Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Salowe SP"'
2
Akademický článek
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Autor: Petrilli WL; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: whitney_petrilli@merck.com., Adam GC; Pharmacology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address: gregory_adam@merck.com., Erdmann RS; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA; Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: roman.erdmann@merck.com., Abeywickrema P; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Agnani V; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Ai X; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Baysarowich J; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Byrne N; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Caldwell JP; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Chang W; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., DiNunzio E; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Feng Z; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Ford R; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Ha S; Computational and Structural Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Huang Y; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Hubbard B; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Johnston JM; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Kavana M; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lisnock JM; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Liang R; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lu J; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Lu Z; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Meng J; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Orth P; Computational and Structural Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Palyha O; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Parthasarathy G; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Salowe SP; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Sharma S; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Shipman J; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Soisson SM; Computational and Structural Chemistry, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Strack AM; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Youm H; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zhao K; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zink DL; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zokian H; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Addona GH; In Vitro Pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Akinsanya K; Cardio Metabolic Diseases, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Tata JR; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Xiong Y; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Imbriglio JE; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Publikováno v: Cell chemical biology [Cell Chem Biol] 2020 Jan 16; Vol. 27 (1), pp. 32-40.e3. Date of Electronic Publication: 2019 Oct 22.
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3
Akademický článek
Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
Autor: Debenham JS; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Madsen-Duggan C; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Clements MJ; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Walsh TF; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Kuethe JT; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Reibarkh M; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Salowe SP; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Sonatore LM; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Hajdu R; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Milligan JA; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Visco DM; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Zhou D; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Lingham RB; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Stickens D; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., DeMartino JA; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Tong X; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Wolff M; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Pang J; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Miller RR; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Sherer EC; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States., Hale JJ; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 22; Vol. 59 (24), pp. 11039-11049. Date of Electronic Publication: 2016 Nov 30.
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4
Akademický článek
In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors.
Autor: Salowe SP; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Zhang L; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Zokian HJ; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Gesell JJ; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA.; 2 Current address: Janssen Research & Development LLC, Spring House, PA, USA., Zink DL; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Wiltsie J; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Ai X; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Kavana M; 1 Department of In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA., Pinto S; 3 Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ, USA.
Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2016 Dec; Vol. 21 (10), pp. 1034-1041. Date of Electronic Publication: 2016 Jul 11.
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5
Akademický článek
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
Autor: Vachal P; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA. petr_vachal@merck.com, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R, Gollapudi A, Keohane CA, Lingham RB, Mandala SM, DeMartino JA, Tong X, Wolff M, Steinhuebel D, Kieczykowski GR, Fleitz FJ, Chapman K, Athanasopoulos J, Adam G, Akyuz CD, Jena DK, Lusen JW, Meng J, Stein BD, Xia L, Sherer EC, Hale JJ
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 2945-59. Date of Electronic Publication: 2012 Feb 27.
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6
Akademický článek
Disubstituted pyrimidines as Lck inhibitors.
Autor: Hunt JA; Merck Research Laboratories, Merck & Co., PO Box 2000, Rahway, NJ 07065, United States. julianne_hunt@merck.com, Beresis RT, Goulet JL, Holmes MA, Hong XJ, Kovacs E, Mills SG, Ruzek RD, Wong F, Hermes JD, Park YW, Salowe SP, Sonatore LM, Wu L, Woods A, Zaller DM, Sinclair PJ
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Sep 15; Vol. 19 (18), pp. 5440-3. Date of Electronic Publication: 2009 Jul 25.
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7
Akademický článek
The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase.
Autor: Salowe SP; Department of Infectious Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA. scott_salowe@merck.com, Wiltsie J, Hawkins JC, Sonatore LM
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2009 Apr 10; Vol. 284 (15), pp. 9656-62. Date of Electronic Publication: 2009 Feb 19.
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8
Akademický článek
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Autor: Xiong Y; Merck Research laboratories, Rahway, NJ 07065, USA. yusheng.xiong@merck.com, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Feb 15; Vol. 16 (4), pp. 964-8. Date of Electronic Publication: 2005 Dec 09.
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9
Akademický článek
Anthrax lethal factor inhibition.
Autor: Shoop WL; Merck Research Laboratories, Rahway, NJ 07065, USA. weseley_shoop@merck.com, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Felcetto T, Michael BF, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Patel SB, Wisniewski D, Scapin G, Salowe SP, Zaller DM, Chapman KT, Scolnick EM, Schmatz DM, Bartizal K, MacCoss M, Hermes JD
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 May 31; Vol. 102 (22), pp. 7958-63. Date of Electronic Publication: 2005 May 23.
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10
Akademický článek
Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.
Autor: Donald RG; Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Merck and Co., Inc., Rahway New Jersey 07065, USA. robert_donald@merck.com, Allocco J, Singh SB, Nare B, Salowe SP, Wiltsie J, Liberator PA
Publikováno v: Eukaryotic cell [Eukaryot Cell] 2002 Jun; Vol. 1 (3), pp. 317-28.
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