Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sally V, Watt"'
Autor:
Vivien R. Sutton, Sally V. Watt, Hedieh Akhlaghi, David C. Cipolla, Kuan-Ju Chen, Daniel LaSala, Patrick P. McDonald, Paul A. Beavis, Isabelle Munoz, Adrian W. Hodel, Tahereh Noori, Ilia Voskoboinik, Joseph A. Trapani
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of neutrophil s
Externí odkaz:
https://doaj.org/article/637ceae3f9ef4a27add5a0ac7f8e1bc1
Autor:
Joseph A. Trapani, Vivien R. Sutton, Annette Ciccone, Sandra Verschoor, Michael G. Leeming, Mariapia A. Degli-Esposti, Colin M. House, Sally V. Watt, Christopher E. Andoniou, Ilia Voskoboinik
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(9)
We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the pro-apoptotic serine protease granzyme B to mouse cytomegalovirus infection. Whereas C57BL/6 mice homozygous for granzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a5cc4a30420da754bfbf59d48439c
https://pubmed.ncbi.nlm.nih.gov/32473350
https://pubmed.ncbi.nlm.nih.gov/32473350
Publikováno v:
Immunological Reviews. 235:73-92
Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected with intracellular pathogens. One mechanism, known as granule exocytosis, employs the secretory granules of these lymphocytes. These include the pore-forming pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942f762dd6795f29de5ce46bdc35c9e4
https://doi.org/10.1111/j.0105-2896.2010.00907.x
https://doi.org/10.1111/j.0105-2896.2010.00907.x
Autor:
Mandy J. Ludford-Menting, Christopher J.P. Clarke, Ricky W. Johnstone, Ze’ev Bomzon, Jane Oliaro, Sally V. Watt, Steven L. Reiner, Michael Bots, Min Gu, David J. Izon, Patrick O. Humbert, Leonie A. Cluse, Faruk Sacirbegovic, Nigel J. Waterhouse, Sarah M. Russell, Natalie Thompson, Kim Pham, John T. Chang, Anupama Pasam, Edwin D. Hawkins, Mark J. Smyth, Vanessa Van Ham
Publikováno v:
Journal of immunology (Baltimore, Md., 185(1), 367-375. American Association of Immunologists
Asymmetric cell division is a potential means by which cell fate choices during an immune response are orchestrated. Defining the molecular mechanisms that underlie asymmetric division of T cells is paramount for determining the role of this process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd23aea53cbd1359acf2c1d3824c004
https://doi.org/10.4049/jimmunol.0903627
https://doi.org/10.4049/jimmunol.0903627
Publikováno v:
The Journal of Immunology. 181:5323-5330
NK cells have been proposed to be an initial source of IFN-γ that supports either Th1 or CTL priming. Although NK cells reside in naive lymph nodes (LN) at a very low frequency, they can be recruited into LN draining sites of infection, inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e2a4872cf039231271af957f7e261
https://doi.org/10.4049/jimmunol.181.8.5323
https://doi.org/10.4049/jimmunol.181.8.5323
Publikováno v:
Journal of Leukocyte Biology. 83:106-111
The acquisition of inhibitory MHC-specific receptors occurs during NK cell differentiation and has been considered important in regulating NK cell responsiveness. NK cell differentiation has been studied on the basis of cell surface phenotype, functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ab1582c219f53ec62615096f4a081c
https://doi.org/10.1189/jlb.0707496
https://doi.org/10.1189/jlb.0707496
Autor:
Mark J. Smyth, Fabienne Mackay, Shane T. Grey, Carrie A. Fletcher, Sally V. Watt, Joanna R Groom, Stacey N. Walters, Mathew J. Sweet, Charles R. Mackay
Publikováno v:
The Journal of Experimental Medicine
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies. However, the underlying cause of disease appears to relate to defects in T cell tolerance or T cell help to B cells. Transgenic (Tg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f4320176a606fab254e39aec0e09d5
https://doi.org/10.1084/jem.20062567
https://doi.org/10.1084/jem.20062567
Autor:
Christopher J. Chan, Daniel M. Andrews, Jennifer Poursine-Laurent, Richard Berry, Anthony A. Scalzo, Jamie Rossjohn, Jie Lin, Claire L Cotterell, Mark J. Smyth, Nikola Baschuk, Chyung Ru Wang, Wayne M. Yokoyama, Andrew G. Brooks, Heloise Halse, Sally V. Watt, Lucy C. Sullivan
Publikováno v:
Nature immunology. 13(12)
The development and function of natural killer (NK) cells is regulated by the interaction of inhibitory receptors of the Ly49 family with distinct peptide-laden major histocompatibility complex (MHC) class I molecules, although whether the Ly49 famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247ee9c971984fd7e6ecc7396e0971bc
https://pubmed.ncbi.nlm.nih.gov/23160207
https://pubmed.ncbi.nlm.nih.gov/23160207
Autor:
Joseph A. Trapani, Claire L Cotterell, Shizuo Akira, Yoichiro Iwakura, Yuting Ma, Mark J. Smyth, Desiree A Anthony, Laurence Zitvogel, Daniel M. Andrews, Sally V. Watt, Melvyn T. Chow
Publikováno v:
Immunology and cell biology. 89(6)
Toll-like receptor-4-lipopolysaccharide (LPS)-mediated inflammation is used to delineate signals involved in cross-talk between antigen-presenting cells (APCs) and lymphocytes such as natural killer (NK) cells. Following APC stimulation and cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b7b7a3712fbbe2cb4e5b2eba2a3f17
https://pubmed.ncbi.nlm.nih.gov/21263463
https://pubmed.ncbi.nlm.nih.gov/21263463
Autor:
Phillip I. Bird, Shizou Akira, Sally V. Watt, Desiree A Anthony, Melvyn T. Chow, Joseph A. Trapani, Mark J. Smyth, Daniel M. Andrews, Colin M. House
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(3)
Lymphocyte perforin and serine protease granzymes are well-recognized extrinsic mediators of apoptosis. We now demonstrate that cytotoxic lymphocyte granule components profoundly augment the myeloid cell inflammatory cytokine cascade in response to T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1949e21710a71b2ed43c86f6589885e
https://pubmed.ncbi.nlm.nih.gov/20585036
https://pubmed.ncbi.nlm.nih.gov/20585036