Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries

Autor: Biljana Kakaraskoska Boceska, Tuba Vilken, Basil Britto Xavier, Tomislav Kostyanev, Qiang Lin, Christine Lammens, Sally Ellis, Seamus O’Brien, Renata Maria Augusto da Costa, Aislinn Cook, Neal Russell, Julia Bielicki, Amy Riddell, Wolfgang Stohr, Ann Sarah Walker, Eitan Naaman Berezin, Emmanuel Roilides, Maia De Luca, Lorenza Romani, Daynia Ballot, Angela Dramowski, Jeannette Wadula, Sorasak Lochindarat, Suppawat Boonkasidecha, Flavia Namiiro, Hoang Thi Bich Ngoc, Minh Dien Tran, Tim R. Cressey, Kanchana Preedisripipat, James A. Berkley, Robert Musyimi, Charalampos Zarras, Trusha Nana, Andrew Whitelaw, Cely Barreto da Silva, Prenika Jaglal, Willy Ssengooba, Samir K. Saha, Mohammad Shahidul Islam, Marisa Marcia Mussi-Pinhata, Cristina Gardonyi Carvalheiro, Laura J. V. Piddock, Paul T. Heath, Surbhi Malhotra-Kumar, Michael Sharland, Youri Glupczynski, Herman Goossens

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved trea

Externí odkaz: https://doaj.org/article/96086d94019d4d67999839b0ced29734

Estimating the impact of test–trace–isolate–quarantine systems on SARS-CoV-2 transmission in Australia

Autor: Freya M. Shearer, James M. McCaw, Gerard E. Ryan, Tianxiao Hao, Nicholas J. Tierney, Michael J. Lydeamore, Logan Wu, Kate Ward, Sally Ellis, James Wood, Jodie McVernon, Nick Golding

Publikováno v: Epidemics, Vol 47, Iss , Pp 100764- (2024)

Background:: Australian states and territories used test–trace–isolate–quarantine (TTIQ) systems extensively in their response to the COVID-19 pandemic in 2020-2021. We report on an analysis of Australian case data to estimate the impact of tes

Externí odkaz: https://doaj.org/article/b9d3746396df4fce97cc0b8666c5c040

Practices and challenges related to antibiotic use in paediatric treatment in hospitals and health centres in Niger and Uganda: a mixed methods study

Autor: Grace Mambula, Deborah Nanjebe, Aurelia Munene, Ousmane Guindo, Aichatou Salifou, Abdoul-Aziz Mamaty, Susan Rattigan, Sally Ellis, Nathalie Khavessian, Rob W van der Pluijm, Caroline Marquer, Irene Aicha Adehossi, Céline Langendorf

Publikováno v: Antimicrobial Resistance and Infection Control, Vol 12, Iss 1, Pp 1-12 (2023)

Abstract Background Antibiotic resistance is a significant public health problem and is responsible for high mortality in children and new-borns. Strengthening the rational use of antibiotics and improving the quality and access to existing antibioti

Externí odkaz: https://doaj.org/article/1e2b82716279441bb6bd8e5be9250d93

Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).

Autor: Neal J Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook, James A Berkley, Bethou Adhisivam, Ramesh Agarwal, Nawshad Uddin Ahmed, Manica Balasegaram, Daynia Ballot, Adrie Bekker, Eitan Naaman Berezin, Davide Bilardi, Suppawat Boonkasidecha, Cristina G Carvalheiro, Neema Chami, Suman Chaurasia, Sara Chiurchiu, Viviane Rinaldi Favarin Colas, Simon Cousens, Tim R Cressey, Ana Carolina Dantas de Assis, Tran Minh Dien, Yijun Ding, Nguyen Trong Dung, Han Dong, Angela Dramowski, Madhusudhan Ds, Ajay Dudeja, Jinxing Feng, Youri Glupczynski, Srishti Goel, Herman Goossens, Doan Thi Huong Hao, Mahmudul Islam Khan, Tatiana Munera Huertas, Mohammad Shahidul Islam, Daniel Jarovsky, Nathalie Khavessian, Meera Khorana, Angeliki Kontou, Tomislav Kostyanev, Premsak Laoyookhon, Sorasak Lochindarat, Mattias Larsson, Maia De Luca, Surbhi Malhotra-Kumar, Nivedita Mondal, Nitu Mundhra, Philippa Musoke, Marisa M Mussi-Pinhata, Ruchi Nanavati, Firdose Nakwa, Sushma Nangia, Jolly Nankunda, Alessandra Nardone, Borna Nyaoke, Christina W Obiero, Maxensia Owor, Wang Ping, Kanchana Preedisripipat, Shamim Qazi, Lifeng Qi, Tanusha Ramdin, Amy Riddell, Lorenza Romani, Praewpan Roysuwan, Robin Saggers, Emmanuel Roilides, Samir K Saha, Kosmas Sarafidis, Valerie Tusubira, Reenu Thomas, Sithembiso Velaphi, Tuba Vilken, Xiaojiao Wang, Yajuan Wang, Yonghong Yang, Liu Zunjie, Sally Ellis, Julia A Bielicki, A Sarah Walker, Paul T Heath, Mike Sharland

Publikováno v: PLoS Medicine, Vol 20, Iss 6, p e1004179 (2023)

BackgroundThere is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predictin

Externí odkaz: https://doaj.org/article/72ca0b6efbd84ba3bf3e40c592391f16

The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

Autor: Alessia Savoldi, Elena Carrara, Laura J. V. Piddock, Francois Franceschi, Sally Ellis, Margherita Chiamenti, Damiano Bragantini, Elda Righi, Evelina Tacconelli

Publikováno v: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)

Abstract Background Effective treatment of sepsis due to carbapenem-resistant Gram-negative bacteria (CR-GNB) remains a challenge for clinicians worldwide. In recent years, the combination of antibiotics has become the preferred treatment strategy fo

Externí odkaz: https://doaj.org/article/58c0b235e9024a74af9db72548085ad1