Zobrazeno 1 - 10
of 731
pro vyhledávání: '"Salvatore, Siena"'
Autor:
Salvatore Siena, Kanwal Raghav, Toshiki Masuishi, Kensei Yamaguchi, Tomohiro Nishina, Elena Elez, Javier Rodriguez, Ian Chau, Maria Di Bartolomeo, Hisato Kawakami, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Issey Takehara, Daniel Barrios, Kojiro Kobayashi, Axel Grothey, Takayuki Yoshino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DESTINY-CRC01 (NCT03384940) was a multicentre, open-label, phase 2 study that investigated the safety and efficacy of trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2 (HER2)-expressing metastatic color
Externí odkaz:
https://doaj.org/article/26bade50fd904d768b662d98f645dae3
Autor:
Giorgio Corti, Kristi Buzo, Enrico Berrino, Martina Miotto, Maria Costanza Aquilano, Marilena Lentini, Sara Erika Bellomo, Annalisa Lorenzato, Alice Bartolini, Gianluca Mauri, Luca Lazzari, Mariangela Russo, Federica Di Nicolantonio, Salvatore Siena, Silvia Marsoni, Caterina Marchiò, Alberto Bardelli, Sabrina Arena
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract The synthetic lethal effect observed with the use of PARP inhibitors (PARPi) with tumors characterized by the loss of key players in the homologous recombination (HR) pathway, commonly referred to as “BRCAness”, is maintaining high inter
Externí odkaz:
https://doaj.org/article/b04b94e061c24ffcaaac8ebf627bb2dd
Autor:
Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi, Raffaella Longarini, Giuseppina Arcangeli, Salvatore Corallo, Laura Delliponti, Stefano Tamberi, Elena Fea, Giovanni Brandi, Ilario Giovanni Rapposelli, Massimiliano Salati, Paolo Baili, Rosalba Miceli, Silva Ljevar, Ilaria Cavallo, Elisa Sottotetti, Antonia Martinetti, Michele Droz Dit Busset, Carlo Sposito, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud, Vincenzo Mazzaferro
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures that have a remarka
Externí odkaz:
https://doaj.org/article/90a788f11b2c4f01af1f8bfb71dabb48
Autor:
Gianluca Mauri, Giorgio Patelli, Andrea Sartore-Bianchi, Sergio Abrignani, Beatrice Bodega, Silvia Marsoni, Vincenzo Costanzo, Angela Bachi, Salvatore Siena, Alberto Bardelli
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101737- (2024)
Summary: Since the nineties, the incidence of sporadic early-onset (EO) cancers has been rising worldwide. The underlying reasons are still unknown. However, identifying them is vital for advancing both prevention and intervention. Here, we exploit a
Externí odkaz:
https://doaj.org/article/0bd42b8d24be4628affd47af60c56934
Autor:
Marco Macagno, Valeria Pessei, Noemi Congiusta, Luca Lazzari, Sara Erika Bellomo, Fariha Idrees, Alessandro Cavaliere, Filippo Pietrantonio, Alessandra Raimondi, Eleonora Gusmaroli, Maria Giulia Zampino, Lorenzo Gervaso, Davide Ciardiello, Giuseppe Mondello, Armando Santoro, Nicola Personeni, Emanuela Bonoldi, Maria Costanza Aquilano, Emanuele Valtorta, Salvatore Siena, Andrea Sartore-Bianchi, Alessio Amatu, Erica Francesca Bonazzina, Katia Bruna Bencardino, Guido Serini, Silvia Marsoni, Ludovic Barault, Federica Di Nicolantonio, Federica Maione
Publikováno v:
Diagnostics, Vol 14, Iss 22, p 2467 (2024)
Background: O-6-methylguanine-DNA methyltransferase is responsible for the direct repair of O6-methylguanine lesions induced by alkylating agents, including temozolomide. O-6-methylguanine-DNA methyltransferase promoter hypermethylation is a well-est
Externí odkaz:
https://doaj.org/article/40652073bce64bcb9e506faa61ad1641
Autor:
Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi, Rafaella Longarini, Giuseppina Arcangeli, Salvatore Corallo, Laura Delliponti, Stefano Tamberi, Elena Fea, Giovanni Brandi, Ilario Giovanni Rapposelli, Massimiliano Salati, Paolo Baili, Rosalba Miceli, Silva Ljevar, Ilaria Cavallo, Elisa Sottotetti, Antonia Martinetti, Michele Droz Dit Busset, Carlo Sposito, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud, Vincenzo Mazzaferro
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/c4ad272d3a0a4894a2606455a22c0d01
Autor:
Takayuki Yoshino, Maria Di Bartolomeo, Kanwal Raghav, Toshiki Masuishi, Fotios Loupakis, Hisato Kawakami, Kensei Yamaguchi, Tomohiro Nishina, Zev Wainberg, Elena Elez, Javier Rodriguez, Marwan Fakih, Fortunato Ciardiello, Kapil Saxena, Kojiro Kobayashi, Emarjola Bako, Yasuyuki Okuda, Gerold Meinhardt, Axel Grothey, Salvatore Siena, DESTINY-CRC01 investigators
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract DESTINY-CRC01 (NCT03384940) was a multicenter, open-label, phase 2 trial assessing the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2-expressing metastatic colorectal cancer (mCRC) that progressed after ≥2 prio
Externí odkaz:
https://doaj.org/article/b78d3fdfa83149b6a91ce6f79897ff81
Autor:
Elio Gregory Pizzutilo, MD, Alberto Giuseppe Agostara, MD, Laura Roazzi, MD, Rebecca Romanò, MD, Valentina Motta, PhD, Calogero Lauricella, PhD, Giovanna Marrapese, PhD, Giulio Cerea, MD, Diego Signorelli, MD, PhD, Silvio Marco Veronese, PhD, Laura Giuseppina Giannetta, MD, Andrea Sartore-Bianchi, MD, Salvatore Siena, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 11, Pp 100555- (2023)
ROS1 tyrosine kinase inhibitors (TKIs) were found to provide a substantial clinical benefit for patients with advanced ROS1-positive (ROS1+) NSCLC. Nevertheless, TKI resistance inevitably develops with different mechanisms, preventing prolonged respo
Externí odkaz:
https://doaj.org/article/d61ce692b70b43e5b3a2d9ee7b951f11
Autor:
Gianluca Mauri, Viviana Gori, Giorgio Patelli, Laura Roazzi, Francesco Rizzetto, Luciano De Carlis, Anna Mariani, Ugo Cavallari, Elisabetta Prada, Tiziana Cipani, Maria Costanza Aquilano, Emanuela Bonoldi, Angelo Vanzulli, Salvatore Siena, Andrea Sartore-Bianchi
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-6 (2023)
Abstract Background Cancers of the Vater ampulla (ampullary cancers, ACs) account for less than 1% of all gastrointestinal tumors. ACs are usually diagnosed at advanced stage, with poor prognosis and limited therapeutic options. BRCA2 mutations are i
Externí odkaz:
https://doaj.org/article/f683cc5011ce4ca195290f5a46e6bd1a
Autor:
Gianluca Mauri, Giorgio Patelli, Viviana Gori, Calogero Lauricella, Benedetta Mussolin, Alessio Amatu, Katia Bencardino, Federica Tosi, Erica Bonazzina, Emanuela Bonoldi, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/47b02fe9b6e54c8f96e333df60d08614