Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Salome V. Ibba"'
1
Akademický článek
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
Autor: Mohamed A. Ghonim, Jihang Ju, Kusma Pyakurel, Salome V. Ibba, Mai M. Abouzeid, Hamada F. Rady, Shigemi Matsuyama, Luis Del Valle, A. Hamid Boulares
Publikováno v: Journal of Inflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is established, but its rol
Externí odkaz: https://doaj.org/article/ab21f508a8dd4a0da29878d32d70148d
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2
Akademický článek
Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy
Autor: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the
Externí odkaz: https://doaj.org/article/06e8d087c8bf469fa6f8d3b011c19b21
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3
Akademický článek
Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses
Autor: Giulia Monticone, Zhi Huang, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Keli Xu, Samarpan Majumder, Barbara A. Osborne, Christine Loh, Lucio Miele
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
A critical feature of cancer is the ability to induce immunosuppression and evade immune responses. Tumor-induced immunosuppression diminishes the effectiveness of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In thi
Externí odkaz: https://doaj.org/article/f8e940e37817407f8336c28c349fbf51
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4
Akademický článek
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway
Autor: Mohamed A. Ghonim, Jeffrey Wang, Salome V. Ibba, Hanh H. Luu, Kusma Pyakurel, Ilyes Benslimane, Shaker Mousa, A. Hamid Boulares
Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put in
Externí odkaz: https://doaj.org/article/9f367d95146e4c9fafcc7be9fc3fbb45
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6
Abstract 4211: Minocycline-based metronomic therapy as a novel approach to enhance anti-tumor immune responses and reduce tumor burden in mouse models of colorectal cancer
Autor: Salome V. Ibba, Hanh H. Luu, Mohamed Ghonim, Cecilia Vittori, Matthew J. Dean, Giulia Monticone, Francesca Peruzzi, Augusto Ochoa, Lucio Miele, Hamid A. Boulares
Publikováno v: Cancer Research. 82:4211-4211
Despite the availability of numerous new therapies including immune checkpoint inhibitors, patients with colon cancer are faced with limited treatment options. We recently demonstrated that low metronomic dose of PARP inhibitor synergizes with anti-P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8dc9bdfdf759a5633c8caf257d07ae6
https://doi.org/10.1158/1538-7445.am2022-4211
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7
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway
Autor: Ilyes Benslimane, Mohamed A. Ghonim, A. Hamid Boulares, Hanh H Luu, Shaker A. Mousa, Jeffrey Wang, Salome V. Ibba, Kusma Pyakurel
Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Journal of Translational Medicine
Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put into harnes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf48aa3f6f1e50b94a2e0f4ac001136
http://link.springer.com/article/10.1186/s12967-018-1621-5
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8
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer
Autor: Augusto C. Ochoa, A. Hamid Boulares, Mohamed A. Ghonim, Luis Del Valle, Abdelmetalab Tarhuni, Amir A. Al-Khami, Dorota Wyczechowska, Ilyes Benslimane, Ali H. El-Bahrawy, Hanh H Luu, Matthew Dean, Salome V. Ibba, Youssef Errami
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
BackgroundPoly(ADP-ribose) polymerase (PARP) inhibitors (eg, olaparib) are effective against BRCA-mutated cancers at/near maximum tolerated doses by trapping PARP-1 on damaged chromatin, benefitting only small patient proportions. The benefits of tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7e33fb8bd0a0754e0ae9e654343c2b
https://doi.org/10.1136/jitc-2020-001643
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