Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sally J. Hargus"'
Publikováno v:
Chemical Research in Toxicology. 8:993-996
Diclofenac is a nonsteroidal anti-inflammatory drug that has been implicated in several cases of severe hepatotoxicity. Our previous study showed that diclofenac metabolites bound covalently and selectively to rat liver plasma membrane proteins with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a90ef2fb6700f657554c7ac68a79d9
https://doi.org/10.1021/tx00050a001
https://doi.org/10.1021/tx00050a001
Autor:
M. W. Anders, Sally J. Hargus
Publikováno v:
Biochemical Pharmacology. 42:R17-R20
The nephrotoxicity of several haloalkenes is associated with glutathione S -conjugate formation, metabolism of the glutathione S -conjugate to the corresponding cysteine S -conjugate and translocation to the kidney, and metabolism by renal cysteine c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880eda5c4b2aea34f7f068add27c9197
https://doi.org/10.1016/0006-2952(91)90580-x
https://doi.org/10.1016/0006-2952(91)90580-x
Publikováno v:
Biochemistry. 30:717-721
The stereochemistry of S-(2-chloro-1,1,2-trifluoroethyl)glutathione formation was studied in rat liver cytosol, microsomes, N-ethylmaleimide-treated microsomes, 9000g supernatant fractions, purified rat liver microsomal glutathione S-transferase, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a024352c2b0bb2a99317d87af05e5d
https://doi.org/10.1021/bi00217a020
https://doi.org/10.1021/bi00217a020
Autor:
Davis H. Daiker, Walter E. Hoffmann, Chessley R. Atchison, Lance R. Pohl, Bryan K. Shipp, A. Brian West, Arun Balakumaran, Judith F. Aronson, Sally J. Hargus, Mary Treinen Moslen
Publikováno v:
Gastroenterology. 119(6)
Background & Aims: Enteropathy is a frequent complication of diclofenac and other nonsteroidal anti-inflammatory drugs, yet little is known about the underlying mechanism. One possibility is that reactive metabolites of diclofenac form adducts with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f3c44d76a1b0548634068388300466
https://pubmed.ncbi.nlm.nih.gov/11398796
https://pubmed.ncbi.nlm.nih.gov/11398796
Publikováno v:
Chemical research in toxicology. 10(4)
Diclofenac antiserum was previously developed and used to detect protein adducts of metabolites of dichlofenac in livers of mice and rats. In this study, the antibody has been used to facilitate the purification of a major 51 kDa microsomal adduct of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775e7ac1d9cba5eedfb9f58c01cef6e5
https://pubmed.ncbi.nlm.nih.gov/9114979
https://pubmed.ncbi.nlm.nih.gov/9114979
Autor:
Lance R. Pohl, Neil R. Pumford, Sally J. Hargus, Stacie C. McCoy, Hamid R. Amouzedeh, Timothy G. Myers
Publikováno v:
Chemical research in toxicology. 7(4)
Diclofenac is a nonsteroidal anti-inflammatory agent that is reported to cause serious hepatic injury in some patients. To investigate the possibility that protein adducts derived from reactive intermediates of diclofenac might be responsible for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ac951563e9bbcf9f0f1ced17ff8f49
https://pubmed.ncbi.nlm.nih.gov/7981423
https://pubmed.ncbi.nlm.nih.gov/7981423
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468458794
Glutathione S-transferases catalyze the nucleophilic addition of glutathione to electrophilic substrates. Glutathione S-conjugate formation, followed by conversion to mercapturates, serves to detoxify potentially harmful xenobiotics. Alternatively, g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360fd98579f13bbaea75fc52106ea016
https://doi.org/10.1007/978-1-4684-5877-0_34
https://doi.org/10.1007/978-1-4684-5877-0_34
Publikováno v:
Arthritis & Rheumatism. 37:1557-1557
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb650708983243550091436dd1154b2
https://doi.org/10.1002/art.1780371024
https://doi.org/10.1002/art.1780371024