Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sally L Hampton"'
Autor:
Edward P. Feener, Rebecca L. Davie, Nivetha Murugesan, Stephen J. Pethen, Sally L. Hampton, Michael D. Smith, Paul K. Audhya, Chris M. Yea
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 328-341 (2024)
Sebetralstat is a novel, potent, and selective oral plasma kallikrein inhibitor drug candidate in clinical development for the on-demand treatment of hereditary angioedema (HAE). Upon binding, sebetralstat induces a conformational change in the activ
Externí odkaz:
https://doaj.org/article/c898ea85087542009c61e6fcd2741b8b
Autor:
Allen C. Clermont, Nivetha Murugesan, Hannah J. Edwards, Daniel K. Lee, Natasha P. Bayliss, Edward J. Duckworth, Stephen J. Pethen, Sally L. Hampton, David Gailani, Edward P. Feener
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: The kallikrein kinin system (KKS) is an established pharmacological target for the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic activities of FXIIa and single-chain Factor XII (FXII) zymogen contribute t
Externí odkaz:
https://doaj.org/article/6ba5b7f80e6f4336a608e1a81978ce2e
Autor:
Andreas Maetzel, Michael D. Smith, Edward J. Duckworth, Sally L. Hampton, Gian Marco De Donatis, Nivetha Murugesan, Louise J. Rushbrooke, Lily Li, Danielle Francombe, Edward P. Feener, Christopher M. Yea
Publikováno v:
Journal of Allergy and Clinical Immunology. 149:2034-2042
Attacks of hereditary angioedema are attributed to excessive plasma kallikrein (PKa) activity, which cleaves high-molecular-weight kininogen to generate the proinflammatory hormone bradykinin.We evaluated the safety, tolerability, pharmacokinetics (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d8250a19c23c9a10512bab9913d2f
https://doi.org/10.1016/j.jaci.2021.10.038
https://doi.org/10.1016/j.jaci.2021.10.038
Autor:
Edward J. Duckworth, Nivetha Murugesan, Lily Li, Louise J. Rushbrooke, Daniel K. Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher M. Yea, Sally L. Hampton, Edward P. Feener
Publikováno v:
Clinical & Experimental Allergy. 52:1059-1070
Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity. Current guidelines recommend ready availability of on-demand HAE treatments that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fffe1d47acef7a53a0c4c6b2ef74f0
https://doi.org/10.1111/cea.14122
https://doi.org/10.1111/cea.14122
Autor:
Rebecca L. Davie, Hannah J. Edwards, D. Michael Evans, Simon T. Hodgson, Michael J. Stocks, Alun J. Smith, Louise J. Rushbrooke, Stephen J. Pethen, Michael B. Roe, David E. Clark, Paul A. McEwan, Sally L. Hampton
Publikováno v:
Journal of medicinal chemistry. 65(20)
Hereditary angioedema (HAE) is a rare genetic disorder in which patients experience sudden onset of swelling in various locations of the body. HAE is associated with uncontrolled plasma kallikrein (PKa) enzyme activity and generation of the potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a942bb14681cf9da9bb4d6a511564e
https://pubmed.ncbi.nlm.nih.gov/36251573
https://pubmed.ncbi.nlm.nih.gov/36251573
Autor:
Lily Li, Edward Duckworth, Michael D. Smith, Andreas Maetzel, Louise J. Rushbrooke, Sally L. Hampton, Gian Marco De Donatis, Nivetha Murugesan, Edward P. Feener, Christopher M. Yea, Rachel M. Morten
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:AB39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a3eb5a276cf13efee6943be9f6c0e3
https://doi.org/10.1016/j.jaci.2018.12.118
https://doi.org/10.1016/j.jaci.2018.12.118
Autor:
William R. Ford, Kenneth J. Broadley, Dominic J. Corkill, Elinor John, D M. Evans, Emma Jane Kidd, Sally L. Hampton
Publikováno v:
D31. ANIMAL MODELS OF AIRWAY INFLAMMATION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7626c04a0dd3e57ed8ea743c87a4dd0
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5592
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5592
Autor:
Anne I. Kinnaird, Sally L. Hampton
Publikováno v:
Cell biology and toxicology. 26(1)
Functional cellular assays are the bedrock of modern drug discovery. These utilise cellular systems that yield a measurable biochemical product or physiological response to drug stimulation. Often, these functional responses are studied by the introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1715817c2f5ff01b0bac810a8916a1cf
https://pubmed.ncbi.nlm.nih.gov/19904619
https://pubmed.ncbi.nlm.nih.gov/19904619
Autor:
James Barnett, Andy Sheppard, Andy J Baxter, Robert Haigh, Doreen Mary Ashworth, John Horton, Janice D Broadbridge, Michael Bryan Roe, Christine Elizabeth Allan, Richard Jeremy Franklin, Sally L Hampton, Peter A. Robson, Graeme San Diego Semple, Andy M Penson, Pierre Riviere, Rooker David Philip, Peter Hudson, Pitt Gary Robert William, Yea Christopher Martyn, Paul David Jenkins
Publikováno v:
Journal of medicinal chemistry. 51(24)
Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5811e23f6391edc618cca30c4ed2af9b
https://pubmed.ncbi.nlm.nih.gov/19053774
https://pubmed.ncbi.nlm.nih.gov/19053774
Autor:
Feener, Edward P.1 (AUTHOR) epf@kalvista.com, Davie, Rebecca L.2 (AUTHOR) rld@kalvista.com, Murugesan, Nivetha1 (AUTHOR) mds@kalvista.com, Pethen, Stephen J.2 (AUTHOR) sjp@kalvista.com, Hampton, Sally L.2 (AUTHOR) slh@kalvista.com, Smith, Michael D.1 (AUTHOR) pka@kalvista.com, Audhya, Paul K.1 (AUTHOR), Yea, Chris M.2 (AUTHOR) cmy@kalvista.com
Publikováno v:
Drugs & Drug Candidates. Jun2024, Vol. 3 Issue 2, p328-341. 14p.