The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Autor: Khalid O. Alfarouk, Adil H. H. Bashir, Ahmed N. Aljarbou, AbdelRahman M. Ramadan, Abdel Khalig Muddathir, Sari T. S. AlHoufie, Abdelhamid Hifny, Gamal O. Elhassan, Muntaser E. Ibrahim, Saad S. Alqahtani, Shakir D. AlSharari, Claudiu T. Supuran, Cyril Rauch, Rosa Angela Cardone, Stephan J. Reshkin, Stefano Fais, Salvador Harguindey

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related fac

Externí odkaz: https://doaj.org/article/f3ef486877ef40e1a499eb3a9b230f0b

Of mitochondrion and COVID-19

Autor: Abdel Khalig Muddathir, Saad S. Alqahtani, Rosa Angela Cardone, Sari T S Alhoufie, Samrein B M Ahmed, Ali Alqahtani, Salvador Harguindey, Abdelhameed Hifny, Laurent Schwartz, Adil H. H. Bashir, Maria Raffaella Greco, Muntaser E. Ibrahim, Khalid O. Alfarouk, Ali S Alqahtani, Heyam Saad Ali, Stephan J. Reshkin

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1258-1266 (2021)

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51056456544ffc01513e495bbc0aaa75
https://doi.org/10.1080/14756366.2021.1937144

The Prime and Integral Cause of Cancer in the Post-Warburg Era

Autor: Salvador Harguindey, Khalid Omer Alfarouk, Stephan Reshkin

Publikováno v: Cancers. 15:540

Back to beginnings. A century ago, Otto Warburg published that aerobic glycolysis and the respiratory impairment of cells were the prime cause of cancer, a phenomenon that since then has been known as “the Warburg effect”. In his early studies, W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d124d3ff87ca81d7ec7a946893d6f4e0
https://doi.org/10.3390/cancers15020540

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Autor: Salvador Harguindey, Jesús Devesa, Stefano Fais, Khalid O. Alfarouk, Julián Polo Orozco

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7475, p 7475 (2020)

A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929ac1c15dd055ab7939f68bca76cdcc

The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer

Autor: Sari T S Alhoufie, Heyam Saad Ali, Ahmed N. Aljarbou, Christian C. Wales, Ibrahim Nourwali, Robert L. Elliott, Ahmed Qasim Ahmed, Samrein B M Ahmed, Muntaser E. Ibrahim, Saad S. Alqahtani, Stephan J. Reshkin, Khalid O. Alfarouk, Salvador Harguindey, Rosa Angela Cardone, Stefano Fais, Adil H. H. Bashir

Publikováno v: Cancers, Vol 12, Iss 898, p 898 (2020)
Cancers

Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons through fermentative glycolysis. This leads to extracellular acidosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8eacb174a3e5012f9b3f18b1e16d7e
https://www.mdpi.com/2072-6694/12/4/898