Výsledky vyhledávání - "Sally Loomis"

Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models

Autor: Raphaelle Winsky-Sommerer, Derk-Jan Dijk, Gary Gilmour, Paula de Oliveira, Keith A. Wafford, Sally Loomis

Publikováno v: Neuroscience & Biobehavioral Reviews

The high prevalence of sleep disturbance in neurodegenerative and psychiatric conditions is often interpreted as evidence for both sleep's sensitivity to and causal involvement in brain pathology. Nevertheless, how and which aspects of sleep contribu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d8f94131bc654e33c7e97636b65cab
https://doi.org/10.1016/j.neubiorev.2018.09.027

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Food restriction induces functional resilience to sleep restriction in rats

Autor: Gary Gilmour, Derk-Jan Dijk, Andrew McCarthy, Raphaelle Winsky-Sommerer, Sally Loomis

Publikováno v: Sleep

Study Objectives Sleep restriction (SR) leads to performance decrements across cognitive domains but underlying mechanisms remain largely unknown. The impact of SR on performance in rodents is often assessed using tasks in which food is the reward. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb6a39af7cb15d4ac07fde2eaa1af49
https://surrey.eprints-hosting.org/856983/

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Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist

Autor: Keith A. Wafford, Sally Loomis, Brian J. Eastwood, Nicola Hanley, Andrew McCarthy, Gary Gilmour, Jerome Paulissen

Publikováno v: Sleep. 42(9)

Increasing vigilance without incurring the negative consequences of extended wakefulness such as daytime sleepiness and cognitive impairment is a major challenge in treating many sleep disorders. The present work compares two closely related mGluR2/3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e206fca27769d766cd627972b26366c3
https://pubmed.ncbi.nlm.nih.gov/31106825

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Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617

Autor: Sally Loomis, Christopher Baxter, Gary Gilmour, Mark D. Tricklebank, Dale M. Edgar, Daniel O. Kellett, Andrew McCarthy

Publikováno v: Psychopharmacology

While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8011d89d383121a57130a724e366e93
http://europepmc.org/articles/PMC4600478

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Modelling maintenance of wakefulness in rats: comparing potential non-invasive sleep-restriction methods and their effects on sleep and attentional performance

Autor: Keith A. Wafford, Sally Loomis, Brian J. Eastwood, Gary Gilmour, Andrew McCarthy, Raphaelle Winsky-Sommerer

Publikováno v: Journal of sleep research. 26(2)

While several methods have been used to restrict the sleep of experimental animals, it is often unclear whether these different forms of sleep restriction have comparable effects on sleep-wake architecture or functional capacity. The present study co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6ada008ea08ca85c9001e006c018d6
https://pubmed.ncbi.nlm.nih.gov/27739157

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Diverse and often opposite behavioural effects of NMDA receptor antagonists in rats: implications for 'NMDA antagonist modelling' of schizophrenia

Autor: Rebecca Mason, Michael W. Conway, Wendy T. Jones, Gary Gilmour, Sally Loomis, Elsa Y. Pioli, Sophie Dix, Shahram Shahabi, Mark D. Tricklebank, Janice W. Smith

Publikováno v: Psychopharmacology. 205:203-216

Little attention has been paid to the relative equivalence of behavioural effects of NMDA receptor antagonists in rodents, with different compounds often used interchangeably to “model” aspects of schizophrenia in preclinical studies. To further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0422a3f08a7e43b1b1f155cbd2b8801f
https://doi.org/10.1007/s00213-009-1530-7

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Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum

Autor: Gary Gilmour, Ann Marie L. Ogden, Sally Loomis, Anthony J. Baucum, Teri L. Belecky-Adams, Jonathan M. Wilson, Kalpana M. Merchant

Publikováno v: Neuropharmacology. 99

Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bc2948edce132591d766307b472b5c
https://pubmed.ncbi.nlm.nih.gov/26256420

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Behavioural evidence that modafinil and amphetamine do not produce equivalent qualities of wake promotion in sleep-restricted rats

Autor: Andrew McCarthy, Sally Loomis, Mark D. Tricklebank, Dale M. Edgar, Gary Gilmour

Publikováno v: Sleep Medicine. 14:e185

Introduction Performance effects of sleep restriction are generally assessed across three broad domains: cognitive performance, motor performance and mood. Within the domain of cognition, the psychomotor vigilance task (PVT) provides a means to asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f418465fa9d52604ca1524c06d6f628
https://doi.org/10.1016/j.sleep.2013.11.436

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