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Autor:
Peter Tobin, Michael Crawford, Tony Eyers, Michael J. Solomon, Stephen Clarke, Laurent P. Rivory, James J. Gallagher, Soon C. Lee, Sally Aulds, J. Paul Seale
Publikováno v:
British journal of clinical pharmacology. 62(1)
Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study wa