Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Salman R. Khetani"'
Autor:
Xinghang Jiang, Olivia T. Ly, Hanna Chen, Ziwei Zhang, Beatriz A. Ibarra, Mahmud A. Pavel, Grace E. Brown, Arvind Sridhar, David Tofovic, Abigail Swick, Richard Marszalek, Carlos G. Vanoye, Fritz Navales, Alfred L. George, Jr., Salman R. Khetani, Jalees Rehman, Yu Gao, Dawood Darbar, Ankur Saxena
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110395- (2024)
Summary: Developmental causes of the most common arrhythmia, atrial fibrillation (AF), are poorly defined, with compensation potentially masking arrhythmic risk. Here, we delete 9 amino acids (Δ9) within a conserved domain of the giant protein titin
Externí odkaz:
https://doaj.org/article/489be31f1fb44db7b69aaaf61e69c5c9
Autor:
Jui-Tung Liu, Caren Doueiry, Yu-lin Jiang, Josef Blaszkiewicz, Mary Paige Lamprecht, James A. Heslop, Yuri K. Peterson, Juliana Debrito Carten, Paula Traktman, Yang Yuan, Salman R. Khetani, Waleed O. Twal, Stephen A. Duncan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which can cause severe cardiovascular disease. Statins, bile acid sequestrants, PCSK9 inhibitors, and cholesterol
Externí odkaz:
https://doaj.org/article/fe36e9c4a8724c3384dc661b32a9f5f8
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 5, Pp 1147-1160 (2023)
Several liver diseases (eg, hepatitis B/C viruses, alcoholic/nonalcoholic fatty liver, malaria, monogenic diseases, and drug-induced liver injury) significantly impact global mortality and morbidity. Species-specific differences in liver functions li
Externí odkaz:
https://doaj.org/article/ebd5c47044a2442d93a086723d419cd6
Autor:
Aidan Brougham-Cook, Hannah R. C. Kimmel, Chase P. Monckton, Daniel Owen, Salman R. Khetani, Gregory H. Underhill
Publikováno v:
APL Bioengineering, Vol 6, Iss 4, Pp 046102-046102-16 (2022)
Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant wound healing. Changes in the composition of the liver microenvironment during fibrosis result in a complex crosstalk of extracellular cues that promote altered
Externí odkaz:
https://doaj.org/article/d46964232c6a4c329ffef72ed492def0
Autor:
Olivia T. Ly, Hanna Chen, Grace E. Brown, Liang Hong, Xinge Wang, Yong Duk Han, Mahmud Arif Pavel, Arvind Sridhar, Mark Maienschein-Cline, Brandon Chalazan, Sang-Ging Ong, Khaled Abdelhady, Malek Massad, Lona Ernst Rizkallah, Jalees Rehman, Salman R. Khetani, Dawood Darbar
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) can model heritable arrhythmias to personalize therapies for individual patients. Although atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality,
Externí odkaz:
https://doaj.org/article/2cbefd4c83254f4fb0d6f8d93e7817d4
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 031506-031506-17 (2021)
Drug-induced liver injury (DILI) is a leading cause of drug attrition, which is partly due to differences between preclinical animals and humans in metabolic pathways. Therefore, in vitro human liver models are utilized in biopharmaceutical practice
Externí odkaz:
https://doaj.org/article/29bbb9b6946e43d7b5e9253b38136a9a
Autor:
Reshmii Venkatesan, Mohamed Ali Hussein, Leah Moses, Jennifer S. Liu, Salman R. Khetani, Alexander Kornienko, Gnanasekar Munirathinam
Publikováno v:
Cancers, Vol 14, Iss 21, p 5260 (2022)
Prostate cancer (PCa) is the second leading cause of cancer death among men in the United States. Surgery, radiation therapy, chemotherapy, and androgen deprivation therapy are currently the standard treatment options for PCa. These have poor outcome
Externí odkaz:
https://doaj.org/article/ab5c5ccc99544269af49de407f09c88c
Publikováno v:
APL Bioengineering, Vol 3, Iss 4, Pp 040902-040902-14 (2019)
The liver executes 500+ functions, such as protein synthesis, xenobiotic metabolism, bile production, and metabolism of carbohydrates/fats/proteins. Such functions can be severely degraded by drug-induced liver injury, nonalcoholic fatty liver diseas
Externí odkaz:
https://doaj.org/article/1b4bfb15e70041dcac670a91e0912eda
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 187-207 (2018)
Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) in vitro can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however, existin
Externí odkaz:
https://doaj.org/article/96fde98f579a4ae780eadd6fbbee0bdc
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 426-439.e1 (2018)
In vitro models of the human liver are important for the following: (1) mitigating the risk of drug-induced liver injury to human beings, (2) modeling human liver diseases, (3) elucidating the role of single and combinatorial microenvironmental cues
Externí odkaz:
https://doaj.org/article/2e8e23dd6f5a439e8f917dca6a311ef2