul, Charlotte Smith, Giulia Tueur, Cecile Pivert, Estelle Balducci, Mathieu Simonin, Salvatore Spicuglia, Nicolas Boissel, Guillaume Andrieu, Vahid Asnafi, Philippe Rousselot, Ludovic Lhermitte
Publikováno v:
HemaSphere, Vol 7, p e3064078 (2023)
Externí odkaz:
https://doaj.org/article/9e3b71903d194ef09b166a0e946bdd75
Autor:
Bernard S. Stikker, Grégoire Stik, Antoinette F. van Ouwerkerk, Lianne Trap, Salvatore Spicuglia, Rudi W. Hendriks, Ralph Stadhouders
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We perform an epigenomic dissection of 3p21.31, identifying a CTCF-dependent tissue-specific 3
Externí odkaz:
https://doaj.org/article/c1a0d3a980af48e5a61bff91e9aff9ac
Autor:
Charlotte Smith, Ashish Goyal, Dieter Weichenhan, Eric Allemand, Anand Mayakonda, Umut Toprak, Anna Riedel, Estelle Balducci, Manisha Manojkumar, Anastasija Pejkovska, Oliver Mücke, Etienne Sollier, Ali Bakr, Kersten Breuer, Pavlo Lutsik, Olivier Hermine, Salvatore Spicuglia, Vahid Asnafi, Christoph Plass, Aurore Touzart
Publikováno v:
Haematologica, Vol 108, Iss 5 (2023)
T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur through diverse cis-alterations, including SIL-TAL1 microdeletions, tran
Externí odkaz:
https://doaj.org/article/6e9c05fc1a7f4ebda3d21c7b4a8a919f
Autor:
David Santiago-Algarra, Charbel Souaid, Himanshu Singh, Lan T. M. Dao, Saadat Hussain, Alejandra Medina-Rivera, Lucia Ramirez-Navarro, Jaime A. Castro-Mondragon, Nori Sadouni, Guillaume Charbonnier, Salvatore Spicuglia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Some promoters, termed Epromoters, can display enhancer activity and regulate distal genes in their endogenous context. Here the authors report the broad involvement of Epromoters in the coordinated activation of interferon (IFN) response. They show
Externí odkaz:
https://doaj.org/article/2a838a6dac1c4a42aac0c04facbcf0f8
Autor:
Samia Nisar, Magali Torres, Alassane Thiam, Bruno Pouvelle, Florian Rosier, Frederic Gallardo, Oumar Ka, Babacar Mbengue, Rokhaya Ndiaye Diallo, Laura Brosseau, Salvatore Spicuglia, Alioune Dieye, Sandrine Marquet, Pascal Rihet
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4849 (2022)
Genome-wide association studies for severe malaria (SM) have identified 30 genetic variants mostly located in non-coding regions. Here, we aimed to identify potential causal genetic variants located in these loci and demonstrate their functional acti
Externí odkaz:
https://doaj.org/article/17374f5dc20549af8146cd9929d48727
Autor:
Aurore Touzart, Nicolas Boissel, Mohamed Belhocine, Charlotte Smith, Carlos Graux, Mehdi Latiri, Ludovic Lhermitte, Eve-Lyne Mathieu, Françoise Huguet, Laurence Lamant, Pierre Ferrier, Norbert Ifrah, Elizabeth Macintyre, Hervé Dombret, Vahid Asnafi, Salvatore Spicuglia
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Cancer cells undergo massive alterations in their DNA methylation patterns which result in aberrant gene expression and malignant phenotypes. Abnormal DNA methylation is a prognostic marker in several malignancies, but its potential prognostic signif
Externí odkaz:
https://doaj.org/article/a9c77692f0464674b389bcbddd1eb795
Autor:
Darely Y. Gutiérrez-Reyna, Alejandra Cedillo-Baños, Linda A. Kempis-Calanis, Oscar Ramírez-Pliego, Lisa Bargier, Denis Puthier, Jose D. Abad-Flores, Morgane Thomas-Chollier, Denis Thieffry, Alejandra Medina-Rivera, Salvatore Spicuglia, Maria A. Santana
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and mortality rates. CD8+ T lymphocytes are responsible for the elimination of infected cells. Understanding the response of these cells to normal and high stimulat
Externí odkaz:
https://doaj.org/article/8c177a28a4f942e9a298502304fb2cdd
Autor:
Jaafar Alomairi, Anne M Molitor, Nori Sadouni, Saadat Hussain, Magali Torres, Wiam Saadi, Lan T M Dao, Guillaume Charbonnier, David Santiago-Algarra, Jean Christophe Andrau, Denis Puthier, Tom Sexton, Salvatore Spicuglia
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233191 (2020)
The Ikzf1 locus encodes the lymphoid specific transcription factor Ikaros, which plays an essential role in both T and B cell differentiation, while deregulation or mutation of IKZF1/Ikzf1 is involved in leukemia. Tissue-specific and cell identity ge
Externí odkaz:
https://doaj.org/article/c6babbb5c5134b56b0768caedee2e919
Autor:
Saadat Hussain, Nori Sadouni, Dominic van Essen, Lan T M Dao, Quentin Ferré, Guillaume Charbonnier, Magali Torres, Frederic Gallardo, Charles-Henri Lecellier, Tom Sexton, Simona Saccani, Salvatore Spicuglia
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2023, 51 (10), pp.4845-4866. ⟨10.1093/nar/gkad187⟩
Nucleic Acids Research, 2023, 51 (10), pp.4845-4866. ⟨10.1093/nar/gkad187⟩
The action of cis-regulatory elements with either activation or repression functions underpins the precise regulation of gene expression during normal development and cell differentiation. Gene activation by the combined activities of promoters and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f251cd5a4a94c26385ec4ca6a5de3b35
https://cnrs.hal.science/hal-04044391
https://cnrs.hal.science/hal-04044391