Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Salman Y. Jabri"'
Autor:
Salman Y. Jabri, Larry E. Overman
Publikováno v:
The Journal of Organic Chemistry. 78:8766-8788
Evolution of the synthetic strategy that culminated in the first total syntheses of the structurally unique plectosphaeroic acids B (2) and C (3) is described. The successful enantioselective route to (+)-2 and (+)-3 proceeds in 6 and 11 steps from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60270d799f2c026a4d38218c1035f545
https://doi.org/10.1021/jo4015479
https://doi.org/10.1021/jo4015479
Autor:
Choung U. Kim, Sammy Metobo, Haolun Jin, Salman Y. Jabri, Jared W. Evans, Evangelos Aktoudianakis
Publikováno v:
Tetrahedron Letters. 54:6782-6784
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)-nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fd3b524da37dbff47de62bffb20c444
https://doi.org/10.1016/j.tetlet.2013.10.020
https://doi.org/10.1016/j.tetlet.2013.10.020
Autor:
Manuel Tsiang, Matthew R. Wright, Choung U. Kim, Salman Y. Jabri, Sammy Metobo, Haolun Jin, Xiaowu Chen, Mish Michael R, Rachael A. Lansdown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1187-1190
A series of C3 halobenzyl-substituted tricyclic HIV integrase inhibitors was prepared. Improvement in cell-based inhibitor potency was observed in comparison to previously disclosed tricyclic pyrroloquinolines carrying the ‘halobenzyl tail’ at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aab536bd1fb1b3651b5924978573b1
https://doi.org/10.1016/j.bmcl.2008.12.079
https://doi.org/10.1016/j.bmcl.2008.12.079
Autor:
Choung U. Kim, Richard W. Pastor, Matthew R. Wright, Haolun Jin, Salman Y. Jabri, Peter Pyun, Sammy Metobo, Rachael A. Lansdown, Manuel Tsiang, Ruby Cai, Xiaowu Chen, Mish Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1388-1391
A series of C5-aza tricyclic HIV integrase inhibitors was prepared. A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ece5ac258a10ac3035a295370face10
https://doi.org/10.1016/j.bmcl.2008.01.018
https://doi.org/10.1016/j.bmcl.2008.01.018
Autor:
Jared W. Evans, Choung U. Kim, Evangelos Aktoudianakis, Haolun Jin, Salman Y. Jabri, Sammy Metobo
Publikováno v:
ChemInform. 45
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)-nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2007a22ac8b873b6417a0518469cb1c
https://doi.org/10.1002/chin.201417039
https://doi.org/10.1002/chin.201417039
Autor:
Larry E. Overman, Salman Y. Jabri
Publikováno v:
ChemInform. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abd56db943d5e559f67fafdeb7b7b30
https://doi.org/10.1002/chin.201406223
https://doi.org/10.1002/chin.201406223
A concise second-generation total synthesis of the fungal-derived alkaloid (+)-gliocladin C (11) in 10 steps and 11% overall yield from isatin is reported. In addition, the epipolythiodioxopiperazine (ETP) natural product (+)-gliocladine C (6) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad2b436a06f0cfc98f77f53cc05937a
https://europepmc.org/articles/PMC3090078/
https://europepmc.org/articles/PMC3090078/
Autor:
Xiaowu Chen, Choung U. Kim, Haolun Jin, Manuel Tsiang, Sammy Metobo, Matthew R. Wright, Rachael A. Lansdown, Mish Michael R, Salman Y. Jabri
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(8)
SAR studies on the para-fluorobenzyl moiety of tricyclic HIV integrase inhibitors are discussed and lead compounds with potency and PK properties comparable to raltegravir were identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426ca52f661686de89f7fdba233e4b57
https://pubmed.ncbi.nlm.nih.gov/19285389
https://pubmed.ncbi.nlm.nih.gov/19285389
Autor:
Schacherer Laura N, Choung U. Kim, Maria Fardis, Ruby Cai, Haolun Jin, James M. Chen, Manuel Tsiang, Xiaowu Chen, Salman Y. Jabri
Publikováno v:
ChemInform. 37
A novel class of tri-cyclic HIV integrase inhibitors were designed based on conformational analysis of 1,6-naphthyridine carboxamide compound L-870810 and docking the designed inhibitor into the active site of our integrase enzyme model. The efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebf617ac156d7d07c3b967d9f3556be
https://doi.org/10.1002/chin.200646188
https://doi.org/10.1002/chin.200646188
Autor:
Choung U. Kim, Maria Fardis, Mish Michael R, Ruby Cai, Manuel Tsiang, Haolun Jin, Salman Y. Jabri
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
A series of novel tricyclic inhibitors of HIV-1 integrase enzyme was prepared. The effect of substitution at C-6 of the 9-hydroxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one compounds was studied in vitro. Inhibitors with small side chains at C-6 were ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c192d7119a37c3e5fbab9c0c84446b2a
https://pubmed.ncbi.nlm.nih.gov/16716589
https://pubmed.ncbi.nlm.nih.gov/16716589