Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Sally Beard"'
Autor:
Haineng Xu, Sarah B. Gitto, Gwo-Yaw Ho, Sergey Medvedev, Kristy Shield-Artin, Hyoung Kim, Sally Beard, Yasuto Kinose, Xiaolei Wang, Holly E. Barker, Gayanie Ratnayake, Wei-Ting Hwang, Ryan J. Hansen, Bryan Strouse, Snezana Milutinovic, Christian Hassig, Matthew J. Wakefield, Cassandra J. Vandenberg, Clare L. Scott, Fiona Simpkins
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109978- (2024)
Summary: High-grade serous ovarian cancers (HGSOCs) with homologous recombination deficiency (HRD) are initially responsive to poly (ADP-ribose) polymerase inhibitors (PARPi), but resistance ultimately emerges. HGSOC with CCNE1 amplification (CCNE1am
Externí odkaz:
https://doaj.org/article/1ed5cdda17844d2e8fc282a3b801056b
Autor:
Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Sally Beard, Danielle A. Debruin, Alan Hayes, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. Tocolytics are drugs used in cases of imminent preterm birth to inhibit uterine contractions. Nifedipine is a calcium channel blocking agent used to delay t
Externí odkaz:
https://doaj.org/article/ecae7aa9492148a588dc9ec772536a2e
Autor:
Bianca R. Fato, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Natasha de Alwis, Natalie J. Hannan
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2660 (2023)
Gestational diabetes mellitus (GDM) is a condition of pregnancy defined by new-onset hyperglycemia. GDM is associated with impaired maternal endothelial and vascular reactivity. Endothelin-1 (ET-1) is a potent vasoconstrictor that contributes to endo
Externí odkaz:
https://doaj.org/article/c4d4ec67fad0462a9d66aeeffb7c39f9
Autor:
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) transcripts are elevated in the circulation of individuals whose pregnancies are complicated by preterm fetal growth restriction (FGR). In this paper, we show that the cases with preeclam
Externí odkaz:
https://doaj.org/article/fd7a986eec1140abaec2740950069538
Autor:
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Lisa Hui, Stephen Tong, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Previously, we identified increased maternal circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction (FGR). Here, we assessed whether circulating DAAM2 mRNA could detect FGR, and whether the DAAM2 gene, known to
Externí odkaz:
https://doaj.org/article/651f19d9ebf742ba844ba2da24a85f7f
Autor:
Natalie K. Binder, Sally Beard, Natasha de Alwis, Bianca R. Fato, Tuong-Vi Nguyen, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6182 (2023)
Preeclampsia is associated with an increased lifelong risk of cardiovascular disease (CVD). It is not clear whether this is induced by persistent systemic organ and vascular damage following preeclampsia or due to a predisposition to both conditions
Externí odkaz:
https://doaj.org/article/2a303682986d41c091fe5fe2038086cb
Autor:
Natalie J. Hannan, Paul A. Cohen, Sally Beard, Sanela Bilic, Bonnie Zhang, Stephen Tong, Clare Whitehead, Lisa Hui
Publikováno v:
Gynecologic Oncology Reports, Vol 39, Iss , Pp 100894- (2022)
Background: High-grade serous tubo-ovarian cancer (HGSC) is the most common histological subtype of epithelial ovarian cancer, and highly lethal. Currently there is no effective screening test and prognosis is poor as the majority of cases are diagno
Externí odkaz:
https://doaj.org/article/f95182e79f204e9890ae4805c43d4fe4
Autor:
Natalie J. Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L. David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Stephen Tong
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placental insufficiency wit
Externí odkaz:
https://doaj.org/article/5038f8b3592448bf89b3883d5313043b
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0271560 (2022)
Preeclampsia is a multi-system disease that can have severe, even fatal implications for the mother and fetus. Abnormal placentation can lead to ischaemic tissue injury and placental inflammation. In turn, the placenta releases anti-angiogenic factor
Externí odkaz:
https://doaj.org/article/ce41406c48294099971b0d7847ef6f09
Autor:
Bianca R. Fato, Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10852 (2022)
New-onset maternal hypertension is a hallmark of preeclampsia, driven by widespread endothelial dysfunction and systemic vasoconstriction. Here, we set out to create a new ex vivo model using preeclamptic serum to cause injury to the endothelium, mim
Externí odkaz:
https://doaj.org/article/a4329a6751cd45d88b1556996e14d849