Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Salmaan A. Khan"'
Autor:
Ian A. MacNeil, Salmaan A. Khan, Adrish Sen, Sajjad M. Soltani, David J. Burns, Brian F. Sullivan, Lance G. Laing
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Research is revealing the complex coordination between cell signaling systems as they adapt to genetic and epigenetic changes. Tools to uncover these highly complex functional linkages will play an important role in advancing more
Externí odkaz:
https://doaj.org/article/139007276e3a4bb0a503fc7b6a73d213
Autor:
Wenwei Zhang, So Young Bu, Mara T. Mashek, InSug O-Sullivan, Zakaria Sibai, Salmaan A. Khan, Olga Ilkayeva, Christopher B. Newgard, Douglas G. Mashek, Terry G. Unterman
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 349-359 (2016)
Metabolism is a highly integrated process that is coordinately regulated between tissues and within individual cells. FoxO proteins are major targets of insulin action and contribute to the regulation of gluconeogenesis, glycolysis, and lipogenesis i
Externí odkaz:
https://doaj.org/article/8bf2196c73814cc4832bcb7e2543ed04
Autor:
Adrish Sen, Salmaan A Khan, Ian A. MacNeil, Benjamin E. Rich, Jhomary S Molden, Laura N Davis, Stefano Rossetti, Aaron M Broege, Lance G. Laing
Publikováno v:
Journal of Clinical Oncology. 41:149-149
149 Background: Metastatic castration-resistant prostate cancer (mCRPrC) is characterized by a loss of androgen receptor (AR) sensitivity and oncogenic activation of the PI3K, AKT, and mTOR (PAM) pathway. Loss of the PI3K regulator, PTEN, is frequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95c4a818acf08c742670a5d2a816f40
https://doi.org/10.1200/jco.2023.41.6_suppl.149
https://doi.org/10.1200/jco.2023.41.6_suppl.149
Autor:
Ian A. MacNeil, Salmaan A. Khan, Adrish Sen, Sajjad M. Soltani, David J. Burns, Brian F. Sullivan, Lance G. Laing
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)
Background Research is revealing the complex coordination between cell signaling systems as they adapt to genetic and epigenetic changes. Tools to uncover these highly complex functional linkages will play an important role in advancing more efficaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7be033de41d53792a7b57a06067b14
https://pubmed.ncbi.nlm.nih.gov/34998412
https://pubmed.ncbi.nlm.nih.gov/34998412
Autor:
So Young Bu, In Sug O-Sullivan, Salmaan A. Khan, Wenwei Zhang, Douglas G. Mashek, Zakaria Sibai, Christopher B. Newgard, Terry G. Unterman, Olga Ilkayeva, Mara T. Mashek
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 349-359 (2016)
FoxO proteins are major targets of insulin action. Adipose triacylglycerol (TAG) lipase mediates the first step in TAG hydrolysis and FoxO1 stimulates ATGL expression in adipose tissue. Here, we report that FoxO1 also stimulates ATGL and suppresses e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4fa31d7a6848287a8438eb04f67fc4
https://doi.org/10.1016/j.celrep.2016.03.021
https://doi.org/10.1016/j.celrep.2016.03.021
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
Autor:
Mallory P. Franklin, Mark J. Graham, Linnea E. Mead, Timothy D. Heden, Kenneth K. Karanja, Bruce A. Witthuhn, Laurie L. Parker, Charles P. Najt, Douglas G. Mashek, Lisa S. Chow, Minervo Perez, Mara T. Mashek, Jason L. Heier, Salmaan A. Khan, David A. Bernlohr
Publikováno v:
Mol Cell
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e63a41d9d608077141054c95b07a0ce
https://doi.org/10.1016/j.molcel.2019.12.003
https://doi.org/10.1016/j.molcel.2019.12.003
Autor:
Douglas G. Mashek, LeeAnn Higgins, Edith E. Wollaston-Hayden, Salmaan A. Khan, Todd W. Markowski
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2260-2272 (2015)
Hepatic steatosis is characterized by the accumulation of lipid droplets (LDs), which are composed of a neutral lipid core surrounded by a phospholipid monolayer embedded with many proteins. Although the LD-associated proteome has been investigated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c486111b03e6d942d445046ee8cc9
http://www.sciencedirect.com/science/article/pii/S0022227520309469
http://www.sciencedirect.com/science/article/pii/S0022227520309469
Autor:
Mallory P. Franklin, Douglas G. Mashek, Jonathan M. Ploeger, Aishwarya Sathyanarayan, Salmaan A. Khan
Publikováno v:
Hepatology. 62:964-967
Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9037350294bb7bf385d55df2b2ec51b7
https://doi.org/10.1002/hep.27839
https://doi.org/10.1002/hep.27839
Autor:
Edith E. Wollaston-Hayden, Salmaan A. Khan, Aishwarya Sathyanarayan, Douglas G. Mashek, Kuok Teong Ong, Mara T. Mashek
Publikováno v:
Diabetes
Sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase, regulates a host of target proteins, including peroxisome proliferator–activated receptor (PPAR)-γ coactivator-1α (PGC-1α), a transcriptional coregulator that binds to numerous transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7ac74179f753c6cdc4f407303f7bac
http://europepmc.org/articles/PMC4303962
http://europepmc.org/articles/PMC4303962
Publikováno v:
Trends in Biotechnology. 28:476-484
Cultured mammalian cells are major vehicles for producing therapeutic proteins, and energy metabolism in those cells profoundly affects process productivity. The characteristic high glucose consumption and lactate production of industrial cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72bef1c4f563ff6050746a57ad98a27
https://doi.org/10.1016/j.tibtech.2010.06.005
https://doi.org/10.1016/j.tibtech.2010.06.005