Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sally L. D. MacKay"'
Publikováno v:
Scopus-Elsevier
Healing of ocular surface wounds is a complex process involving migration, mitosis, and differentiation of epithelial and stromal cells. Endogenously produced peptide growth factors such as epidermal growth factor (EGF), transforming growth factor al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1fcb592192ecacf822ab8b2dfffad
https://doi.org/10.1111/j.1755-3768.1992.tb02170.x
https://doi.org/10.1111/j.1755-3768.1992.tb02170.x
Autor:
Rene Voboril, Jana Weberova, E. Ramsay Camp, Frank J. Wessels, Steven N. Hochwald, Sally L. D. MacKay, Jing Li, Adam Brank, Lyle L. Moldawer
Publikováno v:
Journal of Surgical Research. 120:178-188
Background 5-fluorouracil (5-FU), the most common antimetabolite used for the treatment of colorectal cancer, exerts its cytotoxic effects through the induction of apoptosis. Folinic acid potentiates the effect of 5-FU. Drug activity is currently lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6694198539407ea9fba6ad722a9542d6
https://doi.org/10.1016/j.jss.2003.11.023
https://doi.org/10.1016/j.jss.2003.11.023
Autor:
Douglas J. Minnich, Sally L. D. MacKay, E. Ramsay Camp, Lyle L. Moldawer, Adam Brank, Steven N. Hochwald, Jing Li
Publikováno v:
Journal of the American College of Surgeons. 199:249-258
Background Activation of nuclear factor-κB (NF-κB) inhibits chemotherapy-induced apoptosis in some cancer cell lines. Inhibition of NF-κB by adenoviral delivery of an IκBα superrepressor (Ad.IκBα-SR) should potentiate 5-fluorouracil (5-FU) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0718b6022a2be634afe6502a482e827
https://doi.org/10.1016/j.jamcollsurg.2004.04.015
https://doi.org/10.1016/j.jamcollsurg.2004.04.015
Autor:
Sally L. D. MacKay, Michael D. Josephs, Edward M. Copeland, Cynthia L. Tannahill, Carl K. Edwards, Riadh Ksontini, Lyle L. Moldawer, Kunitaro Fukuzuka, Carmen C. Solorzano, F. Rena Bahjat
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 278:R1196-R1201
Tumor necrosis factor (TNF)-α and Fas ligand (FasL) are trimeric proteins that induce apoptosis through similar caspase-dependent pathways. Hepatocytes are particularly sensitive to inflammation-induced programmed cell death, although the contributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4022e0a5766e6d39eccd7f2f96825a
https://doi.org/10.1152/ajpregu.2000.278.5.r1196
https://doi.org/10.1152/ajpregu.2000.278.5.r1196
Autor:
Jason J. Rosenberg, Michael D Taylor, David Hirsh, Emmet Hirsch, Carmen C. Solorzano, Sally L. D. MacKay, Daniel Topping, Lyle L. Moldawer, Amer Abouhamze, Mark A. Labow, Michael D. Josephs
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 278:R824-R830
A complete understanding of the role for endogenously produced interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and IL-1 receptor antagonist (IL-1ra) in the acute phase response to inflammation remains unknown. In the present studies, knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69d4e03c1ee903ad75ffe3b672dd1f4
https://doi.org/10.1152/ajpregu.2000.278.4.r824
https://doi.org/10.1152/ajpregu.2000.278.4.r824
Autor:
Sally L. D. MacKay, Lyle L. Moldawer, Kunitaro Fukuzuka, Edward M. Copeland, Tiffany Marum, Cynthia L. Tannahill, Zaher Abouhamze
Publikováno v:
Surgery. 126:349-357
Background. Tumor necrosis factor-α (TNF-α) is a member of a large family of predominantly homotrimeric type II membrane-associated proteins with both proinflammatory and apoptosis-inducing properties. Although TNF-α expression has been studied ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f695eb4b529e0398d87229ceb6bf465a
https://doi.org/10.1016/s0039-6060(99)70176-5
https://doi.org/10.1016/s0039-6060(99)70176-5
Autor:
Michael D. Josephs, Sally L. D. MacKay, Edward M. Copeland, Rebecca M. Minter, Paul D. Edwards, Lyle L. Moldawer
Publikováno v:
Shock. 12:83-101
The application of gene therapy to acute inflammation has not received as much research attention as has the treatment of genetically-based diseases, cancer, and viral infections. However, gene therapy as a drug delivery system offers several theoret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8e4f089c909fa852bf8e04f307dcff
https://doi.org/10.1097/00024382-199908000-00001
https://doi.org/10.1097/00024382-199908000-00001
Publikováno v:
Veterinary Immunology and Immunopathology. 66:1-10
To investigate the ability of recombinant human interleukin 10 (rhuIL-10) to suppress the release of inflammatory mediators from lipopolysaccharide (LPS)-stimulated equine macrophages, rhuIL-10 was added to equine peritoneal macrophage monolayers at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b1b838882ddd4269b6082173b5e8dc
https://doi.org/10.1016/s0165-2427(98)00181-0
https://doi.org/10.1016/s0165-2427(98)00181-0
Autor:
Riadh Ksontini, Dorothy B. Colagiovanni, Michael D. Josephs, Carl K. Edwards, Cynthia L. Tannahill, Carmen C. Solorzano, James Norman, Woody Denham, Michael Clare-Salzler, Sally L. D. MacKay, Lyle L. Moldawer
Publikováno v:
The Journal of Immunology. 160:4082-4089
Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation. In acute inflammation, however, apoptosis triggered by the overproduction of “death factors” such as TNF-α or Fas liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d71298c4cb5ff71552603ff92423460
https://doi.org/10.4049/jimmunol.160.8.4082
https://doi.org/10.4049/jimmunol.160.8.4082
Autor:
Riadh Ksontini, Lyle L. Moldawer, Carmen C. Solorzano, Sally L. D. MacKay, Jeffrey H. Pruitt, Gregory Schultz, Cynthia L. Tannahill, Troy Auffenberg, Edward M. Copeland, Richard E. Galardy
Publikováno v:
Shock. 7:427-431
Excessive tumor necrosis factor alpha (TNF alpha) production in response to Gram-negative bacteremia or endotoxemia can often lead to hypotension, shock, and increased mortality. Current approaches used to block the deleterious effects of exaggerated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107610bc740f5bca5a49a71f94ef0bf
https://doi.org/10.1097/00024382-199706000-00007
https://doi.org/10.1097/00024382-199706000-00007