Zobrazeno 1 - 10
of 1 070
pro vyhledávání: '"Salvage pathway"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Xanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation of th
Externí odkaz:
https://doaj.org/article/cae950f4b01347a0a5ed6c0d8b0603a4
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 1, Pp 108-114 (2024)
2′-Fucosyllactose (2′-FL) is one of the important functional oligosaccharides in breast milk. So far, few attempts on biosynthesis of 2′-FL by the salvage pathway have been reported. Herein, the salvage pathway enzyme genes were introduced into
Externí odkaz:
https://doaj.org/article/a6527b00b67c45b4a7ddc45e3052a4fd
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Halogenated organic compounds are persistent pollutants that pose a serious threat to human health and the safety of ecosystems. Cobamides are essential cofactors for reductive dehalogenases (RDase) in organohalide-respiring bacteria (OHRB), which ca
Externí odkaz:
https://doaj.org/article/e07e3da4e0e34b1cbb976f39791f8203
Autor:
Gao Yake, Dong Rui, Yan Jiacong, Chen Huicheng, Sang Lei, Yao Xinyi, Fan Die, Wang Xin, Zuo Xiaoyuan, Zhang Xu, Yang Shengyu, Wu Ze, Sun Jianwei
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 427-439 (2024)
Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development. Deoxyguanosine kinase (DGUOK) is a nucleoside kinase that salvages purine nucleosides in mitochondria and is critical for mitochondrial DNA replication and
Externí odkaz:
https://doaj.org/article/5e3d7d6d3a8c4123a0eec018d6ed8984
Autor:
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman
Publikováno v:
eLife, Vol 12 (2024)
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans. Inherited mutations that suppress HGPRT activity are associated with Lesc
Externí odkaz:
https://doaj.org/article/a6c4700cc47642c5b46c1c2efc74abf6
Autor:
Ya-Huei Chen, Wan-Hsing Cheng
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
N-Acetylglucosamine (GlcNAc), a fundamental amino sugar moiety, is essential for protein glycosylation, glycolipid, GPI-anchor protein, and cell wall components. Uridine diphosphate-GlcNAc (UDP-GlcNAc), an active form of GlcNAc, is synthesized throug
Externí odkaz:
https://doaj.org/article/692c741f4d0f4ee883cfd183768cb4a2
Autor:
Xiang-Rong Cheng, Zi-Wei Zhao, Yu-Yao Chen, Jie Song, Jia-Hui Ma, Chen-Xi Zhang, Issoufou Amadou, Nai-Yan Lu, Xue Tang, Bin Guan
Publikováno v:
Nutrients, Vol 16, Iss 15, p 2413 (2024)
Immunodeficiency can disrupt normal physiological activity and function. In this study, donkey bone collagen peptide (DP) and its iron chelate (DPI) were evaluated their potential as immunomodulators in cyclophosphamide (Cytoxan®, CTX)-induced Balb/
Externí odkaz:
https://doaj.org/article/4c3fde4977df4311bd0b177f345cade3
Publikováno v:
BMC Microbiology, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to explore the mechanisms through which microbiomes affect UA
Externí odkaz:
https://doaj.org/article/6c607fb7eba24d8b8826dbcfefa18327
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
In eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes. Purine metabolism mainly consists of de novo, salvage, and catabolic pa
Externí odkaz:
https://doaj.org/article/e389e761e2c14405874af9f04453d77d
Autor:
Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100918- (2024)
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteris
Externí odkaz:
https://doaj.org/article/2c731ca37cd542a581f44cda78d386a6