Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sally R. Gray"'
Autor:
Nathan R. Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K. Umasankar, Antoni G. Wrobel, Jonathan G. G. Kaufman, Sally R. Gray, Kun Qu, Philip R. Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A. G. Briggs, Bernard T. Kelly, David J. Owen, Linton M. Traub
Publikováno v:
Science Advances. 8
Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 requires membrane-localized Fer/Cip4 homology domain-only proteins (FCHO). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b723d388987fce8c7b61442cef921fc
https://doi.org/10.1126/sciadv.abn2018
https://doi.org/10.1126/sciadv.abn2018
Autor:
Christopher M. Sanderson, Andrew A. Peden, Helen M. Kent, J. Paul Luzio, Ingmar B. Schäfer, Sally R. Gray, David J. Owen, Philip R. Evans
Publikováno v:
Developmental Cell
Summary VAMP7 is involved in the fusion of late endocytic compartments with other membranes. One possible mechanism of VAMP7 delivery to these late compartments is via the AP3 trafficking adaptor. We show that the linker of the δ-adaptin subunit of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28da0fb0e2e3c287f16f17659bc3bd04
http://europepmc.org/articles/PMC3549491
http://europepmc.org/articles/PMC3549491
Autor:
J. Paul Luzio, Barbara M. Mullock, Simon C. W. Richardson, Nicholas A. Bright, David E. James, Abigail Stewart, Sally R. Gray, Robert C. Piper, Margaret R. Lindsay, Paul R. Pryor
Publikováno v:
EMBO reports. 5:590-595
Both heterotypic and homotypic fusion events are required to deliver endocytosed macromolecules to lysosomes and remodel late endocytic organelles. A trans-SNARE complex consisting of Q-SNAREs syntaxin 7, Vti1b and syntaxin 8 and the R-SNARE VAMP8 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9963dd000062455d1599c9d7aa334ae
https://doi.org/10.1038/sj.embor.7400150
https://doi.org/10.1038/sj.embor.7400150
Publikováno v:
Molecular Biology of the Cell. 14:4015-4027
Delivery of endocytosed macromolecules to mammalian cell lysosomes occurs by direct fusion of late endosomes with lysosomes, resulting in the formation of hybrid organelles from which lysosomes are reformed. The molecular mechanisms of this fusion ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46488dc7533d37e585b909e7135230e
https://doi.org/10.1091/mbc.e03-01-0040
https://doi.org/10.1091/mbc.e03-01-0040
Publikováno v:
The Journal of Cell Biology
We have investigated the requirement for Ca2+ in the fusion and content mixing of rat hepatocyte late endosomes and lysosomes in a cell-free system. Fusion to form hybrid organelles was inhibited by 1,2-bis(2-aminophenoxy) ethane-N,N,N′,N′-tetraa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2866bdd86a9dcd7a0b120dcabab5be6a
https://doi.org/10.1083/jcb.149.5.1053
https://doi.org/10.1083/jcb.149.5.1053
Publikováno v:
Biochemical Journal. 345:287-296
Endolyn (endolyn-78) is a membrane protein found in lysosomal and endosomal compartments of mammalian cells. Unlike ‘classical’ lysosomal membrane proteins, such as lysosome-associated membrane protein (lamp)-1, it is also present in a subapical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8420191868d7d13f65668013b72237
https://doi.org/10.1042/bj3450287
https://doi.org/10.1042/bj3450287
Publikováno v:
Biochemical Society Transactions. 37:1019-1021
In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late endosomes are MVBs (multivesic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563c27c5f96c86e21f1d616656d9d5b8
https://doi.org/10.1042/bst0371019
https://doi.org/10.1042/bst0371019
Publikováno v:
Biochemical Journal. 341:323-327
It has been proposed that killing of mammalian cells by ricin requires efficient endocytic delivery to the trans-Golgi network (TGN) prior to retrograde transport to the endoplasmic reticulum and entry to the cytosol. In polarized epithelial cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bff179a9e086e5415aa15ff46e5cf60
https://doi.org/10.1042/bj3410323
https://doi.org/10.1042/bj3410323
Publikováno v:
The Journal of Cell Biology
Using a cell-free content mixing assay containing rat liver endosomes and lysosomes in the presence of pig brain cytosol, we demonstrated that after incubation at 37°C, late endosome–lysosome hybrid organelles were formed, which could be isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfec56ac5f421e26669cb9e323d6ba3
https://doi.org/10.1083/jcb.140.3.591
https://doi.org/10.1083/jcb.140.3.591
Autor:
Janet E. Deane, J. Paul Luzio, Edward J. Scourfield, Lena Wartosch, Sally R. Gray, David J. Owen, Stephen C. Graham
The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8255e467be29aa177a76cbdeed5774dd
https://europepmc.org/articles/PMC3746937/
https://europepmc.org/articles/PMC3746937/
