Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Sally Freeman"'
Autor:
Paula I. Seoane, James A. Beswick, Andrew G. Leach, Tessa Swanton, Lucy V. Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The NLRP3 inflammasome is a component of the inflammatory response to infection and injury, orchestrating the maturation and release of the pro-inflammatory cytokines interleukin-1β (IL-1β), IL-18, and triggering pyroptotic cell death. App
Externí odkaz:
https://doaj.org/article/38f74ab91955427e865abe6c6a9ba28b
Autor:
Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, Paul R. Kasher
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108968- (2024)
Summary: Excessive or aberrant NLRP3 inflammasome activation has been implicated in the progression and initiation of many inflammatory conditions; however, currently no NLRP3 inflammasome inhibitors have been approved for therapeutic use in the clin
Externí odkaz:
https://doaj.org/article/0f496b494bea49a4bf551e605784fa33
Autor:
Jack P. Green, Lina Y. El-Sharkawy, Stefan Roth, Jie Zhu, Jiayu Cao, Andrew G. Leach, Arthur Liesz, Sally Freeman, David Brough
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106758- (2023)
Summary: Inflammation driven by DNA sensors is now understood to be important to disease pathogenesis. Here, we describe new inhibitors of DNA sensing, primarily of the inflammasome forming sensor AIM2. Biochemistry and molecular modeling has reveale
Externí odkaz:
https://doaj.org/article/e6aa52cb874948d1a073077fbf553b34
Autor:
Rachael N. Magwaza, Muna Abubaker, Buthaina Hussain, Michael Haley, Kevin Couper, Sally Freeman, Niroshini J. Nirmalan
Publikováno v:
Molecules, Vol 28, Iss 18, p 6471 (2023)
The emergence of resistance to first-line antimalarial drugs calls for the development of new therapies for drug-resistant malaria. The efficacy of quinoline-based antimalarial drugs has prompted the development of novel quinolines. A panel of 4-amin
Externí odkaz:
https://doaj.org/article/68f7c61eab1b421f9ba0483bedd133b6
Publikováno v:
Molecules, Vol 28, Iss 15, p 5753 (2023)
Many transmembrane proteins are modulated by intracellular or extracellular pH. Investigation of pH dependence generally proceeds by mutagenesis of a wide set of amino acids, guided by properties such as amino-acid conservation and structure. Predict
Externí odkaz:
https://doaj.org/article/69cbc04234624630bcf7bf2644ef3502
Autor:
Fred Mulroe, Wei-Hsiang Lin, Connie Mackenzie-Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R. Ryley Parrish, Ilse Smolders, Andrew Trevelyan, Robert C. Wykes, Stuart Allan, Sally Freeman, Richard A. Baines
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/3c30c2a06d484e9abf1e1f9a183c7038
Publikováno v:
Molecules, Vol 28, Iss 8, p 3317 (2023)
Bestrophin 1 (Best1) is a chloride channel that localises to the plasma membrane of retinal pigment epithelium (RPE) cells. Mutations in the BEST1 gene are associated with a group of untreatable inherited retinal dystrophies (IRDs) called bestrophino
Externí odkaz:
https://doaj.org/article/2e884a38174043fbbad87c044cc5fddf
Publikováno v:
Molecules, Vol 27, Iss 19, p 6213 (2022)
The NLRP3 inflammasome is currently an exciting target for drug discovery due to its role in various inflammatory diseases; however, to date, no NLRP3 inhibitors have reached the clinic. Several studies have used natural products as hit compounds to
Externí odkaz:
https://doaj.org/article/afdc3102f7274f47bef0fa62f7117612
Autor:
Izzeddin Alsalahat, Zubida M. Al-Majdoub, Mutasem O. Taha, Jill Barber, Harmesh Aojula, Nigel Hodson, Sally Freeman
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100943- (2021)
The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic benzylpenicillin (BP) can specifically bind to Aβ, modulate the process of aggregation a
Externí odkaz:
https://doaj.org/article/2b65d79699e9452e8c0e4c4c4b236517
Autor:
Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Shi Yu, James Beswick, Antony D Adamson, Neil E Humphreys, Richard Bryce, Sally Freeman, Catherine Lawrence, David Brough
Publikováno v:
eLife, Vol 9 (2020)
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s
Externí odkaz:
https://doaj.org/article/357c06ff09e049e6a8dc9b264dc697bf