Of mitochondrion and COVID-19

Autor: Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1258-1266 (2021)

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefo

Externí odkaz: https://doaj.org/article/993454466004434cb52a3371c266e824

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

Autor: Khalid O. Alfarouk, Samrein B. M. Ahmed, Robert L. Elliott, Amanda Benoit, Saad S. Alqahtani, Muntaser E. Ibrahim, Adil H. H. Bashir, Sari T. S. Alhoufie, Gamal O. Elhassan, Christian C. Wales, Laurent H. Schwartz, Heyam S. Ali, Ahmed Ahmed, Patrick F. Forde, Jesus Devesa, Rosa A. Cardone, Stefano Fais, Salvador Harguindey, Stephan J. Reshkin

Publikováno v: Metabolites, Vol 10, Iss 7, p 285 (2020)

The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of

Externí odkaz: https://doaj.org/article/97aae85c7d4744afaf11a9c2481043d5

Of mitochondrion and COVID-19

Autor: Abdel Khalig Muddathir, Saad S. Alqahtani, Rosa Angela Cardone, Sari T S Alhoufie, Samrein B M Ahmed, Ali Alqahtani, Salvador Harguindey, Abdelhameed Hifny, Laurent Schwartz, Adil H. H. Bashir, Maria Raffaella Greco, Muntaser E. Ibrahim, Khalid O. Alfarouk, Ali S Alqahtani, Heyam Saad Ali, Stephan J. Reshkin

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1258-1266 (2021)

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51056456544ffc01513e495bbc0aaa75
https://doi.org/10.1080/14756366.2021.1937144

The Prime and Integral Cause of Cancer in the Post-Warburg Era

Autor: Salvador Harguindey, Khalid Omer Alfarouk, Stephan Reshkin

Publikováno v: Cancers. 15:540

Back to beginnings. A century ago, Otto Warburg published that aerobic glycolysis and the respiratory impairment of cells were the prime cause of cancer, a phenomenon that since then has been known as “the Warburg effect”. In his early studies, W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d124d3ff87ca81d7ec7a946893d6f4e0
https://doi.org/10.3390/cancers15020540

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H

Autor: Salvador, Harguindey, Khalid, Alfarouk, Julián, Polo Orozco, Stefano, Fais, Jesús, Devesa

Publikováno v: International Journal of Molecular Sciences

A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7681afa16c946a2bca7e992da471c3f
https://pubmed.ncbi.nlm.nih.gov/33050492