Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sally I. Eissa"'
Autor:
Abdallah E. Abdallah, Reda R. Mabrouk, Maged Mohammed Saleh Al Ward, Sally I. Eissa, Eslam B. Elkaeed, Ahmed B. M. Mehany, Mariam A. Abo-Saif, Ola A. El-Feky, Mohamed S. Alesawy, Mohamed Ayman El-Zahabi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 573-591 (2022)
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared
Externí odkaz:
https://doaj.org/article/3af1c5c676984e4bb4c5c70fd837b96c
Autor:
Mohamed Ayman El-Zahabi, Hazem Elkady, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Khaled. El-Adl
In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized compounds were evaluated for their cytotoxic activities against HepG-2, HCT-116, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db46a196ec3fac0d375af3a1051e6213
Autor:
Esmail M. El-Fakharany, Mohamed H. Kalaba, Abdallah E. Abdallah, Hazem Elkady, Noura M. Abo Shama, Mohamed H. Sharaf, Ahmed Mostafa, Sally I. Eissa, Sara H. Mahmoud, Ahmed A. Al-Karmalawy, Mohamed S Alesawy
Publikováno v:
New Journal of Chemistry. 45:16557-16571
Regarding the crucial role of deubiquitinase (DUB) enzymes in many viruses, in particular, Adenovirus, HSV-1, coxsackievirus, and SARS-CoV-2, DUB inhibition was reported as an effective new approach to find new effective antiviral agents. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40b4f2c343ef55369f93d0f8046a0f5
https://doi.org/10.1039/d1nj02710g
https://doi.org/10.1039/d1nj02710g
Autor:
Sally I. Eissa, Samir Y. Abbas, Mohamed F. El Shehry, Yousry A. Ammar, Eman A. Fayed, Amel M. Farrag, Ahmed Ragab
Publikováno v:
Bioorganic chemistry. 110
One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of quinolines bearing a thiazole moiety were synthesized using thiosemicarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99599309a19c1d0b6d189f757ef0cc2b
https://pubmed.ncbi.nlm.nih.gov/33761314
https://pubmed.ncbi.nlm.nih.gov/33761314
Autor:
Hazem Elkady, Mohamed El-Zahabi, Helmy Sakr, Khaled El-Adl, Sally I. Eissa, Mohamed F. Zayed, Ibrahim H. Eissa, Adel S. Abdelraheem
Publikováno v:
Bioorganic chemistry. 104
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of certain inflammatory mediators associated with cancer. In the present work, a new series of thalidomide analogs was designed and synthesized to obtain new effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42292ad44a1eee0e70d964ac132b8801
https://pubmed.ncbi.nlm.nih.gov/32932121
https://pubmed.ncbi.nlm.nih.gov/32932121
Autor:
Sawsan A. Fouad, Sally I. Eissa, Amel M. Farrag, Yousry A. Ammar, Samir Y. Abbas, Mohamed F. El Shehry
Publikováno v:
Medicinal Chemistry Research. 27:2287-2296
Novel series of quinaxoline derivatives incorporating N-propionic and O-propionic hydrazide moieties were synthesized. Alkylation of 3-methylquinoxalin-2(1H)-one with ethyl 2-bromopropanoate afforded a mixture of O-alkylated and N-alkylated 3-methylq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810ebaa42fdfbb81f5438240ac295336
https://doi.org/10.1007/s00044-018-2235-4
https://doi.org/10.1007/s00044-018-2235-4
Autor:
Sally I. Eissa, André M. Beauchemin, Ahmed B.M. Mehany, Nawaf A. Alsaif, Mohamed K. Ibrahim, Ibrahim H. Eissa, Mohammed A. Dahab, A.Z. Alanazi
Publikováno v:
Bioorganic Chemistry. 112:104965
Thirty-five new colchicine binding site inhibitors have been designed and synthesized based on the 1,2,4-triazin-3(2H)-one nucleus. Such molecules were synthesized through a cascade reaction between readily accessible α-amino ketones and phenyl carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d632a2aeaed5774894fcd38a6a0da27d
https://doi.org/10.1016/j.bioorg.2021.104965
https://doi.org/10.1016/j.bioorg.2021.104965
Publikováno v:
Medicinal Chemistry Research. 26:2375-2398
Antibiotic resistance is a major health problem; so there is a emerging need for developing new antibiotic agents. A novel series of (6-methoxy-2-naphthyl) propanamide derivatives were synthesized and evaluated for their potential antibacterial activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47962c013540599a7a27e7c19369907c
https://doi.org/10.1007/s00044-017-1939-1
https://doi.org/10.1007/s00044-017-1939-1
Autor:
Sally I. Eissa
Publikováno v:
Medicinal Chemistry Research. 26:2205-2220
Focusing particularly on colorectal cancer, and suggesting research strategies that may help to accelerate the future clinical application of indomethacin for the treatment of cancer, the molecular structures of indomethacin was used as starting scaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5668f96e8bebc62ab362ab98964a23
https://doi.org/10.1007/s00044-017-1932-8
https://doi.org/10.1007/s00044-017-1932-8
Autor:
Maged Mohammed Saleh Al Ward, Ahmed B.M. Mehany, Mohamed El-Zahabi, Reda R. Mabrouk, Abdallah E. Abdallah, Sally I. Eissa
Publikováno v:
Bioorganic Chemistry. 109:104695
Globally cancer is the second leading cause of death. So that this work is an attempt to develop new effective anti-cancer agents. In line with pharmacophoric features of VEGFR-2 kinase inhibitors, new nineteen quinazolin-4-one derivatives were desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15955ffd888a215ded4f3666ee62a37b
https://doi.org/10.1016/j.bioorg.2021.104695
https://doi.org/10.1016/j.bioorg.2021.104695