Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study

Autor: Damien K Ming, Saylee Jangam, Sally A N Gowers, Richard Wilson, David M E Freeman, Martyn G Boutelle, Anthony E G Cass, Danny O’Hare, Alison H Holmes

Publikováno v: BMJ Innovations. 8:87-94

IntroductionDetermination of blood lactate levels supports decision-making in a range of medical conditions. Invasive blood-sampling and laboratory access are often required, and measurements provide a static profile at each instance. We conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b72d36f76e0b5457787ff38e8b9138
https://doi.org/10.1136/bmjinnov-2021-000864

Complementary Metal-Oxide-Semiconductor Potentiometric Field-Effect Transistor Array Platform Using Sensor Learning for Multi-ion Imaging

Autor: Nicolas Moser, Yuanqi Hu, Chi Leng Leong, Martyn G. Boutelle, Pantelis Georgiou, Chiara Cicatiello, Sally A. N. Gowers

Publikováno v: Analytical Chemistry

This work describes an array of 1024 ion-sensitive field-effect transistors (ISFETs) using sensor-learning techniques to perform multi-ion imaging for concurrent detection of potassium, sodium, calcium, and hydrogen. Analyte-specific ionophore membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca24fb863772dc734beeecedaa026dc0
https://pubmed.ncbi.nlm.nih.gov/32142259

Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model

Autor: Georgia K Smith, Kirsten Møller, De-Shaine R. K. Murray, Martyn G. Boutelle, Sarah Jeyaprakash, Michelle L. Rogers, Markus Harboe Olsen, Isabelle C. Samper, Michael Karlsson, Sally A. N. Gowers

Publikováno v: Gowers, S A N, Samper, I C, Murray, D R K, Smith, G K, Jeyaprakash, S, Rogers, M L, Karlsson, M, Olsen, M H, Møller, K & Boutelle, M G 2020, ' Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model ', The Analyst, vol. 145, no. 5, pp. 1894-1902 . https://doi.org/10.1039/C9AN01950B

This work describes a fully-integrated portable microfluidic analysis system for real-time monitoring of dynamic changes in glucose and lactate occurring in the brain as a result of cardiac arrest and resuscitation. Brain metabolites are sampled usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b7f2c287a09a3d8d8f7171433668d1
http://hdl.handle.net/10044/1/76226

3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate

Autor: Isabelle C, Samper, Sally A N, Gowers, Michelle L, Rogers, De-Shaine R K, Murray, Sharon L, Jewell, Clemens, Pahl, Anthony J, Strong, Martyn G, Boutelle

Publikováno v: Lab on a chip. 19(11)

This paper presents the design, optimisation and fabrication of a mechanically robust 3D printed microfluidic device for the high time resolution online analysis of biomarkers in a microdialysate stream at microlitre per minute flow rates. The device

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::589002cb2bda0f79b183ea6af4a03f6f
https://pubmed.ncbi.nlm.nih.gov/31094398

3D Printed Microfluidic Device with Integrated Biosensors for Online Analysis of Subcutaneous Human Microdialysate

Autor: Guang-Zhong Yang, Vincenzo F. Curto, Pankaj Vadgama, Martyn G. Boutelle, Carlo A. Seneci, Salzitsa Anastasova, Chu Wang, Sally A. N. Gowers

Publikováno v: Analytical Chemistry

This work presents the design, fabrication, and characterization of a robust 3D printed microfluidic analysis system that integrates with FDA-approved clinical microdialysis probes for continuous monitoring of human tissue metabolite levels. The micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9093231da2a270f54d5217bf7a61a403
https://doi.org/10.1021/acs.analchem.5b01353