Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Salvador Mejia"'
Autor:
Shahbaz Khan, Jeffrey A. Zuccato, Vladimir Ignatchenko, Olivia Singh, Meinusha Govindarajan, Matthew Waas, Salvador Mejia-Guerrero, Andrew Gao, Gelareh Zadeh, Thomas Kislinger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Chordomas are clinically aggressive tumors with a high rate of disease progression despite maximal therapy. Given the limited therapeutic options available, there remains an urgent need for the development of novel therapies to improve clini
Externí odkaz:
https://doaj.org/article/0e0c65671c7740919f07c26c553dd04f
Autor:
Kathryn F. Cogger, Ankit Sinha, Farida Sarangi, Emily C. McGaugh, Diane Saunders, Craig Dorrell, Salvador Mejia-Guerrero, Yasaman Aghazadeh, Jillian L. Rourke, Robert A. Screaton, Markus Grompe, Philip R. Streeter, Alvin C. Powers, Marcela Brissova, Thomas Kislinger, M. Cristina Nostro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory
Externí odkaz:
https://doaj.org/article/fd9272cedfac4963a9e8b1e7fd7c10ad
Autor:
Yunee Kim, Jouhyun Jeon, Salvador Mejia, Cindy Q Yao, Vladimir Ignatchenko, Julius O Nyalwidhe, Anthony O Gramolini, Raymond S Lance, Dean A Troyer, Richard R Drake, Paul C Boutros, O. John Semmes, Thomas Kislinger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Proteomic technologies are capable of identifying thousands of proteins in biological samples, but biomarker applications are lagging. Here the authors use Multiple Reaction Monitoring Mass Spectrometry to delineate peptide signatures that accurately
Externí odkaz:
https://doaj.org/article/1db668735dc049b6843a5ba098f31c1d
Autor:
Laura Kuhlmann, Meinusha Govindarajan, Salvador Mejia-Guerrero, Vladimir Ignatchenko, Lydia Y. Liu, Barbara T. Grünwald, Jennifer Cruickshank, Hal Berman, Rama Khokha, Thomas Kislinger
Publikováno v:
Journal of proteome research. 21(9)
Driven by the lack of targeted therapies, triple-negative breast cancers (TNBCs) have the worst overall survival of all breast cancer subtypes. Considering that cell surface proteins are favorable drug targets and are predominantly glycosylated, glyc
Autor:
Paula R. Quaglietta, Ashby Kissoondoyal, Ethan Malkin, Salvador Mejia, Ann Gong, David Malkin, Reto M. Baertschiger
Publikováno v:
Cancer Research. 83:5309-5309
Extracellular vesicles (EVs) are nano-sized (30-1000 nm) membranous particles released by nearly all cell types. EV biology is a rapidly growing field, however its relative novelty and the intrinsic heterogeneity of EVs result in a lack of standardiz
Autor:
Salvador Mejia-Guerrero, Thomas Kislinger, Vladimir Ignatchenko, Lydia Y Liu, Meinusha Govindarajan, Ankit Sinha, Andrew Macklin, Jennifer Cruickshank, Hal K. Berman, Amanda Khoo, Laura Kuhlmann
Publikováno v:
Cancer Research. 81:PS18-31
Triple negative breast cancer (TNBC) stands out due to its aggressive course and high metastatic rates. No consistent protein biomarker has been described for TNBC, resulting in a scarcity of adjuvant therapies for the afflicted patients. Hence, ther
Autor:
Mariana Morales-Quinones, Zachary I. Grunewald, Jaume Padilla, Salvador Mejia, Camila Manrique-Acevedo, Bysani Chandrasekar, Luis A. Martinez-Lemus, Makenzie L Woodford, Ulrich Siebenlist, Francisco I. Ramirez-Perez
Publikováno v:
Hypertension. 76:1319-1329
Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to the pathogenesis of vascular dysfunction and disease. However, the molecular mechanisms underlying obesity-associated vascular insulin resistance and dysf
Autor:
Thomas Kislinger, Ankit Sinha, W. Shi, Laurie Ailles, David P. Goldstein, Susie Su, Fei-Fei Liu, Simona Principe, Wei Xu, Alexandr Ignatchenko, Vladimir Ignatchenko, Salvador Mejia-Guerrero, Ilan Weinreb, Keira Pereira, Shao Hui Huang, Brian O'Sullivan
Publikováno v:
Journal of Proteome Research. 17:2045-2059
Bidirectional communication between cells and their microenvironment is crucial for both normal tissue homeostasis and tumor growth. During the development of oral tongue squamous cell carcinoma (OTSCC), cancer-associated fibroblasts (CAFs) create a
Autor:
Vladimir Ignatchenko, Ankit Sinha, Thomas Kislinger, Alex Ignatchenko, Salvador Mejia-Guerrero
Publikováno v:
Biochemical and Biophysical Research Communications. 445:694-701
Molecular communication between cancer cells and its stromal microenvironment is a key factor for cancer progression. Alongside classic secretory pathways, it has recently been proposed that small membranous vesicles are alternative mediators of inte
Autor:
Ren-Ke Li, Yuemei Zhang, Zhuo Sun, Koji Higuchi, Jeffrey A. Medin, Chyan-Jang Lee, Salvador Mejia-Guerrero
Publikováno v:
Human Gene Therapy. 23:1280-1289
Stem cell mobilization to injured tissue contributes to neovascularization, resulting in regeneration after myocardial infarction (MI). We previously showed that direct cardiac injection of a recombinant lentivirus (LV) that engineers expression of m