Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sally Fuess"'
Autor:
Helen M. Blau, Christian Trautwein, D. Denison Jenkins, Joseph Lin, Judith A. Shizuru, Regis Doyonnas, Scott V. Perryman, Karl G. Sylvester, Konrad L. Streetz, Dirk Grimm, Mark A. Kay, Sally Fuess
Publikováno v:
Hepatology. 47:706-718
The lack of adequate donor organs is a major limitation to the successful widespread use of liver transplantation for numerous human hepatic diseases. A desirable alternative therapeutic option is hepatocyte transplantation (HT), but this approach is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a338e019f565fb7a4ea32b5c731c52
https://doi.org/10.1002/hep.22012
https://doi.org/10.1002/hep.22012
Autor:
Bassel Akache, Dariya S. Glazer, Julie Park, Mark A. Kay, Sally Fuess, Dirk Grimm, Xuan Shen, Stephen R. Yant
Publikováno v:
Molecular Therapy
Vectors based on different serotypes of adeno-associated virus hold great promise for human gene therapy, based on their unique tissue tropisms and distinct immunological profiles. A particularly interesting candidate is AAV8, which can efficiently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d01b1ef542235a51a02284addda018
Autor:
Katsuya Inagaki, Gregory A. Gibson, Theresa A. Storm, Mark A. Kay, Sally Fuess, Charles F. McTiernan, Hiroyuki Nakai
Publikováno v:
Molecular Therapy. 14(1):45-53
It has been recently shown that recombinant adeno-associated virus serotype 8 (rAAV8) is a robust alternative serotype vector that overcomes many of the limitations of rAAV2 and transduces various tissues efficiently and globally through systemic vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf8652357fb621c4a711ad1e7d13f07
Autor:
Hiroyuki Nakai, Michael A. Lochrie, Shangzhen Zhou, Takashi Matsushita, Alan McClelland, Leonard Meuse, Richard T. Surosky, Mark A. Kay, Sally Fuess, Dirk Grimm, Clare E. Thomas, James R. Allen, Peter Colosi, Theresa A. Storm
Publikováno v:
Blood. 102:2412-2419
We report the generation and use of pseudotyped adeno-associated viral (AAV) vectors for the liver-specific expression of human blood coagulation factor IX (hFIX). Therefore, an AAV-2 genome encoding the hfIX gene was cross-packaged into capsids of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1dce55bd07a86039709140cce3f050
https://doi.org/10.1182/blood-2003-02-0495
https://doi.org/10.1182/blood-2003-02-0495
Publikováno v:
Human Gene Therapy. 14:871-881
Elucidation of the mechanisms of transformation of single-stranded (ss) recombinant adeno-associated virus (rAAV) vector genomes into a variety of stable double-stranded (ds) forms is key to a complete understanding of rAAV vector transduction in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865f9b4ea6b4b6b1e28ead1bce23faf7
https://doi.org/10.1089/104303403765701169
https://doi.org/10.1089/104303403765701169
Autor:
Leonard Meuse, Mark A. Kay, Sally Fuess, Theresa A. Storm, Milton J. Finegold, Markus Grompe, Hiroyuki Nakai, Eugenio Montini
Publikováno v:
Molecular Therapy. 7(1):101-111
Nonviral plasmid DNA is a promising vector for achieving ex vivo and in vivo gene transfer. However, transgene expression is usually transient, especially in dividing target cells due to loss of vector genomes. Here we describe the use of naked doubl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c23fded5b6897e745805a5a16f46f
Autor:
Susanna M. Lewis, Theresa A. Storm, David J. Munroe, Hiroyuki Nakai, Congrong Ma, Katsuya Inagaki, Xiaolin Wu, Mark A. Kay, Sally Fuess
Publikováno v:
Journal of virology. 81(20)
Adeno-associated virus (AAV) is a small nonpathogenic, replication-defective DNA virus with a single-stranded DNA genome. Recombinant AAV (rAAV) is among the most promising gene delivery vectors for human gene therapy (15, 28). rAAV lacks machinery f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6b8aaefafae7975f21e8f6fa156460
https://pubmed.ncbi.nlm.nih.gov/17686840
https://pubmed.ncbi.nlm.nih.gov/17686840
Publikováno v:
Molecular Therapy. 13
rAAV8 vectors transduce various tissues with extremely high efficiency in neonates and infants. Many applications of rAAV8 vector injection into prenatal or neonatal mice have been proposed to treat various disorders. Intraperitoneal or intravascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1156ddcbd84591d62e5585938312815e
Publikováno v:
Journal of virology. 79(1)
Recombinant adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small portion of hepatocytes even after adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0aea2d706b91b578739c244eb394f0d
https://pubmed.ncbi.nlm.nih.gov/15596817
https://pubmed.ncbi.nlm.nih.gov/15596817
Publikováno v:
Nature genetics. 34(3)
Recombinant adeno-associated virus serotype 2 (rAAV2) is a promising vector for gene therapy because it can achieve long-term stable transgene expression in animals and human subjects after direct administration of vectors into various target tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e9cc5a13e9e2d46a5bb43e46f8460
https://pubmed.ncbi.nlm.nih.gov/12833043
https://pubmed.ncbi.nlm.nih.gov/12833043