Zobrazeno 1 - 10
of 343
pro vyhledávání: '"Salvatore, Piscuoglio"'
Autor:
Michele Garioni, Viviane J. Tschan, Lauriane Blukacz, Sandro Nuciforo, Romuald Parmentier, Luca Roma, Mairene Coto-Llerena, Heike Pueschel, Salvatore Piscuoglio, Tatjana Vlajnic, Frank Stenner, Hans-Helge Seifert, Cyrill A. Rentsch, Lukas Bubendorf, Clémentine Le Magnen
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Sarcomatoid Urothelial Bladder Cancer (SARC) is a rare and aggressive histological subtype of bladder cancer for which therapeutic options are limited and experimental models are lacking. Here, we report the establishment of a long-term 3D o
Externí odkaz:
https://doaj.org/article/bcfa1bd34b2c4ad09ce019db7e34e4ca
Autor:
Kristina Handler, Karsten Bach, Costanza Borrelli, Salvatore Piscuoglio, Xenia Ficht, Ilhan E. Acar, Andreas E. Moor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cells collectively determine biological functions by communicating with each other—both through direct physical contact and secreted factors. Consequently, the local microenvironment of a cell influences its behavior, gene expression, and
Externí odkaz:
https://doaj.org/article/18203f2954534ac1a9e9ce527ec8635f
Autor:
Sumana Srivatsa, Hesam Montazeri, Gaia Bianco, Mairene Coto-Llerena, Mattia Marinucci, Charlotte K. Y. Ng, Salvatore Piscuoglio, Niko Beerenwinkel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Synthetic lethality can be used to identify potential drug targets in cancer based on simultaneous inactivation of two genes through genetic aberrations and gene silencing. Here, the authors develop a statistical framework to identify synthetic letha
Externí odkaz:
https://doaj.org/article/1e9e77d5338c4f05aac121e0023b2907
Autor:
Alexander Wilhelm, Isabelle Lemmenmeier, Alexandros Lalos, Alberto Posabella, Venkatesh Kancherla, Salvatore Piscuoglio, Tarik Delko, Markus von Flüe, Kathrin Glatz, Raoul André Droeser
Publikováno v:
BMC Endocrine Disorders, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Tumor infiltration with cytotoxic CD8+ T-cells is associated with a favorable outcome in several neoplasms, including thyroid cancer. The chemokine axis CXCR4/SDF-1 correlates with more aggressive tumors, but little is known conce
Externí odkaz:
https://doaj.org/article/ae72f38c7714428782e3079e44f9762f
Autor:
Gaetana Restivo, Aizhan Tastanova, Zsolt Balázs, Federica Panebianco, Maren Diepenbruck, Caner Ercan, Bodgan-T. Preca, Jürg Hafner, Walter P. Weber, Christian Kurzeder, Marcus Vetter, Simone Münst Soysal, Christian Beisel, Mohamed Bentires-Alj, Salvatore Piscuoglio, Michael Krauthammer, Mitchell P. Levesque
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fresh vs. slow-frozen tissues from various malignancies are compared for the establishment of 2D, 3D and ex vivo cultures, as well as for scRNAseq analysis, and found to be comparable and suitable for cancer research.
Externí odkaz:
https://doaj.org/article/87d96e9a64c244768ec47752d441b0e3
Autor:
Laia Simó-Riudalbas, Sandra Offner, Evarist Planet, Julien Duc, Laurence Abrami, Sagane Dind, Alexandre Coudray, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Claus Lindbjerg Andersen, Jesper Bertram Bramsen, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, the authors characterise cancer-specific transposable element-driven transpochimeric gene transcripts and highlight the role of POU5F1B in CRC grow
Externí odkaz:
https://doaj.org/article/a38569d1cb844be0bc2d549b4ade75f9
Autor:
Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for e
Externí odkaz:
https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75
Autor:
Cristina Quintavalle, Nathalie Meyer‐Schaller, Stephanie Roessler, Diego Calabrese, Romina Marone, Tobias Riedl, Silvia Picco‐Rey, Orestis A. Panagiotou, Sarp Uzun, Salvatore Piscuoglio, Tuyana Boldanova, Chaoran B. Bian, David Semela, Wolfram Jochum, Gieri Cathomas, Kirsten D. Mertz, Joachim Diebold, Luca Mazzucchelli, Viktor H. Koelzer, Achim Weber, Thomas Decaens, Luigi M. Terracciano, Mathias Heikenwalder, Yujin Hoshida, Jesper B. Andersen, Snorri S. Thorgeirsson, Matthias S. Matter
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1467-1481 (2022)
Chronic liver inflammation causes continuous liver damage with progressive liver fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma (HCC). Whereas the 10‐year incidence for HCC in patients with cirrhosis is approximately
Externí odkaz:
https://doaj.org/article/baec932dd7004118b6b3ef62cac7625e
Autor:
Charlotte K. Y. Ng, Eva Dazert, Tuyana Boldanova, Mairene Coto-Llerena, Sandro Nuciforo, Caner Ercan, Aleksei Suslov, Marie-Anne Meier, Thomas Bock, Alexander Schmidt, Sylvia Ketterer, Xueya Wang, Stefan Wieland, Matthias S. Matter, Marco Colombi, Salvatore Piscuoglio, Luigi M. Terracciano, Michael N. Hall, Markus H. Heim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated tumours and lacked information about the phosphoproteome. Here, the authors present a comprehensive HCC proteogenomics and phosphoproteomics study i
Externí odkaz:
https://doaj.org/article/0be87e27f0b443f98c2f8990e784ddcb
Autor:
Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples availa
Externí odkaz:
https://doaj.org/article/42966ddd44de4ed4a87861f3d4c3176c