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pro vyhledávání: '"Sally J. Mattern"'
Autor:
Steve A. Mizsak, Thomas F. DeKoning, Sally J. Mattern, David A. Yurek, Ming-Shang Kuo, Mark D. Prairie
Publikováno v:
Journal of Pharmaceutical Sciences. 88:705-708
PNU‐107859, an important representative structure in a novel class of matrix metalloproteinases (MMP) inhibitors known as thiadiazoles, was found to be quickly eliminated from rats. A major metabolite (approximately 10% of total dose) was found to