Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Sally Ann Cryan"'
Autor:
Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 779 (2021)
Heart failure has a five-year mortality rate approaching 50%. Inducing angiogenesis following a myocardial infarction is hypothesized to reduce cardiomyocyte death and tissue damage, thereby preventing heart failure. Herein, a novel nano-in-gel deliv
Externí odkaz:
https://doaj.org/article/a21fcaf49fcc4a58836dddb2d22007ed
Autor:
Joanne O’Dwyer, Megan Cullen, Sarinj Fattah, Robert Murphy, Smiljana Stefanovic, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 513 (2020)
Stromal-Derived Factor 1α (SDF) is an angiogenic, chemotactic protein with significant potential for applications in a range of clinical areas, including wound healing, myocardial infarction and orthopaedic regenerative approaches. The 26-min in viv
Externí odkaz:
https://doaj.org/article/d4b1b26ac1bf4e6eb4145cd5301eb376
Publikováno v:
Medicines, Vol 5, Iss 4, p 133 (2018)
Background: microRNA (miRNA) regulate target gene expression through translational repression and/or mRNA degradation and are involved in the regulation of inflammation. Macrophages are key inflammatory cells that are important in chronic inflammator
Externí odkaz:
https://doaj.org/article/b97da50d64984b03889576feb85f6dfc
Autor:
Claire Wynne, Elisa Lazzari, Siobhán Smith, Eoghan M McCarthy, Joan Ní Gabhann, Lara E Kallal, Rowan Higgs, Angela Greco, Sally Ann Cryan, Christine A Biron, Caroline A Jefferies
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101503 (2014)
In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral imm
Externí odkaz:
https://doaj.org/article/58700cfb9d73451886aa4ee9bc8ab3ba
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Attempted tracheal replacement efforts thus far have had very little success. Major limiting factors have been the inability to efficiently re-vascularise and mimic the mechanical properties of native tissue. The major objective of this
Externí odkaz:
https://doaj.org/article/aa33168467d04b4ea36e8406a2544676
Development and clinical translation of tubular constructs for tracheal tissue engineering: a review
Autor:
Luis Soriano, Tehreem Khalid, Derek Whelan, Niall O'Huallachain, Karen C. Redmond, Fergal J. O'Brien, Cian O'Leary, Sally-Ann Cryan
Publikováno v:
European Respiratory Review, Vol 30, Iss 162 (2021)
Effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or congenital abnormalities remains an unmet clinical need in respiratory medicine. The trachea is a 10–11 cm long fibrocartilaginous tube of the lower resp
Externí odkaz:
https://doaj.org/article/97b08629d27c46eaa0083b7ae33eb3e2
Autor:
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Publikováno v:
Molecular Therapy - Nucleic Acids. 29:643-655
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1a9b223fb1e3a72b7919db16a8f10c
https://doi.org/10.1016/j.omtn.2022.08.004
https://doi.org/10.1016/j.omtn.2022.08.004
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 631 (2021)
Translation of novel inhalable therapies for respiratory diseases is hampered due to the lack of in vitro cell models that reflect the complexity of native tissue, resulting in many novel drugs and formulations failing to progress beyond preclinical
Externí odkaz:
https://doaj.org/article/7f872e35254148509db1c7f7a14d740e
Autor:
Sebastian Vencken, Camilla Foged, Joanne M. Ramsey, Louise Sweeney, Sally-Ann Cryan, Ronan J. MacLoughlin, Catherine M. Greene
Publikováno v:
ERJ Open Research, Vol 5, Iss 2 (2019)
Modulation of microRNAs (miRNAs), endogenous regulators of gene expression, is a promising strategy for tackling inflammatory lung diseases. In this proof-of-concept study, we tested delivery of miR-17 to bronchial epithelial cells (BECs) using nebul
Externí odkaz:
https://doaj.org/article/6e771108edc74bdaa53322887086e374
Publikováno v:
Current Research in Immunology. 3:54-72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37947d67c3bc6dee4b4b9ff48b11cae3
https://doi.org/10.1016/j.crimmu.2022.03.003
https://doi.org/10.1016/j.crimmu.2022.03.003