Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Sally Schlessinger"'
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Data from ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
Autor: Alex R. Shoemaker, Steven W. Elmore, Saul H. Rosenberg, Stephen W. Fesik, David J. Frost, Christin Tse, Joy Bauch, Sanjay R. Chemburkar, Baole Wang, Sally Schlessinger, Marion Refici, Anatol Oleksijew, Kelly Foster, Michael J. Mitten, Yu Xiao, Scott Ackler
ABT-263 is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-xL, and Bcl-w, which is currently in phase I clinical trials. Previous work has shown that this compound has low nanomolar cell-killing activity i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8640b021999a65887ca7e614ea2b16d3
https://doi.org/10.1158/1535-7163.c.6531053
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4
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
Autor: Scott L. Ackler, Saul H. Rosenberg, Joy Bauch, Sally Schlessinger, Marion Refici, Kelly Foster, Christin Tse, Sanjay R. Chemburkar, Anatol Oleksijew, David Frost, Michael J. Mitten, Baole Wang, Alex R. Shoemaker, Stephen W. Fesik, Steven W. Elmore, Yu Xiao
Publikováno v: Molecular Cancer Therapeutics. 7:3265-3274
ABT-263 is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-xL, and Bcl-w, which is currently in phase I clinical trials. Previous work has shown that this compound has low nanomolar cell-killing activity i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00074da8c7e1833f3576f6f572622970
https://doi.org/10.1158/1535-7163.mct-08-0268
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5
Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax
Autor: Kelly Foster, Anatol Oleksijew, Jonathan Hickson, Jerry Clarin, Sally Schlessinger, Erwin R. Boghaert, Sasmita Mishra, Jun Chen, Stephen K. Tahir, Scott L. Ackler, Andrew J. Souers, Brenda Chyla, Joel D. Leverson, Thomas McGonigal, Morey L. Smith
Publikováno v: Pharmacology Research & Perspectives
The Bcl-2 family inhibitors venetoclax and navitoclax demonstrated potent antitumor activity in chronic lymphocytic leukemia patients, notably in reducing marrow load and adenopathy. Subsequent trials with venetoclax have been initiated in non-Hodgki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3772111f39b28b66da484405529a70
https://pubmed.ncbi.nlm.nih.gov/26516589
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6
Lesions and Identification of Crystalline Precipitates of Glycoprotein IIb-IIIa Antagonists in the Rat Kidney
Autor: Sally Schlessinger, Jeremy Hribar, Monique M. Fouant, Robert Mark Friedman, Enriqueta Cortez, Mark Nicholas, Nasir K. Khan, Stuart Levin
Publikováno v: Toxicologic Pathology. 27:38-43
Two glycoprotein IIb-IIIa antagonists (xemilofiban, SC-54684A, and orbofiban, SC-57099B), which are platelet aggregation inhibitors, caused crystalline precipitates in the kidney tubules of rats at high dosages. Dogs were not affected. Depending on t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86e377f9a2794e9961450f4da4df66b
https://doi.org/10.1177/019262339902700108
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8
Abstract 858: Potent in vivo activity of the aurora kinase inhibitor ABT-348 in human acute myeloid leukemia and myelodysplastic syndrome xenograft models
Autor: Luis E. Rodriguez, Gail Bukofzer, Joann P. Palma, Yi-Chun Wang, Keith B. Glaser, Daniel M. Albert, Junling Li, Lance Kaleta, Michael R. Michaelides, Jerry Clarin, Sally Schlessinger, Paul Ellis, Chris Tse, Cherrie K. Donawho
Publikováno v: Cancer Research. 72:858-858
The Aurora kinases are a family of serine/threonine kinases that mediate essential functions in cell division. Aurora A depletion results in accumulation of cells in the G2/M phase and apoptosis. Inhibition of Aurora B/C results in abnormal cell divi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd1e858d7eeab805bc434a12345177a9
https://doi.org/10.1158/1538-7445.am2012-858
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10
Simple Method for Orienting Multiple Pieces of Long Thin Tissue for Perfect Paraffin Embedded Cross-Sections
Autor: Sally Schlessinger
Publikováno v: Journal of Histotechnology. 16:165-166
(1993). Simple Method for Orienting Multiple Pieces of Long Thin Tissue for Perfect Paraffin Embedded Cross-Sections. Journal of Histotechnology: Vol. 16, No. 2, pp. 165-166.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9045ad3989d307a0aa2d55e453a65d8f
https://doi.org/10.1179/his.1993.16.2.165
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