Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate.

Autor: Linetsky M; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106.; Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106., Mondal A; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Liu SY; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Hite AM; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Enduri S; Department of Biology, Case Western Reserve University, Cleveland, OH 44106., Cheng YS; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Feijo B; Department of Biology, Case Western Reserve University, Cleveland, OH 44106., Kang G; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Arhin N; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106., Zeng H; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Laniak OR; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106., Denker J; Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106., Salomon RG; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106.; Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106.

Publikováno v: Results in chemistry [Results Chem] 2023 Dec; Vol. 6. Date of Electronic Publication: 2023 Jun 11.

4-Hydroxy-7-oxo-5-heptenoic acid lactone can induce mitochondrial dysfunction in retinal pigmented epithelial cells.

Autor: Cheng YS; Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA., Linetsky M; Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Li H; Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA., Ayyash N; Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA., Gardella A; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Salomon RG; Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: rgs@case.edu.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2020 Nov 20; Vol. 160, pp. 719-733. Date of Electronic Publication: 2020 Sep 10.

Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.

Autor: Mulfaul K; Department Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland., Ozaki E; Department Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland., Fernando N; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Brennan K; Department Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland., Chirco KR; Institute for Vision Research, University of Iowa, Iowa City, IA, USA., Connolly E; Department Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland., Greene C; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Maminishkis A; National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Salomon RG; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA., Linetsky M; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA., Natoli R; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia; The ANU Medical School, The Australian National University, Canberra, ACT, Australia., Mullins RF; Institute for Vision Research, University of Iowa, Iowa City, IA, USA., Campbell M; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doyle SL; Department Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience (TCIN), TCD, Dublin 2, Ireland; The National Children's Research Centre, Our Lady's Hospital Crumlin, Dublin 12, Ireland. Electronic address: sarah.doyle@tcd.ie.

Publikováno v: Cell reports [Cell Rep] 2020 Feb 18; Vol. 30 (7), pp. 2209-2224.e5.

Platelet-enriched microRNAs as novel biomarkers in atherosclerotic and cardiovascular disease patients.

Autor: Masoudikabir, Parisa¹, Shirazy, Mohammadreza¹, Taghizadeh, Fatemeh Sigarchian², Gheydari, Mohamad Esmail³, Hamidpour, Mohsen⁴ mohsenhp@sbmu.ac.ir

Publikováno v: ARYA Atherosclerosis. Jul/Aug2024, Vol. 20 Issue 4, p47-67. 21p.

The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole⁻Pyrrole Crosslinks and Lactams.

Autor: Bi W; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. wxb96@case.edu., Jang GF; Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. jangg@ccf.org., Zhang L; Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. zhangl@ccf.rg., Crabb JW; Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. crabbj@ccf.org., Laird J; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. jxl122@case.edu., Linetsky M; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. mdl78@case.edu., Salomon RG; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. rgs@case.edu.

Publikováno v: High-throughput [High Throughput] 2019 May 10; Vol. 8 (2). Date of Electronic Publication: 2019 May 10.