Výsledky vyhledávání - "Sally R. Yukiko"

Akademický článek

Dry-coated live viral vector vaccines delivered by nanopatch microprojections retain long-term thermostability and induce transgene-specific T cell responses in mice.

Autor: Frances E Pearson, Celia L McNeilly, Michael L Crichton, Clare A Primiero, Sally R Yukiko, Germain J P Fernando, Xianfeng Chen, Sarah C Gilbert, Adrian V S Hill, Mark A F Kendall

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67888 (2013)

The disadvantages of needle-based immunisation motivate the development of simple, low cost, needle-free alternatives. Vaccine delivery to cutaneous environments rich in specialised antigen-presenting cells using microprojection patches has practical

Externí odkaz: https://doaj.org/article/939bada31aad4beab2f46dab10020487

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CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array

Autor: Mark A. F. Kendall, Nigel A.J. McMillan, Oscar Haigh, Ian H. Frazer, Stefano C. Meliga, Sally R. Yukiko, Alexandra C. I. Depelsenaire

Publikováno v: Journal of Controlled Release. 194:148-156

The barrier morphology of skin provides major obstacles for the application of siRNA for gene silencing, which current delivery technologies do not effectively overcome. Emerging technologies utilise microprojection array devices to penetrate into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3b43eada7aba4013ef66a98759e169
https://doi.org/10.1016/j.jconrel.2014.08.021

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Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8(+) T cell responses

Autor: Sally R. Yukiko, Oscar Haigh, Jin Zhang, Hwee-Ing Ng, Mark A. F. Kendall, Germain J. P. Fernando

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 237

DNA vaccines have many advantages such as thermostability and the ease and rapidity of manufacture; for example, in an influenza pandemic situation where rapid production of vaccine is essential. However, immunogenicity of DNA vaccines was shown to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032364743ea452871f0ee1dc0263ded7
https://pubmed.ncbi.nlm.nih.gov/27381247

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Site-Selectively Coated, Densely-Packed Microprojection Array Patches for Targeted Delivery of Vaccines to Skin

Autor: Sally R. Yukiko, Xianfeng Chen, Emily J. Fairmaid, Holly J. Corbett, Anthony P. Raphael, Lorena E. Brown, Tarl W. Prow, Mark A. F. Kendall, Germain J. P. Fernando

Publikováno v: Advanced Functional Materials. 21:464-473

Densely packed dry-coated microprojections are shown to deliver vaccines to targeted locations within the skin that are rich in immune cells, thus inducing protective immune responses against a lethal virus challenge. Selectively limiting the antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6957995e3800b9dd95b0ff4c56394bc8
https://doi.org/10.1002/adfm.201000966

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Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

Autor: Sally R. Yukiko, Holly J. Corbett, Clare A. Primiero, Xianfeng Chen, Emily J. Fairmaid, Lorena E. Brown, Germain J. P. Fernando, Mark A. F. Kendall, Ian H. Frazer

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 159(2)

Many vaccines make use of an adjuvant to achieve stronger immune responses. Alternatively, potent immune responses have also been generated by replacing the standard needle and syringe (which places vaccine into muscle) with devices that deliver vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410cf17399142d8cca6e137d4697a095
https://pubmed.ncbi.nlm.nih.gov/22306334

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Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin

Autor: Germain J. P. Fernando, Anthony P. Raphael, Emily J. Fairmaid, Mark A. F. Kendall, Lorena E. Brown, Sally R. Yukiko, Clare A. Primiero, Xianfeng Chen, Ian H. Frazer

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 158(1)

A rapid time to peak serum antibody response following vaccination is particularly important for influenza: the time window between the availability of appropriate antigen and the start of the seasonal epidemic is very short. In this paper, influenza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edf4b06f583d3302d2412a5b26238b
https://pubmed.ncbi.nlm.nih.gov/22063004

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Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

Autor: Holly J. Corbett, Alexander B. Ansaldo, Emily J. Fairmaid, Sally R. Yukiko, Lorena E. Brown, Mark A. F. Kendall, Ian H. Frazer, Christopher Flaim, Clare A. Primiero, Germain J. P. Fernando, Michael L. Crichton, Xianfeng Chen

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 152(3)

Dry-coated microprojections can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient immune responses and the dry-coated vaccines are expected to be thermostable at elevated temperatures. In this paper, we show that w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5affbd9ce4c73515141178094bfd0a
https://pubmed.ncbi.nlm.nih.gov/21600940

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Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays

Autor: Courtney Jarrahian, Sally R. Yukiko, Joshua O. Marshak, David M. Koelle, Germain J. P. Fernando, Celia L. McNeilly, Dexiang Chen, Michael L. Crichton, Mark A. F. Kendall, Xianfeng Chen, Angela Shaulov Kask, Lichun Dong

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 148(3)

HSV-2-gD2 DNA vaccine was precisely delivered to immunologically sensitive regions of the skin epithelia using dry-coated microprojection arrays. These arrays delivered a vaccine payload to the epidermis and the upper dermis of mouse skin. Immunomicr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d29b1f2cdaca20187e79632b4cc7f
https://pubmed.ncbi.nlm.nih.gov/20850487

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Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

Autor: Celia L. McNeilly, Adrian V. S. Hill, Sarah C. Gilbert, Sally R. Yukiko, Frances E. Pearson, Michael L. Crichton, Xianfeng Chen, Germain J. P. Fernando, Mark A. F. Kendall, Clare A. Primiero

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67888 (2013)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf296b0b454ce06590acb8b79551606
https://doi.org/10.1371/journal.pone.0067888

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